Clinical trials: miRNAs
Autism Spectrum Disorder, Developmental Delay
Improving Autism Screening With Brain-Related miRNA
The goal of this project is to identify specific miRNAs that are increased or decreased in the saliva of children with developmental delay and are useful for screening toddlers for ASD.
- Trial name
- NCT02712853
- Testing
- Saliva collection, Vineland Adaptive Behavior Scale-II Assessment
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Autism Spectrum Disorder, Developmental Delay
A Salivary miRNA Diagnostic Test for Autism
The goal of this study is to validate a panel of miRNAs that distinguish children with autism spectrum disorder (ASD) from their non-ASD peers with a positive MCHAT-R.
- Trial name
- NCT02832557
- Testing
- Salivary collection, Vineland Adaptive Behavior Scale-III Assessment, Medical history questionaire
- Where
- United States
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury
Efforts to identify circulating factors that predict severity of acute lung injury/acute respiratory distress syndrome（ALI/ARDS）patients is unrevealing.
- Trial name
- TRCCMALI (NCT03766204)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Hypertonic Saline, Isotonic Saline
Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)
In this experiment, the investigators would like to test the following: 1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ? 2.
- Trial name
- miRNA (NCT04439994)
- Testing
- hypertonic saline, Saline injection, Blood sampling
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Asthma, COPD
Circulating Micro RNAs Expression in Egyptian Bronchial Asthma and COPD Patients
This cross sectional study will be carried out on 30 subjects who will be recruited from the outpatient clinic of Chest Department, Tanta University Hospital.
- Trial name
- NCT02719145
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Oral Submucous Fibrosis
Epithelial Mesenchymal Transition Markers in OSMF
Oral Sub mucous Fibrosis (OSMF) is essentially an imbalance between collagen metabolism and wound healing mechanism induced by arecanut chewing habit.
- Trial name
- NCT03732872
- Testing
- Biopsy tissue analysis, Saliva analysis
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Cardiovascular Diseases, Periodontal Diseases
Impact of Periodontal Treatment on Local miRNA Expression
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA…
- Trial name
- NCT05275127
- Testing
- changes of gingival crevicular fluid miRNA
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Catania
Non-Viable Pregnancy
Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy
Ectopic pregnancy (EP) is a pathology that affects 3%-16% of pregnancies in humans, being the main cause of morbidity and maternal mortality in the first trimester of pregnancy worldwide.
- Trial name
- TESTKM (NCT03877939)
- Testing
- Blood samples collection for analysis
- Where
- 2 sites in Spain
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Thoracic Cancer, Ovarian Cancer
Project CADENCE (CAncer Detected Early caN be CurEd)
With existing evidence showing the difference in miRNA expression levels between non-cancer and cancer groups, the investigators assume that levels of DNA methylation, RNA expression as well as protein concentration will also be…
- Conditions
- Thoracic Cancer, Ovarian Cancer, Liver Cancer, Prostate Cancer
- Trial name
- CADENCE (NCT05633342)
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- MiRXES Pte Ltd
Obstructive Sleep Apnea
Extracellular microRNA: Biomarkers of Endothelial Dysfunction in Obese Adolescents & Adults With Obstructive Sleep Apnea
Using a prospective observational approach and a clinical trial design comparing the effectiveness of continuous positive airway pressure to diet and exercise, investigators plan to evaluate how obstructive sleep apnea (OSA)…
- Trial name
- NCT03546751
- Testing
- Continuous Positive Airway Pressure, Diet And Exercise
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Chronic Fatigue Syndrome (CFS)
MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome (CFS)
MicroRNAs were shown to play an important role in regulating pain-processing in a wide range of experimental models and clinical pain disorders.
- Trial name
- CFs (NCT03892954)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King Saud University
Healthy
Effect of Exercise Intensity on Epigenetic Response in Healthy Young Adult
Aerobic exercise has been shown to trigger a variety of body responses which then trigger physiological adaptations. One of the physiological adaptations that occur is an increase in mitochondrial biogenesis.
- Trial name
- NCT04985006
- Testing
- running at moderate intensity, running at high intensity
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rahmaningsih Mara Sabirin
Parkinson Disease
Parkinson Disease Before and After Medication and Rehabilitation Treatment
In this three-year project, our research teams are going to consecutively explore these important clinical, drug and physical rehabilitation treatment effects, noradrenergic network, autonomic dysfunction and microRNA signalling…
- Trial name
- NCT02672943
- Testing
- Rehabilitation treatment, non-rehabilitation treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Periodontal Diseases, Periodontitis
miRNAs in Periodontal Disease
It has been stated that microRNA (miRNA) play an important role in development, homeostasis and immune functions, and abnormal miRNA expression may cause faster disease progression.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT05046678
- Testing
- Control, Smokers with periodontally healthy, Non-smokers with gingivitis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Esophageal Cancer, Gastric (Stomach) Cancer
Establishment of Molecular Classification Models for Early Diagnosis of Digestive System Cancers
This is a single blind, case control, multicenter study jointly developed by Zhongshan Hospital of Fudan University, Shanghai Public Health Clinical Center, Shanghai Xuhui Central Hospital, Qingpu Branch of Zhongshan Hospital…
- Conditions
- Esophageal Cancer, Gastric (Stomach) Cancer, Colorectal Cancer, Hepatocellular Carcinoma
- Trial name
- NCT05431621
- Where
- 4 sites in China
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Atherosclerosis of Artery
microRNAs in the Diagnosis of Atherosclerotic Plaque Instability
It's a non-randomized, intervention, prospective, single-center study. The aim of the work is to identify of biomarkers of unstable atherosclerosis in brachiocephalic arteries Tasks: identify microRNAs, the expression of which is…
- Trial name
- NCT05680935
- Testing
- blood microRNA, plaque and intima microRNA, histological examination of the plaque
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Smoking, Smoking Cessation
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nose and miRNAs in Blood
Smoking cessation improves health conditions with reduction of the risk factors for cardiovascular and respiratory disease, as functional capacity and quality of life.
- Trial name
- NCT02136550
- Testing
- Smoking cessation
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo