Clinical trials: White Spot Lesion
Tooth Demineralization
Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.
The purpose of this study is to learn more about the management of white spot lesions that occur after orthodontic treatment. White spot lesions generally improve slightly with time.
- Trial name
- NCT01059058
- Testing
- MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Washington
White Spot Lesion
Evaluation of Remin Pro Forte Versus Remin Pro on Treatment of White Spot Lesions Post Orthodontic Treatment
randomized clinical trial to evaluate caries regression, the change in colour and mineral content of the demineralized enamel after treatment with Remin Pro Forte paste (fluoride, hydroxyapatite, xylitol, ginger, and curcuma) and…
- Trial name
- NCT04017884
- Testing
- Remin Pro Forte, Remin Pro
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Development and Validation of a Multi-Mineral Fluoride Mouthrinse
The primary goals of this project are to determine the anticaries benefits of a prototype multi-mineral mouthrinse containing 225 ppm fluoride and 30 ppm of a Ca through the remineralization of enamel white-spots (non-cavitated…
- Trial name
- NCT00642252
- Testing
- Fluoride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana Nanotech, LLC
White Spot Lesion
Clinical Evaluation of White Spot Lesions Treated by S-PRG and ICON
Randomized with (1:1) prospective, double-blind, controlled trial. Subjects will be randomized to receive S-PRG and the control group receives ICON.
- Trial name
- NCT05550116
- Testing
- Giomer, Two composite resin sealants
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
White Spot Lesion
The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study
aim of study: is to compare the effect of the fluoride varnish application on the prevention of white spot lesions (WSLs) during clear aligner therapy Design Details: Each participant will have one side of the mouth assigned to…
- Trial name
- NCT07319884
- Testing
- White spot lesion with fluoride varnish application, White spot lesion without fluoride varnish application
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
White Spot Lesion
P11-4 and Nanosilver Fluoride Varnish in Treatment of White Spot Carious Lesions
Background: Great efforts have been undertaken for dental caries prevention. Among the recent remineralizing materials, Nano silver fluoride varnish products which are based on nanotechnology have been proposed for "repairing"…
- Trial name
- NCT04929509
- Testing
- self-assembling peptide, nanosilver fluoride varnish, sodium fluoride varnish
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
White Spot Lesion of Tooth
Effect of Bioactive Resin Material Containing S-PRG Filler on White Spot Lesions
the effect of bioactive resin composite containing S-PRG filler will be tested as the material of choice for attachments bonded on teeth prior to the use of orthodontic clear aligners compared to the conventionally used flowable…
- Trial name
- NCT07715942
- Testing
- Bioactive resin composite containing S-PRG filler, Conventional flowable composite is used for the attachments for the clear orthodontic aligners
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesion
The Effect of ICON Treatment on WPL With Patients After Fixed Orthodontic Appliances
The aim of this study is to determine the effect of ICON on White spot lesions compared to CPP-ACPF plus.
- Trial name
- NCT03391180
- Testing
- ICON Remineralization, CPP-ACPF
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
White Spot Lesions
The Effect of Nano Chitosan Surface Coating on White Spot Lesions Development in Clear Aligner Therapy Patients
In this study, it was intended to investigate the effect of nano Chitosan (antimicrobial agent) coating on clear aligner orthodontic appliance if it reduces the incidence of white spot lesions (demineralization) of enamel…
- Trial name
- NCT07715552
- Testing
- chitosan nanoparticles, No Treatment Added
- Where
- Jordan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesion, Orthodontic Appliance Complication
A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.
The goal of this randomized clinical trial is to compare the influence of casein phosphopeptide amorphous calcium phosphate (CPP-ACP), CPP-ACP in combination with fluoride (CPP-ACPF), high fluoride concentration, and conventional…
- Trial name
- NCT05710874
- Testing
- CPP-ACP paste, CPP-ACPF paste, 1.25% fluoride gel
- Where
- Belgium
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
White Spot Lesion of Tooth, Tooth Color
Toothpastes With Different Contents and Tooth Color
This study aims to investigate the color tone and fluorescence changes that may occur during fixed orthodontic treatment with brackets in patients' teeth using toothpaste with different properties.
- Conditions
- White Spot Lesion of Tooth, Tooth Color, Dentistry, Orthodontic Appliances, Fixed
- Trial name
- NCT06833970
- Testing
- Colgate use, Curaprox use, ROCS use
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taner OZTURK, DDS, MS
Demineralization, Tooth, Caries,Dental
Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment
Treatment with fixed orthodontic appliances is often associated with pain, which poses great challenges in the efficient brushing of the teeth thus making the teeth more vulnerable to plaque formation.
- Conditions
- Demineralization, Tooth, Caries,Dental, White Spot Lesion
- Trial name
- NCT04342858
- Testing
- Fluoride Varnish, Fluoride Varnish with tricalcium phosphate, Oral health education
- Where
- Hong Kong
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Gingival Hyperplasia, Dental Plaque
Clinical Efficacy of Chlorhexidine Varnish in Reducing Gingival Hyperplasia, Plaque Accumulation, and White Spot Lesions in Orthodontic Patients
This study investigates whether applying a chlorohexidine varnish (a dental coating) reduces gum overgrowth, plaque buildup, and early tooth decay (white spots) in patients with braces.
- Conditions
- Gingival Hyperplasia, Dental Plaque, Tooth Demineralization
- Trial name
- NCT07115784
- Testing
- Chlorhexidine Varnish
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
White Spot Lesion
Fluoride Controlled-release System for Initial Lesions of Caries
OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in a controlled-release system (F-CSL, patent pending) in the remineralization of white spot lesions of caries in caries-active…
- Trial name
- NCT05139966
- Testing
- Mouthwash Product
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
White Spot Lesion of Tooth
Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children
The aim of the present work is to study the effect of the application of Silver diamine fluoride (SDF) and a novel green synthesized Nano-silver fluoride (NSF) on early enamel lesions in primary teeth.
- Trial name
- NCT06489093
- Testing
- NSF, SDF+KI, Control group
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Remineralization
Clinical Efficacy of Different Remineralizing Agents in Treatment of White Spot Lesions
The aim of the present study is to evaluate the efficiency of Self-assembling Peptide P11-4, Tricalcium Phosphate Fluoride Varnish, 5% F- and 5% fluoride varnish in remineralization of WSLs in primary dentition among a group of…
- Trial name
- NCT05064137
- Testing
- Monomeric self - assembling peptide P11-4, Tricalcium phosphate fluoride varnish, 5% F-, fluoride varnish (5% sodium fluoride)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Dental Plaque
Orthodontic Varnish Microbiology Study
Orthodontic treatment is common in teenagers, which typically involve the attachment of metal brackets to the teeth. These brackets often impede proper oral hygiene, leading to plaque accumulation and the development of white…
- Conditions
- Dental Caries, Dental Plaque, Dental White Spot
- Trial name
- NCT04528134
- Testing
- Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Duodenal Diseases, White Spot Lesion
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases…
- Trial name
- NCT06200129
- Testing
- sws grade 1, sws grade 2, control
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
White Spot Lesion of Tooth
Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children
One hundred children with white spot lesions on their teeth were divivided into 5 groups of different remineralizing agents to assess their effect on color change and remineralization
- Trial name
- RCT (NCT06821724)
- Testing
- Casein phosphopeptide-amorphous calcium phosphate, Casein phosphopeptide-amorphous calcium phosphate + fluoride, Nano hydroxyapatite paste
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt