Clinical trials: asthma
Asthma
A Pilot Study to Improve Preventive Asthma Care for Urban Adolescents
The goal of this pilot study is to implement directly observed therapy with preventive asthma medications through a partnership with the school nurse (with input and direction from the primary care provider) to assure that the…
- Trial name
- NCT01106326
- Testing
- Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Asthma
AMP-BPT and His-BPT for Assessment of Asthma
Adenosine monophosphate (AMP) may reflect airway inflammation and hyperresponsiveness, but relationship between AMP and histamine (His, a conventional stimulus) bronchial provocation test (BPT) in asthma is not fully elucidated.
- Trial name
- AMPHis (NCT02318043)
- Testing
- inhaled corticosteroids (usually budesonide/fomorterol 160/4.5mcg; fluticasone/salmeterol 250/50mcg)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma, Vitamin D Deficiency
Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
The role of vitamin D in respiratory health remains uncertain. Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain.
- Trial name
- NCT01395589
- Testing
- Vitamin D
- Where
- Qatar
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Asthma
Effectiveness of Osteopathic Manipulative Treatment in Pediatric Asthma
Asthma is a highly prevalent chronic disease in children. Complementary and Alternative Medicine research on asthma showed a potential effect on pediatric patients.
- Trial name
- OMT (NCT01853189)
- Testing
- OMT + Usual Care, Usual Care
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Severe Persistent Asthma
A Pragmatic Trial of Corticosteroid Optimisation in Severe Asthma
This study explores if a composite biomarker strategy predicts exacerbation risk in patients with asthma on high dose inhaled corticosteroid (+/-long-acting beta agonist) treatment and to evaluate the utility of this composite…
- Trial name
- NCT02717689
- Testing
- Biomarker based adjustment of corticosteroid dose
- Where
- 11 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- Belfast Health and Social Care Trust
Asthma
Study on Foster Efficacy Maintenance and Reliever vs Foster Maintenance + Salbutamol Reliever in Asthmatics (MART2)
Primary objective: The primary objective of the study was to compare the efficacy of Maintenance and Reliever Therapy (MART) with Foster® 100/6 μg (one inhalation bid) plus additional inhalations as needed, with the standard…
- Trial name
- NCT00861926
- Testing
- Salbutamol, Beclomethasone dipropionate + Formoterol
- Where
- 206 sites in Bulgaria, Croatia and 12 more
- Volunteers
- 1,714 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Eosinophilic Asthma
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of…
- Trial name
- BRISOTE (NCT06750289)
- Testing
- ICS-LABA, benralizumab
- Where
- 86 sites in United States, Bulgaria and 11 more
- Volunteers
- 130 people
- Sponsor
- AstraZeneca
Asthma, Psychosocial Stress
Stress Management Intervention in Inner City Adolescents With Asthma
The study will utilize a stress management program delivered over 10 sessions that is hypothesized to result in decreased stress levels and improved coping strategies in an inner city adolescent asthma population.
- Trial name
- SIPIICAA (NCT01445015)
- Testing
- Stress management program, Peer viewed movies
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Exercise-induced Bronchospasm
Mechanisms of Exercise-induced Bronchospasm
The term exercise-induced bronchospasm (EIB) describes acute, transient airway narrowing that occurs during, and most often after, exercise.
- Trial name
- NCT00701025
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Severe Persistent Asthma
Bronchial Thermoplasty: Effect on Neuronal and Chemosensitive Component of the Bronchial Mucosa
In severe bronchial asthma the mechanism of inflammation and bronchospasm is complex and still not clarified. The smooth muscle cells play an important role from the mechanical point of view, as a culmination of neurogenic…
- Trial name
- BT-ASMN (NCT01839591)
- Testing
- catheter ALAIR
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Asthma
An ADME Study of [14C]AZD4604 and the Absolute Bioavailability of AZD4604
The Sponsor is developing the test medicine, AZD4604, as a potential treatment for asthma. Asthma is a common lung condition caused by inflammation (swelling) of the breathing tubes that carry air in and out of the lungs, causing…
- Trial name
- NCT06157255
- Testing
- AZD4604 Inhalation Powder, 1 mg, [14C]AZD4604 Solution for Infusion 6 μg/mL (NMT 37.0 kBq/5 mL), [14C]AZD4604 Oral Solution, 4 mg (NMT 37.0 kBq)
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma in Children
N-WATCH: Nottingham Wheeze Assessment in Tidal Children
Children with long-term lung diseases like asthma need better techniques for diagnosis and monitoring of their disease. With better monitoring, it is anticipated that children and their carers will be able to manage their disease…
- Trial name
- N-WATCH (NCT07833826)
- Testing
- N-Tidal
- Where
- 2 sites in United Kingdom
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Bronchial Asthma
A Clinical Study on the Prevention of Mild to Moderate Intermittent Asthma With Chinese Medicine Weiyang Yuping Fang
Clinical exploring study of Weiyang Yuping Decoction in preventing acute attacks of mild to moderate intermittent asthma Based on the theory of "Preventing disease from exacerbating" in Chinese medicine.
- Trial name
- NCT04522726
- Testing
- Weiyang Yuping Fang
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Eosinophils, Asthma
A Study of Reslizumab in Patients 12 Years of Age and Older With Severe Eosinophilic Asthma
This is a multicenter, open-label (OL) extension study to obtain additional long-term safety data for subcutaneous (sc) administration of reslizumab treatment administered at a fixed dose of 110 mg in patients 12 years of age and…
- Trial name
- NCT03052725
- Testing
- reslizumab
- Where
- 134 sites in United States, Belgium and 11 more
- Volunteers
- 391 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Qvar Versus Clenil, a General Practice Research Database Study
This study will compare the absolute and relative effectiveness of asthma management in patients on inhaled corticosteroid (ICS) maintenance therapy as either extra-fine-particle or larger-particle formulation beclomethasone…
- Trial name
- NCT01400217
- Testing
- extra fine particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler, standard particle particle hydrofluoroalkane beclomethasone dipropionate via metered dose inhaler
- Where
- United Kingdom
- Volunteers
- 56,985 people
- Sponsor
- Research in Real-Life Ltd
Asthma, Respiratory Tract Infections
VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that…
- Conditions
- Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup
- Trial name
- VICTORY (NCT06570889)
- Testing
- Cholecalciferol D3, Olive oil
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Professor Klaus Bønnelykke
Healthy, Asthma
Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma
The purpose of this study is to investigate the cytokine levels in nasal lavage and gene expression in nasal scraping following a single nasal dose of JNJ-43260295 in healthy participants, and in atopic mild to mild-persistent…
- Trial name
- NCT02243189
- Testing
- JNJ-43260295, Nasal Allergen Challenge
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Asthma
Asthma Origins and Remission Study
Asthma is characterized by chronic airway inflammation of the large and small airways. Asthma patients often have episodes with symptoms of dyspnea, wheezing and nocturnal awakening.
- Trial name
- ARMS (NCT03141814)
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Status Asthmaticus
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus
This study is a Phase I study to investigate the addition of inhaled Ipratropium bromide to standard therapy in the treatment of severe asthma attacks in children admitted to the Pediatric Intensive Care Unit.
- Trial name
- NCT02872597
- Testing
- Ipratropium, 0.9% Sodium Chloride, Albuterol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Asthma, Obesity
The Analysis of BMI, Asthma Prevalence, and Lung Functions of Schoolchildren in Southern Taiwan
The prevalence of obesity and asthma has increased in recent decades. We investigated the relationship between body mass index (BMI) and lung function, and also tried to determine if asthma prevalence differs between obese and…
- Trial name
- NCT00629785
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
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