Clinical trials: Vitamin B1 Deficiency
Thiamine Deficiency
Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders
Thiamine deficiency, including the most severe form infantile beriberi, is a public health concern across South and Southeast Asia, where monotonous diets rely on thiamine-poor white rice.
- Trial name
- NCT05390086
- Testing
- Standard of care
- Where
- 2 sites in Laos
- Volunteers
- 42 people
- Sponsor
- University of California, Davis
Lactate Blood Increase, Thiamine Deficiency
The Thiamine Administration After Cardiac Surgery Trial
Thiamine (Vitamin B1) is essential for cell function and as a co-factor of the enzyme Pyruvate Dehydrogenase to initiate the Krebs cycle and thus the aerobic metabolism of glucose.
- Trial name
- TAACS (NCT04641104)
- Testing
- Thiamine 500 MG
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Sarah Saxena
Dry Beriberi
Study of Dry Beriberi in Mayotte, Comoro Archipelago
The purpose of this study is to assess the existence of a genetic factor, suspected to be involved, aside from likely food deficiency contribution, in occurrence of dry beriberi, in patients who experienced dry beriberi and in a…
- Trial name
- MABECO (NCT00934349)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Sud Reunion
Heart Failure
A Trial of Thiamin Supplementation in Patients With Heart Failure
Background: Patients with heart failure (HF) are at increased risk of developing thiamin deficiency (TD). Thiamin (vitamin B1) is required for the production of energy and therefore TD may contribute to the energy depletion…
- Trial name
- NCT00959075
- Testing
- Vitamin B1
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Thiamine Deficiency
Trial of Thiamine Supplementation in Cambodia
Beriberi is a potentially fatal disease caused by vitamin B1 (thiamine) deficiency that still occurs in Southeast Asia despite near eradication elsewhere.
- Trial name
- NCT03616288
- Testing
- thiamine (as thiamine hydrochloride)
- Where
- Cambodia
- Volunteers
- 335 people
- Sponsor
- Mount Saint Vincent University
Beriberi
Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants
Thiamine deficiency causes beriberi and is common in parts of rural Cambodia, where it appears to be a leading cause of infant death.
- Trial name
- NCT01864057
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States, Cambodia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Thiamine and Niacin Deficiency States
Natural Versus Synthetic Vitamin B Complexes in Human
In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) (Pan [Greek] = all; moles [Latin] = molecules/particles - brand name) versus synthetic vitamin B complexes to identify the bioavailability…
- Conditions
- Healthy, Thiamine and Niacin Deficiency States, Pyridoxine Deficiency, Folic Acid Deficiency Anemia, Dietary
- Trial name
- NCT03444155
- Testing
- Natural Panmol-B-Complex, Synthetic Vitamin B-Complex
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Thiamine Deficiency, Congenital Heart Disease
Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass
This is a randomized, double-blind, controlled trial design. It was conducted with a main purpose of evaluating the effect of thiamine supplementation on serum lactate and lactate-pyruvate ratio after surgery as direct indicators…
- Conditions
- Thiamine Deficiency, Congenital Heart Disease, Cardiopulmonary Bypass
- Trial name
- NCT04453761
- Testing
- Neurobion
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Hematopoietic Stem Cell Transplantation, Delirium
High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation
Purpose: To conduct a randomized controlled pilot study investigating the use of high dose intravenous (IV) thiamine to prevent delirium and mitigate the long-term effects of delirium, including health-related quality of life…
- Conditions
- Hematopoietic Stem Cell Transplantation, Delirium, Thiamine Deficiency
- Trial name
- NCT03263442
- Testing
- Thiamine, Normal saline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Sepsis, Thiamine Deficiency
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)
This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels…
- Trial name
- NCT05663164
- Testing
- Vitamin B
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Sumatera Utara
Heart Diseases
Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs
The purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.
- Trial name
- NCT03989700
- Testing
- Thiamine Mononitrate
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Congenital Heart Disease, Thiamine Deficiency
The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease
Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of…
- Conditions
- Congenital Heart Disease, Thiamine Deficiency, Patent Ductus Arteriosus, Ventricular Septal Defect
- Trial name
- NCT06298344
- Testing
- Thiamine
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Sumatera Utara
Septic Shock, Shock, Septic
Thiamine Supplementation in Patients With Septic Shock
To determine if intravenous thiamine would decrease the time to reversal of shock in patients with septic shock.
- Conditions
- Septic Shock, Shock, Septic, Lactic Acidosis, Thiamine Deficiency
- Trial name
- NCT03122678
- Testing
- Thiamine
- Where
- United States
- Sponsor
- The Cleveland Clinic
Vitamin B1 Deficiency, Thiamine Deficiency
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
In Part 1, subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim. Part 2 will expand on Part 1 and subjects will be administered thiamine and thiamine with trimethoprim.
- Trial name
- NCT03746106
- Testing
- Trimethoprim, Metformin, Vitamin B1
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sepsis, Kidney Injury
Thiamine as a Renal Protective Agent in Septic Shock
This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous thiamine (vitamin B1) on renal function in septic shock.
- Conditions
- Sepsis, Kidney Injury, Thiamine Deficiency
- Trial name
- NCT03550794
- Testing
- Thiamine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Beth Israel Deaconess Medical Center
Inflammation, Magnesium Deficiency
Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)
We wish to determine to what extent magnesium, thiamine and transketolase activity are affected by the Systemic Inflammatory Response (SIR).
- Conditions
- Inflammation, Magnesium Deficiency, Iron-deficiency, Thiamine Deficiency
- Trial name
- SirTaM (NCT03554668)
- Testing
- Blood draw
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Glasgow Royal Infirmary
Diabetic Patient Before and After Bariatric Surgery, Nutrition Deficiency(VitB1 VitB12.Ca.Fe)
Prevalence of Major Nutrients Deficiency in Diabetic Patient Before and After Bariatric Surgery
The increasing demand of bariatric surgery requires ongoing improvement of the preoperative and post-operative care of morbidly obese patients.
- Trial name
- NCT03244839
- Testing
- bariatric surgery
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Min-Sheng General Hospital
Obesity, Child
Thiamin Deficiency in Obese Thai Children
This study is aimed to assess the prevalence of thiamin deficiency in obese Thai children.
- Conditions
- Obesity, Child, Thiamine Deficiency
- Trial name
- NCT02464865
- Testing
- Thiamine 1, Non-thiamine, Thiamine 2
- Where
- Thailand
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cardiac Arrest, Shock
Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest.
- Conditions
- Cardiac Arrest, Shock, Lactic Acidosis, Thiamin Deficiency
- Trial name
- NCT02974257
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Beth Israel Deaconess Medical Center