Clinical trials: malaria
Malaria
Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal
The purpose of this trial is to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children.
- Trial name
- NCT00529620
- Testing
- sulfalene-pyrimethamine plus amodiaquine, dihydroartemisinin plus piperaquine, sulfadoxine pyrimethamine plus piperaquine
- Where
- Senegal
- Volunteers
- 1,833 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria,Falciparum
Safety, Immunogenicity and Efficacy of R21 Matrix-M in 5-17 Month Old Children in Nanoro, Burkina Faso
This is a double blind randomised controlled clinical trial to evaluate the efficacy of R21 adjuvanted with Matrix-M in healthy 5-17 month old children in a malaria endemic area.
- Trial name
- NCT03896724
- Testing
- R21 adjuvanted with 25mcg Matrix-M, Rabies Vaccine, R21 adjuvanted with 50mcg Matrix-M
- Where
- Burkina Faso
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Asymptomatic Parasitemia In Pregnancy
Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa
The study will be conducted in asymptomatic pregnant women with P. falciparum parasitemia. The subjects will be given 3 day dosing regiment of the fixed-dose combination of Azithromycin and Chloroquine.
- Trial name
- NCT01103713
- Testing
- Azithromycin plus chloroquine
- Where
- 7 sites in Benin, Kenya and 3 more
- Volunteers
- 168 people
- Sponsor
- Pfizer
Malaria
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo
This will be an open-randomised non-inferiority study to test the hypothesis that the risk of recurrent parasitaemia after 42 days is not worse in the group receiving the Artesunate-Amodiaquine (ASAQ) regimen than in the group…
- Trial name
- NCT02741024
- Testing
- Amodiaquine-Artesunate (ASAQ), Artemether-Lumefantrine (AL)
- Volunteers
- 288 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Malaria, Diarrhea
Liberia National Community Health Assistant (NCHA) Program and Under-five Mortality
Last Mile Health (LMH) has partnered with the Liberian Ministry of Health (MOH) to support the design and implementation of the National Community Health Assistant Program (NCHAP).
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection, Malnutrition, Child
- Trial name
- NCT05123378
- Testing
- Liberia National Community Health Assistant Program
- Where
- Liberia
- Volunteers
- 23,702 people, healthy volunteers welcome
- Sponsor
- Last Mile Health
Healthy Volunteer, HV
Improving the Efficacy of Experimental Malaria Vaccine AMA1-C1/Alhydrogel® (Registered Trademark)
This study will evaluate the safety and efficacy of the experimental malaria vaccine AMA1-C1/Alhydrogel® (Registered Trademark) and determine whether a new, additional component of the vaccine may increase its effectiveness.
- Trial name
- NCT00340574
- Testing
- AMA1-C1/Alhydrogel + CpG 7909
- Where
- 2 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Cluster Randomized Trial of Peer Health Education in Malaria in The Gambia
Health promotion in schools aims to improve the health and well being of students by empowering them with the knowledge, skills and confidence to take responsibility for their own health.
- Trial name
- NCT00269178
- Testing
- Peer Health Education Programme
- Where
- The Gambia
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Merozoite Surface Protein 1 Antibody Response in Asymptomatic Human Malaria Infection
The main purpose of this trial is to study whether a certain blood test can reliably identify the presence of malaria in people who have been infected with, but who do not have symptoms of malaria.
- Trial name
- NCT00761020
- Testing
- Mefloquine, Control
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
Perennial Malaria Chemoprevention (PMC) Effect Study
The Malaria Consortium Nigeria (MC) will coordinate a trial of PMC in Osun State, Nigeria with strategic support from the National Malaria Elimination Programme of the Government of Nigeria (NMEP) and financial support from the…
- Trial name
- PMCEffect (NCT06155448)
- Testing
- Perennial Malaria Chemoprevention effect
- Where
- Nigeria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Flavivirus Infection, Alphavirus Infections
The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
The study project can be divided into two parts: (1) health screening for the community and (2) clinical diagnosis and treatment for patients at National Referral Hospital (NRH) in Solomon islands.
- Conditions
- Flavivirus Infection, Alphavirus Infections, Malaria, Parasitic Disease
- Trial name
- NCT01080989
- Testing
- diagnosis, treatment and education
- Where
- Taiwan
- Volunteers
- 1,477 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Malaria,Falciparum
Performance of an Ultrasensible Malaria Rapid Diagnostic Test Among Pregnant Women in Burkina Faso
The goal of this observational study is to learn about the diagnostic performance of the highly sensitive rapid diagnostic test (HS-RDT) compared to an ultrasensitive qPCR for detection of falciparum malaria in pregnant women…
- Trial name
- HS-RDT-MiP (NCT06572644)
- Where
- Burkina Faso
- Volunteers
- 288 people
- Sponsor
- Centre MURAZ/Institut National de Santé Publique
Falciparum Malaria, Uncomplicated Malaria
Phase II Dose Ranging Study of Artesunate
The purpose of this study is to compare four regimens using US FDA GMP intravenous artesunate for the treatment of uncomplicated Plasmodium falciparum malaria to identify the most effective treatment regimen as determined by…
- Trial name
- NCT00459615
- Testing
- Artesunate for Injection
- Where
- 2 sites in Kenya, Thailand
- Volunteers
- 120 people
- Sponsor
- U.S. Army Office of the Surgeon General
Uncomplicated P. Falciparum Malaria
SPK Study in Afghanistan
In Afghanistan, studies over the past 15 years have shown a high degree of Plasmodium falciparum resistance to chloroquine. In 2003 the high failure rate of chloroquine against falciparum malaria led the national malaria…
- Trial name
- NCT01707199
- Testing
- Artesunate + Sulphadoxine-pyrimethamine
- Where
- Afghanistan
- Volunteers
- 83 people
- Sponsor
- University of Oxford
Malaria, Malaria,Falciparum
Malawi International Center of Excellence in Malaria Research School-based Cohort
A school-based, prospective, cohort study was conducted to evaluate the epidemiology of P. falciparum (Pf) infections in school-age children and determine the impact of the screen-and-treat approach on Pf infection and anemia…
- Conditions
- Malaria, Malaria,Falciparum, Anemia
- Trial name
- NCT04858087
- Testing
- Screening and treatment
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Plasmodium Falciparum Malaria
Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic
This study assesses the effectiveness of targeted active case detection among high-risk populations in Southern Lao Peoples Democratic Republic (PDR).
- Trial name
- NCT03783299
- Testing
- Standard RDT and HS-RDT, Artemether-lumefantrine, Primaquine Phosphate
- Where
- Laos
- Volunteers
- 39,968 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Malaria Vaccines
A Study Assessing the Safety, Efficacy, and Impact of GlaxoSmithKline Biologicals' RTS, S/AS01E Malaria Vaccine in Young Children Across Sub-Saharan Africa
The RTS, S/AS01E vaccine was developed to protect children in sub-Saharan Africa from malaria as part of routine immunization programs. This study aims to check the vaccine's safety after it has been introduced.
- Trial name
- EPI-MAL-003 (NCT03855995)
- Testing
- Whole blood sample
- Where
- 6 sites in Ghana, Kenya and 1 more
- Volunteers
- 77,953 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Efficacy of Artesunate + Amodiaquine Four Years After Its Introduction in Zanzibar
The purpose of this study is to assess the efficacy of artesuante + amodiaquine four years after its introduction as first line treatment for uncomplicated childhood malaria in Zanzibar.
- Trial name
- NCT00465257
- Testing
- artesunate + amodiaquine
- Where
- Tanzania
- Volunteers
- 110 people
- Sponsor
- Karolinska University Hospital
Malaria, HIV Infections
Interactions Between HIV and Malaria in African Children
This is a prospective cohort study where HIV-infected and uninfected children will be enrolled between 6 weeks and 9 months of age and followed to the age of 21 months.
- Trial name
- TCC (NCT00527800)
- Testing
- Dihydroartemisinin-piperaquine, Artemether-lumefantrine, Trimethoprim-sulfamethoxazole
- Where
- Uganda
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Chemoprophylactic Activity of M5717 in PfSPZ Challenge Model
The main purpose of this study was to assess the chemoprophylactic activity and dose-exposure-response relationship of single oral dose of M5717 administered after direct intravenous inoculation (DVI) of Plasmodium falciparum…
- Trial name
- NCT04250363
- Testing
- PfSPZ Challenge, Palcebo, M5717 30 mg
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Malaria
Phase I Study of Safety and Immunogenicity of AMA1-C1Alhydrogel + CPG 7909 Vaccine for Malaria
This study will evaluate the safety of an experimental vaccine can protect people from malaria and study its effects. Malaria, which affects many people in Mali and other countries in Africa, is caused by germs spread by mosquito…
- Trial name
- NCT00414336
- Testing
- AMA1-C1/Alhydrogel + CPG 7909 Vaccine
- Where
- Mali
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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