Clinical trials: de Novo
Type 1 Diabetes, De Novo Lipogenesis
Pathogenesis of the Cardiometabolic Risk in Youth With Type 1 Diabetes
The purpose of this study is to quantitate hepatic de novo lipogenesis (DNL) in youth with poorly-controlled type 1 diabetes (T1D) (HbA1c >8.5%), youth with T1D who achieve targeted glycemic control (HbA1c <7.5%) and lean…
- Trial name
- NCT04101045
- Testing
- Oral Glucose Tolerance Test
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Yale University
Adolescent Obesity
Fructose-induced Hepatic De Novo Lipogenesis in Adolescents With Obesity
In the U.S., dietary fructose has increased in parallel with the increase in obesity and may promote the development of diabetes and other chronic diseases.
- Trial name
- NCT03567837
- Testing
- Fructose + Glucose Beverage
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Transplant; Failure, Kidney
A Pilot Study to Assess the Safety and Efficacy of Alefacept in de Novo Kidney Transplant Recipients
The purpose of this study is to assess Alefacept in combination with alemtuzumab induction and calcineurin inhibitor and corticosteroid withdrawal.
- Trial name
- NCT01163799
- Testing
- Alefacept (ASP0485)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Liver Metabolism
Alcohol Induced de Novo Lipogenesis in Women
The study is cross-sectional is design. In the first Aim of this study, 5 women and 5 men will be asked to consume 2g/kg of [2H]water (a.k.a.
- Trial name
- NCT04829110
- Testing
- ETOH, Sucrose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Peripheral Arterial Disease, Intermittent Claudication
Treatment of SFA Lesions With 480 Biomedical STANZA™ Drug-Eluting Resorbable Scaffold (DRS) System
An evaluation of the safety and performance of the STANZA Drug-eluting Resorbable Scaffold (DRS) system for the treatment of patients with obstructive superficial femoral artery disease.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Vascular Diseases, Cardiovascular Diseases
- Trial name
- SPRINT (NCT02097082)
- Testing
- STANZA Drug-eluting resorbable Scaffold
- Where
- 9 sites in Austria, Germany and 2 more
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- 480 Biomedical
Parkinson's Disease
Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects
Initially, the exploration of brain metabolism by Nuclear Magnetic Resonance Spectroscopy (MRS) of the high magnetic field proton (1H) (11.7T) applied to acute and chronic animal models of Parkinson's disease (PD) showed…
- Trial name
- METABO-NGC-7T (NCT04735172)
- Testing
- specific MRI Acquisition (NMR spectroscopy) at 7T
- Where
- 2 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Kidney Transplant, Renal Transplant Recipients
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients.
- Trial name
- RTB-006 (NCT03726307)
- Testing
- DCreg: 0.5 million cells/kg+SOC, DCreg: 1.2 million cells/kg+SOC, DCreg:2.5 to 5.0 million cells/kg+SOC
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Angus W. Thomson PhD DSc
Healthy Subjects
Effects of Exercise on Fructose Metabolism
A high fructose diet increases fasting and post-prandial triglyceride (TG) concentrations in sedentary healthy human subjects.These effects may be secondary to fructose-induced hepatic de novo lipogenesis.
- Trial name
- FruEx2 (NCT01866215)
- Testing
- exercise, fructose, glucose
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Dental Plaque, Dental Caries
Probiotic Treatment of Orthodontic Patients
The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients…
- Trial name
- NCT06751979
- Testing
- Probiotic treatment
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Left Main Coronary Artery Stenosis
eTryton Left Main Registry Tryton Side Branch Stent® Tmt of Denovo CAD in LM and CFX Arteries
The objective of this study is to demonstrate the clinical performance of the Tryton Side Branch Stent used in conjunction with a commercially available Drug Eluting Stent (DES) to treat de novo bifurcated lesions involving both…
- Trial name
- eTRYTONLM (NCT02765646)
- Testing
- Coronary stent procedure (CSP)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tryton Medical, Inc.
De Novo Lipogenesis (DNL), Lipid Metabolism
Implementation and Validation of an Analytical Protocol for Measuring de Novo Lipogenesis in the Liver Using Stable Isotopes
During this study, an analytical protocol for measuring hepatic de novo lipogenesis (DNL) using deuterium oxide (²H₂O) will be implemented and validated in healthy participants.
- Conditions
- De Novo Lipogenesis (DNL), Lipid Metabolism, Stable Isotope Tracing, Healthy Volunteers (HV)
- Trial name
- DNL (NCT07742423)
- Testing
- Deuterium oxide
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- KU Leuven
the Focus of the Study is Macrophage-induced Chemoresistance in Pancreatic Carcinoma Cells During Chemotherapy.
Macrophages Effect on Chemoresistance
Macrophages are derived from monocytes recruited to the tumor site and stimulated by specific chemokines secreted by tumor cells.
- Trial name
- NCT01921699
- Testing
- taking blood samples from healthy people
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Acne Vulgaris
De Novo Lipogenesis of Sebaceous Glands in Acne
There are two purposes of this study: 1. First, the investigators want to see what the differences are in de novo sebaceous lipid production of people with and without acne. 2.
- Trial name
- NCT02620813
- Testing
- Tretinoin, Isotretinoin
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Motor Learning, Corticospinal Excitability
Cortical Excitability During de Novo Motor Learning
De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch.
- Trial name
- StimNovoLearn (NCT07455461)
- Testing
- De novo motor learning
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
De Novo Lipogenesis (DNL)
Measurement of Lipogenic Flux by Deuterium Resolved Mass Spectrometry Via Non-invasive Breath Analysis
This proof of concept- study is to measure de novo lipogenesis (DNL) non-invasively in exhaled breath in overnight-fasted humans by triggering feeding response by deuterium resolved mass spectrometry.
- Trial name
- D2OBREATH (NCT05274334)
- Testing
- Assessment of de novo lipogenesis non-invasively in exhaled breath
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Hair Loss, Nails, Ingrown
Evaluation of the Efficacy of a New Supplement for Hair and Nails - in Vitro, Clinical, Subjective and Instrumental Study
A unicentric, exploratory, prospective clinical an in vitro study to evaluate efficacy and safety of a Supplement in improving the quality and general aspects of hair and nails in female participants through clinical,in vitro…
- Trial name
- NCT05945979
- Testing
- A power supplement with biotin
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Farmoquimica S.A.
Insulin Resistance, Obesity
De Novo Lipogenesis and Insulin Sensitivity in Obese
Disturbances of de novo lipogenesis (DNL) are one of the features of dysfunction of adipose tissue (AT). Disturbances of DNL play a role in development of metabolic complications of obesity.
- Trial name
- DELISA (NCT04260542)
- Testing
- Fasting/refeeding, Ketogenic diet/ fasting
- Where
- 2 sites in Czechia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Metabolic Syndrome X
Effects of Dietary Proteins on Hepatic Lipid Metabolism
Individuals submitted to a high-fat or a high-fructose/sucrose diet develop, over a 6 day-period, several features of the metabolic syndrome, including increased plasma triglycerides, increased intrahepatic lipids, and decreased…
- Trial name
- NCT00558740
- Testing
- high protein intake
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Metabolic Syndrome
Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism
10 healthy male volunteers will be studied after a 6 day weight maintenance, balanced diet a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day a 6 days weight maintenance, balanced…
- Trial name
- AMINOFRUCT (NCT01119989)
- Testing
- amino-acid + fructose
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Obesity
Fructose-induced Intestinal de Novo Lipogenesis
8 healthy volunteers, 8 pre-bypass obese subjects, 8 subjects between 12-18 months post-bypass, and 8 subjects matched to the post-bypass patients will be studied in two sub-studies Sub-study 1) after ingestion of two or three…
- Trial name
- FIDNL (NCT01792089)
- Testing
- fat+protein meal, Fat + protein + 13C fructose meal, Fat+protein+13C fructose+glucose meal
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Lausanne