Clinical trials: Weight Changes, Body
Weight Gain, Antipsychotic Agents
Clozapine Induced Weight Gain
Clozapine is prescribed to patients with psychosis in whom other treatments have not worked. Research has shown, however, that clozapine may be associated with weight gain and abnormal blood sugar levels in some patients.
- Conditions
- Weight Gain, Antipsychotic Agents, Pharmacogenetics
- Trial name
- NCT03996356
- Testing
- No study intervention - observational study
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Overweight, Obesity
ACTION PAC: Adolescents Committed to Improvement of Nutrition & Physical Activity
Using a previously created weight management program for adolescents, the intervention will be implemented through school-based health centers (SBHC) and will be delivered by SBHC providers trained in Motivational Interviewing.
- Trial name
- ACTION PAC (NCT02502383)
- Testing
- ACTION PAC, Communication with parents
- Where
- United States
- Volunteers
- 991 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Malnutrition, Stunting
Child Health, Nutrition and Microbiome Development
Childhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children.
- Conditions
- Malnutrition, Stunting, Wasting, Underweight
- Trial name
- CHAMP (NCT05793294)
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Postoperative Complications
Sleeve Gastrectomy as a Standard Bariatric Procedure
This study compared differences in weight loss, comorbidity resolution and complications and reoperations between a recently established sleeve gastrectomy (SG) and prior laparoscopic Rox-en-Y gastric bypass (RYGB).
- Trial name
- NCT05336331
- Testing
- SG or a RYGB
- Where
- Sweden
- Volunteers
- 1,015 people
- Sponsor
- Umeå University
Eating Disorder, Anorexia
Adaptive Treatment for Adolescent Anorexia Nervosa
The investigators are conducting a randomized controlled trial using an adaptive design for adolescents (ages 12-18) with anorexia nervosa to compare standard Family Based Treatment (FBT) to adaptive FBT with an Intensive…
- Conditions
- Eating Disorder, Anorexia, Anorexia Nervosa, Anorexia in Adolescence
- Trial name
- NCT03097874
- Testing
- Family Based Treatment, Family Based Treatment + Intensive Parental Coaching
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Stanford University
Bariatric Surgery, Sleeve Gastrectomy
15-years Outcomes of Sleeve Gastrectomy on Weight Loss
Evaluate the beneficial and harmful effects of sleeve gastrectomy at 15 years in a pioneering center for this surgical technique in France
- Conditions
- Bariatric Surgery, Sleeve Gastrectomy, Weight Loss
- Trial name
- SLEEVE15 (NCT07883018)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Type 1 Diabetes
Efficacy of Pramlintide on Prevention of Weight Gain Early Onset of Type 1 Diabetes
In this pilot study we are evaluating the efficacy of pramlintide on preventing weight gain among early onset type 1 diabetes. We are also evaluating the safety and the effects of treatment with pramlintide on early diagnosed…
- Trial name
- NCT00505882
- Testing
- Pramlintide, Glargine, Lispro
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Endometrial Cancer, Mobile Applications
Application-Assisted Weight Management in Endometrial Cancer Fertility Preservation
This study is a single-center, prospective, randomized controlled trial targeting endometrial cancer (EC) patients undergoing fertility-sparing treatment at Peking University People's Hospital from March 2025 to March 2027.
- Conditions
- Endometrial Cancer, Mobile Applications, Weight Management
- Trial name
- NCT06901778
- Testing
- DEAR weight management, Standardized discharge care plan and follow-up schedule, Implementation of the weight management mobile health application
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Peking University People's Hospital
Obesity, Adolescent
Turnip Consumption and Qigong Exercise Program on Weight Loss
Obesity and weight-related issues are prevalent concerns affecting individuals worldwide, with particular significance among the younger demographic, such as female students.
- Trial name
- NCT06698835
- Testing
- Turnip Consumption
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Cachexia; Cancer
Impact of the Use of Nandrolone on the Treatment of Malnutrition Induced by Cancer
Compare the use of nandrolone associated with corticosteroid for the treatment of cancer-induced malnutrition to treatment with corticosteroids alone in patients with tumors in the high gastro-intestinal tract, liver, pancreas…
- Trial name
- NCT03263520
- Testing
- Nandrolone Decanoate, Dexamethasone
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Erasto Gaertner
Healthy
The Effect of Calorie Deprivation on Adipose Tissue Distribution
In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters.
- Trial name
- NCT01658397
- Testing
- Fasting
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cachexia, Non-Small Cell Lung Cancer
Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2)
The administration of Anamorelin in patients with Stage III-IV non-small cell lung cancer-cachexia (NSCLC-C) is expected to increase appetite, lean body mass, weight gain, and muscle strength.
- Trial name
- NCT01387282
- Testing
- Anamorelin HCl
- Where
- 46 sites in United States, Australia and 5 more
- Volunteers
- 495 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Childhood Obesity
"Mandometer®" Study for Managing Childhood Obesity
We run a successful clinic in Bristol for children with severe obesity who already demonstrate many features to suggest they are at increased risk of early diabetes and heart disease.
- Trial name
- NCT00407420
- Testing
- Mandometer, Lifestyle
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Bristol
Diabetes, Gestational, Gestational Weight Gain
Meals for Moms: Medically-Tailored Meals for Women Who Had Gestational Diabetes
The purpose of this research study is to test whether delivery of medically tailored meals (meals designed specifically to be healthy) can be used to help reduce high blood sugar after delivery of a baby.
- Conditions
- Diabetes, Gestational, Gestational Weight Gain, Postpartum Weight Retention
- Trial name
- NCT04866823
- Testing
- Medically Tailored Meals
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Tinnitus, Subjective
Lifestyle Changes in Obese Males With Sexual Dysfunction and Tinnitus
obese male usually complain subjective tinnitus that may affect their sexual function.
- Conditions
- Obesity, Tinnitus, Subjective, Erectile Dysfunction
- Trial name
- NCT06716125
- Testing
- aerobic treadmill walking plus low calorie diet, low calorie diet
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Hyperglycemia, Coronary Heart Disease
Paleolithic Diet in the Treatment of Glucose Intolerance
The purpose of this study is to determine whether a paleolithic diet improves glucose tolerance and insulin sensitivity in people with coronary heart disease and impaired glucose tolerance.
- Trial name
- NCT00419497
- Testing
- Paleolithic diet vs Mediterranean diet
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Obesity, Morbid, Time Restricted Eating
Time-restricted Eating Among Pregnant Females With Severe Obesity
In the United States, a body mass index (BMI) of at least 35.0 kg/m2 affects about 15% of women of reproductive age. Severe obesity is a significant predictor of adverse perinatal outcomes including gestational diabetes mellitus…
- Conditions
- Obesity, Morbid, Time Restricted Eating, Pregnancy Weight Gain
- Trial name
- TRE-Preg (NCT06477120)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Overweight and Obesity, Weight Loss
microRNA Testing for Identification of Personalized Weight Management
Certain blood markers are related to one's ability to successfully lose weight by diet and exercise. Currently, the laboratory tests used to measure these blood markers are expensive and time-consuming.
- Trial name
- NCT04217850
- Testing
- 250 kcal Dietary Energy Restriction, Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Obesity, Weight Loss
Efficacy of Oral Semaglutide in Overweight or Obesity
All the eligible participants after screening will be randomized into two groups (Group 1 and 2) by block randomization (block size of 4 and 6) using computer generated random number.
- Trial name
- OSO (NCT05442450)
- Testing
- oral semaglutide
- Where
- India
- Volunteers
- 116 people
- Sponsor
- Asian Institute of Gastroenterology, India
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