Clinical trials: Water-Borne Infectious Disease
Diarrhea, Gastrointestinal Infection
Wells and Enteric Disease Transmission
Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from…
- Conditions
- Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
- Trial name
- WET (NCT04826991)
- Testing
- Active UV Device, Inactive UV Device
- Where
- United States
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Temple University
Arsenic Poisoning, Environmental Exposure
Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire
The goals of this clinical trial are to: 1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L)…
- Conditions
- Arsenic Poisoning, Environmental Exposure, Water-Related Diseases
- Trial name
- NCT07103356
- Testing
- Water Pitcher Filtration System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
HIV/AIDS, HIV Prevention
Evaluating Distribution of a Tenofovir Douche With Tap Water Douching and Simulated Receptive Anal Intercourse
DREAM-02 is a phase 1, open label study to evaluate different sequences of tap water douching and simulated receptive anal intercourse (sRAI) in the presence of a tenofovir douche designed to confer protection from Human…
- Trial name
- DREAM-02 (NCT04195776)
- Testing
- Tenofovir Douche
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infection
Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection
The objective of the present study is to analyze the overall tubular function, and in particular that from the proximal tubule and the thick ascending loop of Henle (TALH) in patients with HIV infection receiving or not…
- Trial name
- NCT01869010
- Testing
- Low sodium water overload in HIV tenofovir, HIV no tenofovir and seronegative controls
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Water-Related Diseases, Enteric Pathogens
Rural Appalachia Pilot Water Treatment Trial
Consumption of unsafe drinking water is associated with a substantial burden of disease globally. In the USA, the burden of disease associated with consumption of contaminated drinking water from non-regulated private wells and…
- Conditions
- Water-Related Diseases, Enteric Pathogens, Exposure to Chemical Pollution
- Trial name
- NCT06120985
- Testing
- Countertop pitcher water filter
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Water Quality, Water Consumption
Preventing Hemolysis and Reducing Reverse Osmosis Waste With Instantaneous Measurement of Water Quality and Early Warning System in Hemodialysis: A New Method, "Pure Water Eye"
This study validates a novel, continuous, and instantaneous water quality monitoring method, the "Pure Water Eye," for hemodialysis (HD) systems.
- Conditions
- Water Quality, Water Consumption, Water-Related Diseases, Hemodialysis Complication
- Trial name
- HEMOWAQNEWS (NCT07247539)
- Testing
- Pure Water Eye Continuous Monitoring System
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Usak State Hospital
Cytomegalovirus Infections, HIV Infections
Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study
To determine whether acute ionized hypomagnesemia and hypocalcemia immediately following foscarnet infusions can be lessened or eliminated by prior infusion of magnesium sulfate.
- Conditions
- Cytomegalovirus Infections, HIV Infections, Hypocalcemia
- Trial name
- NCT00002146
- Testing
- Magnesium sulfate, Foscarnet sodium
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Astra USA
Diarrhea, Waterborne Disease
Trial of Safe Water Storage Among People Living With HIV
Environmental health-related pathogens include faecal-oral, diarrhoeagenic microbes that may be transmitted via drinking water and are related to sanitation and hygiene.
- Conditions
- Diarrhea, Waterborne Disease, HIV
- Trial name
- NCT01376336
- Testing
- Safe storage device
- Where
- Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cryptosporidium; Diarrhea, Cryptosporidiosis
Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya
The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya.
- Conditions
- Cryptosporidium; Diarrhea, Cryptosporidiosis, Communicable Diseases, Diarrheal Disease
- Trial name
- NCT01695304
- Testing
- Ceramic water filter
- Where
- Kenya
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Environmental Health, Adolescent Health
Evaluating the Effectiveness of Print Based Environmental Health Intervention Education Among School Going Adolescents of Karachi, A Quasi Study
This study investigates the impact of school-based educational interventions on adolescents' knowledge and practices related to environmental health in Karachi, Pakistan.
- Conditions
- Environmental Health, Adolescent Health, Green Spaces, Plantation
- Trial name
- NCT07379983
- Testing
- Educational Intervention either from Poster or Infographic pamphlet
- Where
- Pakistan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bahria University
Infection, Human Immunodeficiency Virus
Bioavailability Study of a Dolutegravir Dispersible Tablet and Effect of Different Types of Water on the Dispersible Tablet in Healthy Volunteers
Dolutegravir (DTG) is an HIV-1 integrase inhibitor approved in the United States, Canada, Australia and EU. A dispersible tablet has been developed for pediatric use as an alternative to the granule formulation, already in…
- Trial name
- NCT02185300
- Testing
- Dolutegravir Pediatric Granules, Dolutegravir Dispersible Tablet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Mexico
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- NCT04736615
- Testing
- SAFEWATER systems for drinking water disinfection, Behavior change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Waterborne Diseases, Diarrhea
Water Filter Study in Ciudad Victoria
This study measures effects of water filters and filter types on household health in Ciudad Victoria, Mexico.
- Trial name
- NCT06149715
- Testing
- Bottle Filter, Bucket Filter, Tap Filter
- Where
- Mexico
- Volunteers
- 9,887 people, healthy volunteers welcome
- Sponsor
- Aquora Research & Consulting, LLC
Cholera, Water-Related Diseases
Preventative Intervention for Cholera for 7 Days
The first objective of our study is to develop a theory-driven evidence-based targeted water, sanitation, and hygiene (WASH) intervention for household members of diarrhea patients in South Kivu, Democratic Republic of the Congo…
- Conditions
- Cholera, Water-Related Diseases, Diarrhea Infectious
- Trial name
- PICHA-7 (NCT05166850)
- Testing
- PICHA7 mHealth program, Standard Arm
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 2,900 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Death, Death, Infant
Coupons for Safe Water Project
Guaranteeing access to safe drinking water is still a challenge in rural households in developing countries, and unsafe water sources are responsible for millions of deaths each year around the world.
- Conditions
- Death, Death, Infant, Diarrhea, Diarrhea, Infantile
- Trial name
- Coupons (NCT05766826)
- Testing
- Coupons for safe water program: Treatment, Coupons for safe water program: Control
- Where
- 2 sites in Kenya
- Volunteers
- 3,468 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Colombia
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- SAFEWATER (NCT04829981)
- Testing
- SAFEWATER systems for drinking water disinfection, Behaviour change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Tropical Disease
A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru
Tropical diseases are continuously on the rise throughout the world as they are spreading and manifesting in various locations globally.
- Trial name
- NCT03078894
- Testing
- Zika, Chikagunya, Dengue
- Where
- 4 sites in Peru
- Volunteers
- 100 people
- Sponsor
- BioRed LLC
Parkinson's Disease, HIV Infections
Using Heavy Water to Study Cell Dynamics in Parkinson's Disease
This pilot study will assess the feasibility of using heavy water as a safe 'tracer' for biomarker studies of diseases of the brain and spinal cord, that, together, are also called the central nervous system (CNS).
- Trial name
- NCT00990379
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Salena Killion
Nutrition Poor, Aflatoxins Toxicity
One Nutrition in Complex Environments (ONCE)
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk…
- Conditions
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- Trial name
- ONCE (NCT04209569)
- Testing
- Nutrition Impact and Positive Practice Circle (NIPP)
- Where
- Uganda
- Volunteers
- 1,834 people, healthy volunteers welcome
- Sponsor
- Tufts University
HIV Infections, Human Immunodeficiency Virus
Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya
In many areas of the world most severely affected by the HIV/AIDS pandemic, insect and water-borne diseases such as malaria and diarrheal disease are common causes of illness and death.
- Conditions
- HIV Infections, Human Immunodeficiency Virus, Malaria, Plasmodium Falciparum
- Trial name
- ITN (NCT00914225)
- Testing
- Bednets and Water Purification
- Where
- 2 sites in Kenya
- Volunteers
- 500 people
- Sponsor
- University of Washington