Clinical trials: WOUNDS INJURIES
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Osteoporosis, Fracture
Bone Microarchitecture in Women With and Without Fracture
Osteoporosis is a common disorder of compromised bone strength causing 40-50% of women and ~25% of men to sustain fragility fractures during their lifetime.
- Trial name
- mMRI (NCT01049191)
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy
Circulating Tumor Cell Genome in Peripheral Blood From Hepatocellular Carcinoma Patients Under Radiotherapy
Hepatocellular carcinoma (HCC) is a common cause of cancer mortality in Asia. Most patients were presented with advanced disease.
- Conditions
- Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy, Fatal Outcome
- Trial name
- NCT02066974
- Testing
- hepatoma requiring radiotherapy
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- China Medical University, China
Tear; Knee, Cartilage, Articular
Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures
This is a phase III, randomised controlled trial of matrix-encapsulated chondrocyte implantation procedure compared to the microfracture procedure in the repair of symptomatic cartilage lesions of the knee.
- Trial name
- NCT01947374
- Testing
- Matrix encapsulated chondrocyte implantation, Microfracture awl
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Carpal Tunnel Syndrome
Efficacy of Ultrasound-guided Transverse Carpal Ligament Release for Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is one of the most common peripheral nerve entrapment neuropathies, and it is characterized by pain, numbness, tingling, and weakness in the regions innervated by the median nerve (MN).
- Trial name
- NCT06251674
- Testing
- long-axis needle release, short-axis needle release
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Shoulder Impingement Syndrome.
Evaluation of the Difference in the Acromion Humerus Gap at Sitting,Lying
The Objective is to evaluation the difference between the upper end of the Humerus head and the bottom end of the Acromion in sitting and lying, and to examine this difference to shoulder pain.
- Trial name
- NCT01264926
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Burns
Effect of rFVIIa on Peri-operative Blood Loss in Patients Undergoing Major Burn
The purpose of the study is to see if a medication (Recombinant Coagulation Factor VIIa or NovoSeven), normally used to stop bleeding in persons with a bleeding disorder, will lower the amount of blood lost during burn surgery.
- Trial name
- NCT00243243
- Testing
- Recombinant Factor VIIa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
Rupture of Hip Abductor Tendon (Disorder)
Hip Abductor Tendon Repair Versus Sham Surgery
This study will examine the effectiveness of open surgical reconstruction in the treatment of patients with hip abductor tendon tears.
- Trial name
- NCT06398015
- Testing
- Surgical reconstruction of hip abductor tendon tear
- Where
- Denmark
- Sponsor
- Horsens Hospital
Intestinal Perforation, Intestinal Obstruction
Direct Peritoneal Resuscitation for Intra-abdominal Catastrophes
It is a retrospective study. Patients, who presented with either traumatic or general surgery emergencies, undergone exploratory laparotomy, had an open abdomen management and received Direct Peritoneal Resuscitation in addition…
- Conditions
- Intestinal Perforation, Intestinal Obstruction, Trauma Abdomen
- Trial name
- NCT05208489
- Testing
- there is no intervention involved in this study
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- New York Medical College
Ankle Fractures, Splints
Post Operative Ankle Splint Study - Prospective Multi Center Randomized Controlled Trial
Background: Ankle fractures are some of the most common orthopedic presentations, however, controversy in their management and their post-operative rehabilitation protocols exist.
- Trial name
- PASS (NCT04796168)
- Testing
- Splinting (plaster of paris)
- Where
- Kuwait
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuwait Institute for Medical Specialization
Dysplasia; Hip
Spica Cast Duration for DDH
This study looks at treatment for developmental dysplasia of the hip (DDH), a condition where there is abnormal development of a child's hip joint.
- Trial name
- NCT06204068
- Testing
- Spica cast, Rhino brace
- Where
- United States
- Sponsor
- Yale University
Resilience and Mental Health of First Responders
First Responder Safety Training (FiRST)
As a result of chronic exposures to traumatic and stressful events, first responders are at elevated risk for experiencing post-traumatic stress disorder (PTSD) and other mental health problems.
- Trial name
- FiRST (NCT07478250)
- Testing
- Worker Resilience Training Program, Fire and Medical Safety (FAMS)
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- Stony Brook University
Chronic Ankle Instability, Ankle Sprains
A Study Investigating The Effects Of An Ankle Rehabilitation Program On High School Athletes With Ankle Instability
A randomized controlled trial investigating the effects of a 4-week ankle rehabilitation program on high school athletes with chronic ankle instability.
- Conditions
- Chronic Ankle Instability, Ankle Sprains, Ankle Rehabilitation
- Trial name
- NCT03447652
- Testing
- Resistance Band Ankle Rehabilitation, Biomechanical Ankle Platform System Rehabilitation, Combination Rehabilitation
- Where
- 7 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Patellar Dislocation, ACL Injury
The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) .
- Conditions
- Patellar Dislocation, ACL Injury, Meniscus Lesion, Trochlear Dysplasia
- Trial name
- FKC (NCT04607538)
- Testing
- No intervention is made
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Mild Traumatic Brain Injury
New Protein Biomarkers and Technology for Improving Diagnosis and Outcome Prediction in Mild TBI
Mild traumatic brain injury(mTBI) is a common cause of consultation to the emergency rooms worldwide and is the most common form of traumatic brain injury.
- Trial name
- NCT06327776
- Testing
- Serum and saliva biomarkers
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitario 12 de Octubre
Lateral Epicondylitis
Comparative Effectiveness of Ultrasound-Guided Tenoxicam and Corticosteroid Injections for Lateral Epicondylitis
This prospective, randomized, comparative clinical study aims to compare the effectiveness of ultrasound-guided corticosteroid and tenoxicam injections in patients with lateral epicondylitis.
- Trial name
- NCT07883876
- Testing
- methylprednisolone acetate, tenoxicam
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara Etlik City Hospital
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Lung Disease Airways, Lung Diseases, Obstructive
TruFreeze™ Airway Obstruction: TAO STUDY
The purpose of this study is to prospectively assess the efficacy and safety of spray cryotherapy ablation with the truFreeze System in conjunction with mechanical dilation or debridement for the treatment of clinically…
- Conditions
- Lung Disease Airways, Lung Diseases, Obstructive, Airway; Obstruction, With Emphysema, Airway Obstruction
- Trial name
- TAO (NCT01903850)
- Testing
- spray cryotherapy
- Sponsor
- CSA Medical, Inc.
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Back Pain, Spinal Stenosis
Perioperative ACT for Preventing CPSP
The present study aims to adapt and modify a brief perioperative Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use.
- Conditions
- Back Pain, Spinal Stenosis, Spondylosis, Spondylolisthesis
- Trial name
- PREPS (NCT06750874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Samantha Meints
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