Clinical trials: Weaning Invasive Mechanical Ventilation
Respiratory Failure
Respiratory Physiotherapy in Mechanical Ventilation
This study aimed to evaluate the effect of respiratory physiotherapy that is breathing exercise during weaning on ventilated patients in ICU.
- Trial name
- NCT04670939
- Testing
- breath exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Muğla Sıtkı Koçman University
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin
Pneumonia, Invasive Mechanical Ventilation
Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients
Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning).
- Conditions
- Pneumonia, Invasive Mechanical Ventilation, Weaning From Mechanical Ventilation in Care Unit, Respiratory Muscle Dysfunction
- Trial name
- NCT07405567
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Respiratory Insufficiency
B-type Natriuretic Peptide for the Management of Weaning
Several clinical findings and clinical trials have suggested that the prognosis of intensive care unit (ICU) patients may be improved by minimizing the positive fluid balance.
- Trial name
- BMW (NCT00473148)
- Testing
- BNP-guided weaning, Standard physician-directed weaning
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
Patients Requiring Endotracheal Intubation and Invasive Mechanical Ventilation
Weaning Outcome From Invasive Mechanical Ventilation
The main purpose of the present study was to explore the weaning failure rate from invasive mechanical ventilation and to identify risk factors of weaning failure.
- Trial name
- NCT02981589
- Testing
- Invasive mechanical ventilation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Cardiometry, Thorathic Fluid Content
The Validity of Thorathic Fluid Content as Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients
Introduction Weaning from mechanical ventilation (MV) could be described as the process of removing ventilator support. Weaning from MV often implies two separate but closely linked views of care, elimination of MV of any…
- Conditions
- Cardiometry, Thorathic Fluid Content, Weaning From Mechanical Ventilation
- Trial name
- NCT06685406
- Testing
- Thorathic fluid content measurement by cardiometry
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Chronic Obstructive Pulmonary Disease
CLEAR Model for Predicting Ventilatory Liberation in Severe COPD
This prospective observational cohort study aims to prospectively evaluate and validate the Clinical Load, Exchange, Ability of Respiration, and Reserve (CLEAR) model for predicting sustained ventilatory liberation in patients…
- Trial name
- CLEAR (NCT07579052)
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Relationship Between Dyspnea and Ventilatory Variability
Respiratory Variability and Dyspnea During Spontaneous Breathing Trial
In intensive care unit, dyspnea, the distressing and fearful awareness of breathing, is frequent and harmful. To be treated, dyspnea must be detected and quantified, which is impossible in approximately 50% of patients receiving…
- Trial name
- DYSREVA (NCT05762614)
- Testing
- Dyspnea assessment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Weaning Invasive Mechanical Ventilation
Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients
Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing.
- Trial name
- NCT07455214
- Testing
- BEATINFO ECG Sensor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Ventilator Weaning
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation
A UK multi-centre cluster randomised controlled trial to determine if a protocol-based intervention incorporating coordinated care with greater nursing involvement to managing sedation and ventilator weaning can reduce the…
- Trial name
- SANDWICH (NCT03673683)
- Testing
- SANDWICH protocol, Usual care
- Where
- 17 sites in United Kingdom
- Volunteers
- 10,498 people
- Sponsor
- Queen's University, Belfast
Respiratory Insufficiency
Evaluation of the Therapeutic Usability of RESPIRA ADVANCED Device in Patients Under Invasive Mechanical Ventilation
The objective of the clinical investigation presented is to guarantee the safety and usability of the RESPIRA ADVANCED medical device in patients undergoing mechanical ventilation in the ICU, both stable patients and in the…
- Trial name
- RESPIRA-02 (NCT05174130)
- Testing
- RESPIRA device.com® Advanced
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
COPD (Chronic Obstructive Pulmonary Disease), Cardiometry
Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Cardiometry, Weaning Invasive Mechanical Ventilation
- Trial name
- NCT07109206
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Assiut University
Intensive Care Unit, Invasive Mechanical Ventilation
Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation
Assessment and comparison of three spontaneous breathing trials in five specific profiles of intensive care unit and perioperative patients. A physiological cross over study
- Conditions
- Intensive Care Unit, Invasive Mechanical Ventilation, Ready to Wean From Ventilation
- Trial name
- GLOBAL WEAN (NCT04222569)
- Testing
- T-piece, PSV 7 and PEEP 0, PSV 0 and PEEP 0
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Failure Requiring Intubation
A Study on the Assessment of Difficult Weaning in Patients With Acute Respiratory Failure Undergoing Mechanical Ventilation Based on Machine Learning EIT-pendelluft: A Multicenter Retrospective Study.
Invasive mechanical ventilation (IMV) is a common method used in the ICU to assist breathing and promote gas exchange. When a patient's condition improves, the weaning process (WP) should be initiated.
- Trial name
- NCT06756204
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ruijin Hospital
Acute Respiratory Failure
Third International Study on Mechanical Ventilation
The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1.
- Trial name
- ISMV (NCT01093482)
- Where
- 477 sites in United States, Argentina and 36 more
- Volunteers
- 8,151 people
- Sponsor
- Hospital Universitario Getafe
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto