Clinical trials: Wrinkle, open to volunteers
Photoaged Facial Skin, Photoaging
Study of RRS® HA Long Lasting for Improving Facial Wrinkles and Skin Quality
The objective of this clinical study is to confirm the clinical performance and long-term safety of the CE-marked RRS® HA Long Lasting in the treatment of skin photoaging and its consequences, with a primary focus on improving…
- Conditions
- Photoaged Facial Skin, Photoaging, Wrinkle Reduction, Skin Quality Improvement
- Trial name
- ORACLE LL (NCT07551609)
- Testing
- RRS® HA Long Lasting
- Where
- 6 sites in Spain
- Volunteers
- 207 people
- Sponsor
- Skin Tech Pharma Group S.L.U.
Acne, Acne Scars - Mixed Atrophic and Hypertrophic
AVAVA MIRIA General Use
A general protocol to treat a variety of dermatologic conditions and collect patient feedback. Primary outcome is the collection and analysis of patient questionnaires related to the overall experience of the device treatment.
- Conditions
- Acne, Acne Scars - Mixed Atrophic and Hypertrophic, Scars, Wrinkle
- Trial name
- NCT06868615
- Testing
- AVAVA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AVAVA, Inc.
Photodamaged Skin, Rhytids
2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles
The primary objective is to assess the efficacy, safety and satisfaction associated with the resurfacing treatment of perioral lines and wrinkles with the 2,910 nm mid-infrared Fiber Laser (UltraClear, Acclaro Medical) using both…
- Conditions
- Photodamaged Skin, Rhytids, Lines Skin, Wrinkles and Rhytides
- Trial name
- NCT07222397
- Testing
- Laser Resurfacing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- FA Corporation
Nasolabial Fold Correction, Facial Aging
Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1
The goal of this clinical study is to learn whether the Bridging Technique can safely and effectively treat nasolabial folds (NLF, also known as smile lines) in adults.
- Conditions
- Nasolabial Fold Correction, Facial Aging, Skin Rejuvenation, Wrinkles Such as Nasolabial Folds
- Trial name
- BRIDGING (NCT07178119)
- Testing
- (Bridging) Horizontal Cannula Technique for Treatment of Nasolabial Folds using AILEENE Vol. 2
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. Joseph M Novoa Libermann
Perioral Wrinkles, Crow's Feet
Prospective, Non-interventional Study Assessing Perioral Rejuvenation Procedure
The goal of this observational study is to learn how a perioral rejuvenation procedure affects perioral line severity and lip volume over time in adults undergoing routine aesthetic treatment in a single clinical center.
- Conditions
- Perioral Wrinkles, Crow's Feet, Lip Volume Enhancement, Lip Aging
- Trial name
- NCT07398768
- Testing
- Saypha® Rich, Saypha® Filler Lidocaine
- Where
- Austria
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yuvell
Moderate to Severe Glabellar Lines
A Study to Assess the Effectiveness and Safety of IPN10200 in Adult Chinese Participants With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
The purpose of this study is to find out about the effectiveness and safety of a single dose of corabotase (also known as IPN10200) compared to placebo works in participants with moderate to severe glabellar lines.
- Trial name
- LAURITE 3 (NCT07779252)
- Testing
- Corabotase
- Where
- 9 sites in China
- Volunteers
- 160 people
- Sponsor
- Ipsen
Hair Loss/Baldness, Wrinkle Appearance
Autologous Adipose Cells Therapy
Autologous Adipose Cell Therapy is a series of process designated to address the demerits of the traditional autologous fat grafting and dermal fillers, while enhancing the versatility and aesthetic outcomes.
- Conditions
- Hair Loss/Baldness, Wrinkle Appearance, Volume, Fine Lines
- Trial name
- NCT06869252
- Testing
- Autologous Adipose Cells Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- CERM INC.
Crow's Feet
A Study on the Anti-Wrinkle Efficacy Assessment and Safety Evaluation of the Cluster of Autologous Dermal Fibroblast on Bilateral Crow's Feet
This study is a phase 1/2 clinical trial to evaluate the safety and efficacy of administering clusters of autologous dermal fibroblasts to subjects with periorbital wrinkles on both sides.
- Trial name
- NCT04818203
- Testing
- Clusters of Autologous Dermal Fibroblasts
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- S.Biomedics Co., Ltd.
Nasolabial Folds, Wrinkles
A Prospective Clinical Investigation of DMFI150 for Treating Nasolabial Folds
This is a prospective clinical investigation designed to evaluate the performance and safety of DMFI150 for the treatment of nasolabial folds. 30 adult participants will receive a single treatment with the investigational device.
- Trial name
- NCT07292779
- Testing
- DMFI150
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Samyang Biopharmaceuticals Corporation
Skin Rejuvenation, Laser
Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis…
- Trial name
- NCT07467954
- Testing
- Fractional CO₂ laser, Long-pulsed 1064-nm Nd:YAG laser
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Periorbital Wrinkles
Evaluation of the Safety and Performance of Epicare for the Treatment of Periorbital Wrinkles
This is a prospective, interventional, evaluator-blinded, multi-center clinical study designed to assess the safety and performance of the Epicare fractional nano-thulium (Tm:YAP 1938 nm) laser system for the treatment of…
- Trial name
- NCT07114562
- Testing
- Epicare
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laser team Ltd
Lips Enhancement, Perioral Wrinkles
Evaluation of Facial HA Dermal Fillers in Real-Life Conditions
The goal of this post-market interventional study is to confirm, under real-life conditions, the safety and performance of hyaluronic acid-based dermal fillers intended to modify skin anatomy and facial appearance.
- Conditions
- Lips Enhancement, Perioral Wrinkles, Nasolabial Fold Wrinkles, Cheek Augmentation
- Trial name
- NCT07255261
- Testing
- Facial injection of hyaluronic acid-based dermal fillers.
- Where
- 8 sites in France
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Symatese
Wrinkle, Glabellar Frown Lines
Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides
Study Type: This is a multicenter, triple-blind, randomized controlled trial. Purpose: The goal of this clinical trial is to compare the effectiveness and safety of all commercially available Botulinum Neurotoxin Type A (BoNT-A)…
- Conditions
- Wrinkle, Glabellar Frown Lines, Glabellar Furrowing
- Trial name
- NCT06448676
- Testing
- Botulinum toxin type A
- Where
- 3 sites in Netherlands
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Skin Aging, Skin Hydration
A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health
This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail…
- Conditions
- Skin Aging, Skin Hydration, Skin Elasticity, Fine Lines and Wrinkles
- Trial name
- NCT07746076
- Testing
- Naila's Collagen Marine Plus Food Supplement
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gulf Bird
Wrinkle Appearance, Skin Quality
A Study to Evaluate the Efficacy of Collagen 16 Serum Alone, Against and as an Adjunct to Radiesse® Biostimulation Procedure in Female Trial Participants With Aged Skin
This study aims at assessing the efficacy of improving skin aging signs of a serum containing collagen 16 combined with a biostimulation device in healthy female subjects aged between 30 and 70 years over a period of 13 weeks.
- Trial name
- NCT07446361
- Testing
- Group 1 (Biostimulation + Test product), Group 3 (Test product Alone)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Vichy Laboratoires
Facial Aging, Skin Laxity
Quantified Evaluation of Noninvasive System Delivering Microwave Energy for Unwanted Fat Reduction and Skin Tightening in Asians.
The goal of this observational study is to evaluate the effectiveness and safety of microwave-assisted heating technology in facial fat reduction and skin tightening in Asians. The main questions it aims to answer are: 1.
- Conditions
- Facial Aging, Skin Laxity, Cheek Wrinkles
- Trial name
- NCT06925074
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chang Chang Cheng
Skin Aging, Wrinkles in Decolletage
PIEZO-101 First-in-Human Safety and Proof-of-Concept Study
The aim of this first-in-human clinical study is to explore the safety, tolerability, pharmacodynamics, and exploratory efficacy of PIEZO-101, an investigational plasmid DNA biostimulator that aims to restore expression of key…
- Conditions
- Skin Aging, Wrinkles in Decolletage, Wrinkles in Left Knee, Left Knee Skin Laxity
- Trial name
- NCT07671027
- Testing
- PIEZO-101, Piezopen, Sterile Saline (0.9% NaCl)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Piezo Therapeutics, Inc.
Skin Aging, Dry Skin
Effects of Probiotics on Skin Health in Healthy Women
The effect of probiotics on skin health in healthy women with dry to very dry facial skin.
- Trial name
- NCT07887841
- Testing
- Probiotics
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Probi AB
Facail Skin Aging
Facial Exercise and Daily Habit Modification Program for Skin Quality and Wrinkle Severity in Middle-Aged Women
This randomized controlled trial will evaluate the effectiveness of a 12-week program combining facial muscle exercises and daily habit modification for improving skin quality and reducing wrinkle severity in middle-aged women.
- Trial name
- NCT07792460
- Testing
- Facial Exercise and Daily Habit Modification Program
- Where
- Iraq
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of Zakho
Aquagenic Wrinkling of Palms, Carrier State
Aquagenic Wrinkling Prediction
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.
- Trial name
- NCT06831110
- Testing
- Aquagenic Wrinkling
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Iowa