Clinical trials: bipolar
Bipolar I Disorder
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients
The present study aims to evaluate the efficacy and safety of 8 mg endoxifen in the study population. As endoxifen represents a totally new class of drugs in the treatment of the bipolar disorder, it is essential to compare the…
- Trial name
- NCT04315792
- Testing
- Endoxifen
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Jina Pharmaceuticals Inc.
Tonsillitis
Outcomes of Bipolar Electrocautery Tonsillectomy Versus Cold Steel Dissection Pediatric Tonsillectomy
It was intended to practically establish whether or not the relatively newer technique of tonsillectomy like bipolar electrocautery tonsillectomy has any added benefits in reducing the duration of surgery, blood loss and…
- Trial name
- NCT06494839
- Testing
- Bipolar electrocautery tonsillectomy technique, Cold steel dissection technique
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- RESnTEC, Institute of Research
Post-Traumatic Stress Disorder
Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder in People With Additional Serious Mental Illnesses
This study will evaluate the effectiveness of tailored cognitive behavioral therapy in treating post-traumatic stress disorder in people with additional mental illnesses.
- Trial name
- NCT00494650
- Testing
- Cognitive behavioral therapy (CBT), Brief PTSD treatment
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Disorder
Metformin for Treatment Antipsychotic-induced Metabolic Syndrome in Bipolar Disorder Patients
The purpose of this study is to test the efficacy of metformin for treatment antipsychotic-induced metabolic syndrome in bipolar disorder patients.
- Trial name
- NCT02644577
- Testing
- Metformin, Starch
- Where
- China
- Volunteers
- 110 people
- Sponsor
- China Medical University, China
Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma
Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer
This phase I trial tests the change in androgen receptor sensitivity, side effects and effectiveness of bipolar androgen therapy, using testosterone, in patients with castration resistant prostate cancer that has spread to other…
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
- Trial name
- NCT06305598
- Testing
- Biopsy, Bone Scan, Computed Tomography
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Roswell Park Cancer Institute
Benign Prostate Hypertrophy(BPH)
Bipolar Enucleation of the Prostate Versus Bipolar TURP
Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large…
- Trial name
- TURP (NCT07718256)
- Testing
- bTURP, BEEP
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Pediatric Bipolar Disorder
Greater Houston Area Pediatric Bipolar Registry
The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD)…
- Trial name
- GHAPBR (NCT06665984)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Atrial Fibrillation
Correlation of Atrial Fibrillation Recurrence After Bipolar Radiofrequency Ablation With microRNA Expression
The recurrence rate of atrial fibrillation (AF) after bipolar radiofrequency ablation was about 30%. Besides the factors, left atrium diameter, the duration of AF, NT-proBNP, and ejection fraction(EF), some studies demonstrated…
- Trial name
- NCT04134793
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Bipolar Depression
Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression
The primary purpose of this study is to determine the safety and efficacy of oral RG2417 (Uridine) when administered to patients with Bipolar I depression twice daily for six weeks.
- Trial name
- NCT00322764
- Testing
- Uridine
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Repligen Corporation
Bipolar Disorder
A Six-Week Study Evaluating The Efficacy And Safety Of Geodon In Patients With A Diagnosis Of Bipolar I Depression
This is a 6-week trial that evaluates the efficacy and safety of Geodon (ziprasidone) in outpatient subjects ages 18 and older with Bipolar Disorder type I, depressed.
- Trial name
- NCT00141271
- Testing
- Geodon (Ziprasidone)
- Where
- 72 sites in United States
- Volunteers
- 536 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Schizophrenia, Bipolar Disorder
Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease
The validation of biomarkers allowing the discrimination of cognitive and behavioral disorders of psychiatric origin from those of neurodegenerative origin would facilitate diagnosis and improve patient management.
- Conditions
- Schizophrenia, Bipolar Disorder, Alzheimer Disease, FTD
- Trial name
- Nfl_COG (NCT04946916)
- Testing
- blood sample taken
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Hôpital le Vinatier
Bipolar Disorder
An Evaluation of Divalproex vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder
This study will evaluate how effective mood stabilizers are in the treatment of bipolar disorder with comorbid alcoholism
- Trial name
- NCT00221481
- Testing
- divalproex or olanzapine
- Where
- United States
- Sponsor
- Mayo Clinic
BD
The Effect of Methylphenidate on Cognitive Abilities of Adults With Bipolar Disorder
The purpose of the study is to explore the effect of MPH on working memory, attention and decision making in adults with BD in remission or in depressed state.
- Trial name
- NCT02020200
- Testing
- MPH
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shalvata Mental Health Center
Acute Bipolar Mania
Study of the Broad Clinical Benefit for Seroquel XR With Flexible Dose as an add-on Therapy in the Treatment of Acute Bipolar Mania Patients With Partial Response to Current Therapy
The primary objective of this study is to evaluate the broad clinical benefit of dosing Seroquel XR with flexible in the treatment of acute bipolar mania patients with partial response to existing therapy.
- Trial name
- RELEASE (NCT01128114)
- Testing
- Quetiapine fumarate (Seroquel XR)
- Where
- 11 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Bipolar Disorder
Effect of Probiotic vs Placebo on Cognition Outcomes in Patients With Bipolar Disorder
Bipolar disorder has a high hospitalization rate, suicide rate and disability rate, and cognitive dysfunction is one of the core clinical symptoms of bipolar disorder.
- Trial name
- NCT05954598
- Testing
- probiotic
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Rate of Complete Resection in a Unique Surgical Time
Comparison of Two Bipolar Resector in Less Than 3cm Myoma Resection
Hysteroscopic resection of type 0, 1 or 2 myoma is frequent. The more frequent resector used for myoma resection is 26Fr hysteroscope.
- Trial name
- DIAPER (NCT03402516)
- Testing
- 18.5 resector, 26Fr resector
- Where
- France
- Volunteers
- 308 people
- Sponsor
- Bicetre Hospital
Benign Prostatic Hyperplasia
Prostate Bipolar Enucleation and Resection Versus Open Prostatectomy
Benign prostatic hyperplasia (BPH) is a frequent disease in aging men accompanied by bladder outlet obstruction (BOO). Open prostatectomy (OP) is still considered the first-line treatment for more than 80 ml prostate size.
- Trial name
- NCT05416606
- Testing
- transurethral bipolar enucleation and resection of the prostate, open surgical transvesical prostatectomy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Bipolar Disorder, Schizophrenia
Non Interventional Study In Bipolar Disorder And Schizophrenia With Zeldox
Investigation of the impact of Zeldox on metabolic parametres in patients with bipolar disorder or with schizophrenia and impact of the treatment for the quality of life
- Trial name
- NCT00538629
- Testing
- no intervention
- Volunteers
- 471 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bipolar Disorder
An Evaluation of the Safety and Efficacy of Memantine in Patients With Acute Mania Associated With Bipolar I Disorder
Bipolar disorder affects 2.4 million adults in the USA between the ages of 18-65 and has considerable economic impact on our society.
- Trial name
- NCT00106405
- Testing
- Memantine HCl
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- Forest Laboratories
ADHD, BD
A Novel Psychological Intervention for Adults With Bipolar Disorder and Attention Deficit Hyperactivity Disorder Comorbidity (VECTOR)
Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning.
- Trial name
- VECTOR (NCT07039903)
- Testing
- Cognitive behavioral therapy (CBT) + Functional Remediation (FR)
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
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