Clinical trials: in Rwanda
Severe Malaria
To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria
The purpose of this study was to identify the safe and effective dose of intravenous cipargamin in participants with moderately severe and severe malaria.
- Trial name
- NCT04675931
- Testing
- Cipargamin, IV Artesunate, Coartem
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 5 more
- Volunteers
- 254 people
- Sponsor
- Novartis Pharmaceuticals
IPV, Mental Health
Rwanda Digital Dashboard Hybrid Type 3 Implementation Study
Mental disorders are leading causes of the health-related burden globally, and in Rwanda the intergenerational mental health consequences of the 1994 Genocide against the Tutsi persist and are further compounded by poverty, such…
- Conditions
- IPV, Mental Health, Discipline Practices, Quality Assurance
- Trial name
- NCT06941831
- Testing
- Digital Dashboard-Supported Sugira Muryango Implementation, Usual Care - Sugira Muryango Implementation
- Where
- Rwanda
- Volunteers
- 1,810 people, healthy volunteers welcome
- Sponsor
- Boston College
Emergencies, Injuries
The Impact of First Aid Blended Learning Training on Learning Outcomes and Helping Behaviour of Adult Laypeople in Rwanda
The goal of this study is to assess the impact of a first aid training delivered through a blended learning approach on learning outcomes and helping behaviour in adult laypeople in Rwanda.
- Conditions
- Emergencies, Injuries, Illness Physical
- Trial name
- NCT06003504
- Testing
- First aid training with blended learning approach, First aid training with face-to-face approach
- Where
- Rwanda
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Centre for Evidence-Based Practice, Belgium
Acute Hypoxemic Respiratory Failure
Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is one of the prevalent causes of admission around the world and is associated with high mortality in resource-limited settings.
- Trial name
- BAGCPAP-R (NCT07460427)
- Testing
- Bag CPAP, Standard oxygen
- Where
- Rwanda
- Volunteers
- 250 people
- Sponsor
- Prof RWABIHAMA Jean Paul
Tetanus
TETANUS Antibody Detection in Saliva Study
This study aims to design, develop and optimise a non-invasive, saliva sample-based point-of-care lateral flow test for use in low and middle income settings that can return a qualitative result on whether an individual has or…
- Trial name
- TETANUS (NCT07446166)
- Testing
- Point of care, saliva-based lateral flow test, Blood based immunoassay
- Where
- Rwanda
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Surgery, Inpatients
EMUs: Enhanced Monitoring Using Sensors After Surgery
Patients can become critically unwell following surgical operations. Delay in recognition of this deterioration can result in patient harm and even death.
- Trial name
- EMUs (NCT06565559)
- Testing
- Wearable Wireless Sensor
- Where
- 17 sites in Benin, Ghana and 6 more
- Volunteers
- 1,332 people
- Sponsor
- University of Edinburgh
Hypoxemia, Morality
Health Systems and Policy Contexts of Medical Oxygen
This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies.
- Conditions
- Hypoxemia, Morality, Pneumonia
- Trial name
- MOXY-HSP (NCT06169514)
- Testing
- No intervention
- Where
- 6 sites in Cambodia, Laos and 4 more
- Volunteers
- 1 people
- Sponsor
- Murdoch Childrens Research Institute
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KLU156 in Adults and Children With Uncomplicated P. Falciparum Malaria
This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for…
- Trial name
- KALUMA (NCT05842954)
- Testing
- KLU156, Coartem
- Where
- 33 sites in Burkina Faso, Côte d’Ivoire and 10 more
- Volunteers
- 1,720 people
- Sponsor
- Novartis Pharmaceuticals
Blood Pressure, Lung Function
Sustainable Household Energy Adoption in Rwanda (SHEAR)
Investigators will conduct a randomized controlled trial substituting traditional forms of household energy (biomass for cooking and kerosene for lighting) with liquified petroleum gas (LPG) stoves/fuel and solar power (in areas…
- Trial name
- SHEAR (NCT05668624)
- Testing
- Clean household energy
- Where
- Rwanda
- Volunteers
- 1,680 people
- Sponsor
- Colorado State University
Human Papilloma Virus, Hiv
Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV.
The Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study is evaluating immediate or delayed single-dose…
- Trial name
- HOPE II (NCT06436274)
- Testing
- GARDASIL®9, Menveo®/Menactra®
- Where
- 3 sites in Botswana, Rwanda and 1 more
- Volunteers
- 778 people
- Sponsor
- Massachusetts General Hospital
Hiv
HIV-1 Subtype-specific Drug Resistance in Patients Failing Dolutegravir (DTG) Based Regimen
This is a prospective observational study enrolling People Living with HIV (PLHIV) who are on a Dolutegravir-based AntiRetroviral Treatment (ART) regimen and experiencing virologic failure.
- Trial name
- DTG-Resist (NCT06285110)
- Where
- 22 sites in Argentina, Brazil and 14 more
- Volunteers
- 1,103 people
- Sponsor
- University of Bern
Plasmodium Falciparum Malaria (Uncomplicated)
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs.
A partially blinded randomised controlled non-inferiority trial comparing the efficacy, tolerability and safety of Triple ACTs artemether-lumefantrine+amodiaquine (AL+AQ) and artesunate-mefloquine+piperaquine (ASMQ+PPQ) and the…
- Trial name
- DeTACT-Africa (NCT03923725)
- Testing
- Artemether-lumefantrine+ Amodiaquine (AL+AQ), Artesunate-mefloquine+piperaquine (AS-MQ+PPQ)
- Where
- 8 sites in Burkina Faso, Democratic Republic of the Congo and 6 more
- Volunteers
- 2,583 people
- Sponsor
- University of Oxford
Uncomplicated Plasmodium Falciparum Malaria
A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines
The goal of this open-label randomised, controlled, non-inferiority trial is to assess and compare the efficacy, tolerability and safety of a fixed dose TACT artemether-lumefantrine-amodiaquine (ALAQ) to the ACTs…
- Trial name
- FD-TACT (NCT05951595)
- Testing
- Artemether-Lumefantrine-Amodiaquine (ALAQ), Artemether-Lumefantrine (AL), Artesunate-Amodiaquine (ASAQ)
- Where
- Rwanda
- Volunteers
- 1,680 people
- Sponsor
- University of Oxford
Cervical Cancer, Human Papilloma Virus
HPV Vaccine Effectiveness Study in Rwandan Women Living With HIV
Our study will assess and measure population effectiveness of prophylactic HPV vaccine in reducing cervical, anal, and/or oral prevalent and 6-month persistent infections among HPV-vaccinated and 757 HPV-unvaccinated Rwandan WLWH…
- Conditions
- Cervical Cancer, Human Papilloma Virus, Human Immunodeficiency Virus, HPV-Related Carcinoma
- Trial name
- NCT05247853
- Testing
- Blood collection, Oral, cervicovaginal and anal specimen collection, Anoscopy & Biopsy of Acetowhite Lesions
- Where
- Rwanda
- Volunteers
- 3,127 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Malaria
A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months
The purpose of this study is to evaluate the safety and immunogenicity of reduced antigen doses and alternative vaccination regimes for RTS,S/AS01E in healthy children aged 5-60 months in a malaria-endemic area.
- Trial name
- NCT07036159
- Testing
- RTS,S/AS01E vaccine
- Where
- 2 sites in Rwanda
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Disease Progression
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
- Trial name
- REVIVE (NCT05580666)
- Testing
- Azithromycin Oral Tablet
- Where
- 52 sites in Côte d’Ivoire, Ethiopia and 9 more
- Volunteers
- 8,000 people
- Sponsor
- Population Health Research Institute
Cognitive Change, Growth; Stunting, Nutritional
The Sugira Muryango Longitudinal & Spillover Study
The Early Childhood version of Sugira Muryango is a family-based, home-visiting intervention targeted at early childhood development and implemented with families living in extreme poverty in three districts of Rwanda.
- Conditions
- Cognitive Change, Growth; Stunting, Nutritional, Language, Depression
- Trial name
- NCT05405400
- Where
- 3 sites in Rwanda
- Volunteers
- 2,932 people, healthy volunteers welcome
- Sponsor
- Boston College
HIV, Viral Load
East Africa Point of Care Viral Load Study
The purpose of EAPoC-VL project is to examine the feasibility, acceptability, and effectiveness of using point of care viral load (PoC VL) monitoring to improve viral load suppression among children, adolescents and young people…
- Conditions
- HIV, Viral Load, Point of Care Monitoring
- Trial name
- EAPoC-VL (NCT05048472)
- Testing
- Abbott HIV-1/2 VL Point of care Device
- Where
- 7 sites in Kenya, Rwanda and 2 more
- Volunteers
- 956 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Child Health
Dynamic CDSA to Manage Sick Children in Rwanda
This study aims to reduce morbidity and mortality among children and mitigate antimicrobial resistance using a novel clinical decision support algorithm, enhanced with point-of-care technologies to help health workers in primary…
- Trial name
- DYNAMIC-RW (NCT05108831)
- Testing
- ePOCT+
- Where
- 39 sites in Rwanda
- Volunteers
- 85,212 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Strongyloides Stercoralis Infection, Strongyloides
Strongyloides Stercoralis Public Health Control in Rwanda
The World Health Organization (WHO) recently issued guideline for the public health control of Strongyloides stercoralis in endemic areas.
- Trial name
- SCAN (NCT07009613)
- Testing
- Parasitological tests, Questionnaire
- Where
- Rwanda
- Volunteers
- 1,415 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar