Clinical trials: Ventricular Dysfunction
Heart Diseases, Left Ventricular Dysfunction
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction
To test the specific research questions, healthy men and age-matched healthy premenopausal females will be enrolled. Subjects will undergo cardiac magnetic resonance imaging and spectroscopy (MRI/MRS) to evaluate cardiac…
- Trial name
- NCT04671966
- Testing
- Estradiol patch, Cetrotide, Fasting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Pulmonary Disease, Chronic Obstructive
Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
The aim of this study is to identify whether actively induced dynamic hyperinflation can cause left-ventricular diastolic dysfunction in healthy male subjects in order to explore the mechanisms of developing cardiac dysfunctions…
- Trial name
- NCT03500822
- Testing
- Metronome-paced tachypnea, Expiratory-stenosis breathing
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Otto Wagner Hospital
Aortic Stenosis
Microvascular Dysfunction in Aortic Stenosis
Aortic stenosis (AS), or narrowing of the aortic valve, is the commonest condition requiring valve surgery in the developed world. It is currently not known what determines who will go on to develop symptoms.
- Trial name
- PRIMID-AS (NCT01658345)
- Where
- 3 sites in United Kingdom
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Tako-tsubo Cardiomyopathy
Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation?
Tako Tsubo Cardiomyopathy (TTC), also known as "Broken Heart Syndrome", is a disorder of the heart that occurs most commonly in women (although it occasionally occurs in men) and is usually related to a stressful event.
- Trial name
- TERRIFIC (NCT02897739)
- Testing
- Magnetic resonance imaging, Acute Inflammatory Activation study, PET CT
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
RV - Right Ventricular Abnormality, LV Dysfunction
Pediatric Ventricle Function Assessment Study
This study aims to develop a deep learning-based framework for right ventricular (RV) segmentation, prediction of RV fractional area change (FAC), and identification of pediatric RV dysfunction.
- Conditions
- RV - Right Ventricular Abnormality, LV Dysfunction, Pulmonary Hypertension, TOF
- Trial name
- NCT06739057
- Where
- United States
- Volunteers
- 3,993 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Sleep Apnea, Obstructive
Right Ventricular Function in Obstructive Sleep Apnea
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic and pulmonary arterial hypertension and their correlation to the severity of…
- Trial name
- NCT00640536
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
Exercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear.
- Trial name
- NCT06715748
- Testing
- Ketone Monoester (KE)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronary Endothelial Dysfunction, Apical Ballooning Syndrome
The Relationship Between the Response to Mental Stress and Vascular Endothelial Function
The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects.
- Conditions
- Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction
- Trial name
- NCT00975559
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Left Ventricular Dysfunction
Strategic Management to Improve CRT Using Multi-Site Pacing Post Approval Study (Reference # C1918)
Prospective, multi-center, single arm, post approval study to be conducted in the United States.
- Trial name
- SMARTMSP (NCT03257436)
- Testing
- CRT-D
- Where
- 54 sites in United States
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Left Ventricular (LV) Systolic Dysfunction
AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation Study
This multicenter retrospective study evaluates whether artificial intelligence-enabled electrocardiography (AI-ECG) can identify individuals at high risk for left ventricular dysfunction and whether targeted guideline-directed…
- Trial name
- NCT07355023
- Testing
- Guideline-directed medical therapies
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Left Ventricular Diastolic Dysfunction, Weaning Failure
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality.
- Conditions
- Left Ventricular Diastolic Dysfunction, Weaning Failure, Mechanical Ventilation Complication, Diaphragmatic Disorder
- Trial name
- NCT04703387
- Testing
- transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve
Biomarkers in Aortic Stenosis - B.A.S.S.
This study is being done to determine whether or not new blood test(s) can determine the severity of heart conditions. Aortic stenosis, hypertrophic cardiomyopathy, mitral regurgitation, aortic regurgitation, artificial heart…
- Conditions
- Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- BASS (NCT01334801)
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sodium Excess
Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who…
- Trial name
- NCT04233957
- Testing
- High Sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Heart Diseases, Left Ventricular Dysfunction
InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's
The primary reason the investigators are doing this study are to understand how the right side of the heart functions in heart failure patients with left ventricular assist devices (LVADs, or "mechanical hearts").
- Trial name
- ROBIN (NCT03232736)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Takotsubo Cardiomyopathy
Sympathetic and Vascular Function in Takotsubo Syndrome
The primary objective of this prospective, observational study is to compare muscle sympathetic nerve activity at rest and during stress between female patients with Takotsubo syndrome and healthy, matched volunteers.
- Trial name
- SAFT (NCT05768542)
- Testing
- Metoprolol Injection, Saline
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital