Clinical trials: in Rwanda
Epilepsy
Risk Factors and Etiologies of Epilepsy in Urban and Rural Rwanda
Epilepsy is one of the most common chronic brain disorders. Up to 85% of persons living with epilepsy (PwE) live in the developing world. In sub-Saharan Africa (SSA), Rwanda has one of the highest prevalence rates (±5%).
- Trial name
- REpiCa (NCT05698537)
- Testing
- EEG, Neuroimaging, Blood sample
- Where
- Rwanda
- Volunteers
- 1,745 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Surgical Site Infection
A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI
MARLIN is a stratified, multi-arm, multi-stage factorial randomised platform trial aiming to reduce the incidence of post-operative surgical site infection (SSI).
- Trial name
- MARLIN (NCT06465901)
- Testing
- Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower, Intraoperative wound wash (e.g. Granudacyn), DACC surgical wound dressing (e.g. Leukomed Sorbact)
- Where
- 7 sites in Benin, Ghana and 5 more
- Volunteers
- 10,092 people
- Sponsor
- University of Birmingham
Fractures or Dislocations
INternational ORthopaedic MUlticenter Study in Fracture Care (INORMUS)
Background: Worldwide, injuries from trauma represent a major public health problem. The World Health Organization (WHO) has deemed this problem as one of the most important global priorities, calling 2011-2020 the 'Decade of…
- Trial name
- INORMUS (NCT02150980)
- Where
- 69 sites in Argentina, Botswana and 24 more
- Volunteers
- 39,797 people
- Sponsor
- McMaster University
Metabolic Syndrome, Nutritional Status
Dietary Practices and Metabolic Syndrome in the Young Adult Population of Rwanda
Policy makers in Rwanda have recently highlighted the importance of promoting healthy diets and lifestyle in response to rapidly increasing rates of obesity.
- Conditions
- Metabolic Syndrome, Nutritional Status, Diet Habit
- Trial name
- NutriTransit (NCT04204538)
- Testing
- Dietary habits, Risk factors associated with metabolic syndrome
- Where
- Rwanda
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- University Ghent
Uncomplicated Malaria
Malaria Therapeutic Efficacy Study, Rwanda
WHO recommends that Therapeutic Efficacy Studies (TES) for 1st and 2nd line antimalarial medicines should be routinely carried out and data made available for decision-making due to the threat of emergence and spread of…
- Trial name
- NCT04767217
- Testing
- artemether-lumefantrine (ALN), dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 3 sites in Rwanda
- Volunteers
- 528 people
- Sponsor
- Jhpiego
Malaria, Diagnoses Disease
Clinical Validation of Novel Malaria Diagnostic Tools for POC Point-of-Care Testing
The aim of this study is to perform a performance evaluation of novel diagnostic tools for detecting malaria in malaria-endemic countries.
- Conditions
- Malaria, Diagnoses Disease, RDT
- Trial name
- NCT06225700
- Where
- Rwanda
- Volunteers
- 509 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Mental Disorder
Validation of Instruments for Clinical Trial on Patients With Bipolar Disorder in Rwanda
This study evaluates the cultural and linguistic sensitivity and psychometric properties of a set of four adapted measurement instruments essential to determining the efficacy of group-psychoeducation for patients with bipolar…
- Trial name
- NCT04834999
- Testing
- Validation of questionnaires in Kinyarwanda
- Where
- Rwanda
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Malaria
Innovation Platform
In this study, a prospective evaluation of novel malaria diagnostic tools under development will be performed in malaria-endemic countries to assess their clinical performance for detection of malaria at point-of-care (POC).
- Trial name
- NCT04558528
- Testing
- Novel in vitro diagnostics and medical applications
- Where
- 2 sites in Indonesia, Rwanda
- Volunteers
- 640 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Hiv, Aids
Reducing Time to Spaced-out Appointments for Newly-diagnosed People Living With HIV
The objectives of this study are to pilot test the effect of reducing time to spaced-out appointments from 18 to 6 months for newly-diagnosed people living with HIV (PLWH) in Rwanda who have initiated antiretroviral therapy…
- Trial name
- NCT04567693
- Testing
- Early spaced-out appointments
- Where
- Rwanda
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
HIV Infections
Evaluation of HIV-1 Recent Infection Testing in Rwanda
The study is a longitudinal, observational cohort study of people who are newly-diagnosed with HIV who consent to recency testing and participate in index testing services, and their disclosed contacts.
- Trial name
- NCT05063487
- Testing
- Return of recent classification, Return of long-term classification
- Where
- Rwanda
- Volunteers
- 1,588 people
- Sponsor
- Columbia University
Soil-transmitted Helminth Infections
Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP2 (NCT04177654)
- Testing
- Benzimidazoles
- Where
- 8 sites in Bangladesh, Cambodia and 6 more
- Volunteers
- 9,457 people
- Sponsor
- University Ghent
Cancer Pain
A Novel mHealth Approach to Assess and Manage Palliative Care Needs for Cancer Patients in Kigali
Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness such as cancer, through the prevention and relief of suffering by means…
- Trial name
- NCT03367637
- Testing
- Standard palliative care, Smart Phone based symptom evaluation application
- Where
- Rwanda
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
Psychoeducation for Patients With Bipolar Disorder in Rwanda
Background: Mental health- and neurological disorders constitute 13% of the global burden of disease. Alarmingly this burden has risen by 41% in the last 20 years.
- Trial name
- NCT04671225
- Testing
- Groups Psychoeducation, Waiting-list
- Where
- 2 sites in Rwanda
- Volunteers
- 154 people
- Sponsor
- University of Aarhus
Tuberculosis, Multidrug-Resistant
Preventing Acquired Resistance: Strengthen TB Treatment by Adding Amikacin in the First Treatment Week of Multidrug-resistant Tuberculosis
Acquired drug-resistance is a major challenge for tuberculosis (TB) care programs. The 2020 WHO guidelines recommends replacing second-line injectables by bedaquiline in rifampicin-resistant TB (RR-TB) treatment regimens.
- Trial name
- Stake (NCT05555303)
- Testing
- Amikacin
- Where
- Rwanda
- Volunteers
- 20 people
- Sponsor
- Rwanda Biomedical Centre
Tuberculosis, Multidrug-Resistant
DIAgnostics for Multidrug Resistant Tuberculosis in Africa
Recent advances in molecular diagnostics of tuberculosis, especially the GeneXpert Mycobacterium tuberculosis/Rifampicin test have reduced the time to diagnose Rifampicin Resistant Tuberculosis (RR-TB) but only rifampicin…
- Trial name
- DIAMA (NCT03303963)
- Testing
- Deeplex test, MolBio TrueNat for 2nd line, GeneXpert 2nd line, Fluorescein DiAcetate (FDA) Microscopy,GeneXpert Ct value, pre-rRNA synthesis
- Where
- 10 sites in Belgium, Benin and 8 more
- Volunteers
- 3,356 people
- Sponsor
- Dissou AFFOLABI
HIV-1-infection
A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)
A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health.
- Trial name
- NCT05414786
- Testing
- eOD-GT8 60mer mRNA Vaccine (100µg)
- Where
- 2 sites in Rwanda, South Africa
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda
The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance in mosquito populations to commonly used insecticides.
- Trial name
- NCT04230161
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Indoor residual spraying
- Where
- Rwanda
- Volunteers
- 3,502 people, healthy volunteers welcome
- Sponsor
- PATH
Global Health, Education
Can VAST Improve ACLS in Rwanda
Aim The purpose of this study is to determine if the addition of the VAST Course to technical resuscitation skills training enhances healthcare providers' resuscitation performance in a resource-limited setting.
- Conditions
- Global Health, Education, Resuscitation
- Trial name
- NCT05278884
- Testing
- Advanced Cardiac Life Support Training, Vital Anesthesia Simulation Training
- Where
- Rwanda
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Toronto
First Aid Education for Road Traffic Crashes
Effectiveness of Road Traffic Crashes First-aid Education Among Commercial Motorcyclists in Kigali-City, Rwanda
Prehospital management after road traffic crashes(RTC) is a predicting factor to patient outcomes especially in Low-Income Countries where emergency medical services are lacking.
- Trial name
- NCT04932239
- Testing
- first aid education
- Where
- Rwanda
- Volunteers
- 200 people
- Sponsor
- Universiti Putra Malaysia
Dietary Assessment
Dietary Assessment in Rwanda - Food Frequency Questionnaire
The burden of non-communicable diseases (NCDs) in Rwanda is adding to the health burden in the country which is facing the nutritional transition and the double burden of malnutrition.
- Trial name
- FFQ Rwanda (NCT04202107)
- Testing
- Food Frequency Questionnaire, 24 Hour food recall
- Where
- Rwanda
- Volunteers
- 200 people
- Sponsor
- University Ghent