Clinical trials: Standard treatment
HIV Infection
A Randomized Controlled Trial of the Bruthas Project
African American men who have sex with men and women (AAMSMW) are at particular risk for contracting and transmitting HIV, and represent a priority population for developing effective interventions.
- Trial name
- NCT01270230
- Testing
- Bruthas Project, Standard HIV Testing and Counseling
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lateral Epicondylitis, Tendinosis
PRINT Trial (Platelet Rich Injection vs Needle Tenotomy)
Chronic tendinopathy is often very difficult to treat and causes many patients who suffer from it to have significant pain and loss of function leading to disability.
- Conditions
- Lateral Epicondylitis, Tendinosis, Elbow, Tennis, Elbows Tendonitis
- Trial name
- PRINT (NCT03504111)
- Testing
- Percutaneous Needle Tenotomy, PRP
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Infection, Drainage
Comparison of Negative Pressure Wound Therapy vs. Conventional Dressings for Prevention of Wound Complications After Revision THA
Wound complications and surgical site infections following revision total joint arthroplasty result in significant morbidity and cost.
- Trial name
- NCT03321799
- Testing
- Negative Pressure Wound Therapy (NPWT), Sterile Antimicrobial Dressings
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy Nutrition
Effect of Ketogenic Diet on Muscle Hypertrophy
The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact…
- Trial name
- NCT05897567
- Testing
- resistance training, ketogenic diet, western diet
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Padova
Primary Dysmenorrhea (PD)
Individualized Acupoint Therapy for Dysmenorrhea: An Exploratory Research Design Based on Meridian Measurement
Primary dysmenorrhea is a common condition that significantly affects young women's quality of life. Traditional Chinese Medicine (TCM) acupoint interventions are widely used for symptom relief; however, standardized…
- Trial name
- NCT07818044
- Testing
- TI-816-3E3 Portable Laser Phototherapy Device
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Hepatitis C, Atherosclerosis
Counseling Hepatitis C Virus (HCV) Positive Patients for Cardiovascular Disease Risk Factors
The study aims to compare the effect of a cardiovascular education package intervention on treatment-seeking behavioral outcomes of HCV+ patients.
- Trial name
- NCT03402334
- Testing
- Patient counseling for HCV associated CVD risk factors
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Tulane University
Glaucoma, Diabetic Retinopathy
Providing Financial Incentives to Improve Adherence to Referral Eye Care Visits
Glaucoma is a blinding eye disease increasingly common in older adults, particularly in African Americans, and often diagnosed late in the disease course.
- Conditions
- Glaucoma, Diabetic Retinopathy, Refractive Errors, Cataract
- Trial name
- AL-SIGHT (NCT04328207)
- Testing
- No Financial Incentive, Financial Incentive
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Amblyopia
A Comparative Study Between Dissociative Treatment and Binocular Interactive Treatment in Amblyopia
Amblyopia is a unilateral or, infrequently, a bilateral reduction of best corrected visual acuity which cannot be attributed to coexisting eye or visual pathway disease.
- Trial name
- NCT03255707
- Testing
- eye patch, dichoptic treatment
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fungal Infection, Haematological Malignancy
Pharmacogenomics for Better Treatment of Fungal Infections Clinical Trial
This project aims to address invasive fungal infections in patients, by precision dosing of voriconazole based on CYP2C19 genotype testing with Bayesian dose-forecasting dosing software to develop patient-centric and maximally…
- Conditions
- Fungal Infection, Haematological Malignancy, Blood Cancer, Infectious Disease
- Trial name
- PRAGMATIC (NCT06510699)
- Testing
- genotype-directed dosing with dosing software based on therapeutic drug monitoring
- Where
- 7 sites in United States, Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Healthy
Effects of Single-dose and Steady-state TPV/r on the Steady-state Pharmacokinetics of Clarithromycin and a Preliminary Assessment of the Effects of a Standard High-fat Test Meal on the Steady-state Pharmacokinetics of Tipranavir
To determine the effects of single-dose and steady-state Tipranavir/Ritonavir (TPV/r) at 500 mg/200 mg bid on the steady-state pharmacokinetics of clarithromycin and to determine the effects of a standard high-fat test meal on…
- Trial name
- NCT02251769
- Testing
- Tipranavir, Ritonavir, Clarithromycin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
COVID-19
Efficacy and Safety of Direct Anti HCV Drugs in the Treatment of SARS-COV-2 (COVID-19)
COVID 19 which started from a zoonotic transmission related to crowded markets was confirmed to have a high potential for transmission to close contacts on 20 January 2020 by the National Health Commission of China and it was…
- Trial name
- CCOVID-19 (NCT04535869)
- Testing
- Sofosbuvir 400 MG plus Daclatasvir 200mg
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Immunization, HPV Infection
Comparing Immune Response of 2 vs 3 HPV Doses (27-45 Years Old)
The goal of this clinical trial is to compare a 2-dose and 3-dose series of 9vHPV vaccine among 27-45-year-old females to assess if 2 doses elicit a noninferior immune response.
- Conditions
- Immunization, HPV Infection, Human Papillomavirus
- Trial name
- NCT05672927
- Testing
- 9-valent HPV vaccine, 2 doses alternate timing, 9-valent HPV vaccine, 3 doses standard timing
- Where
- United States
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Mental Health Wellness 1
Mental Health Intervention for Black Fathers
The purpose of this study is to examine the feasibility of implementing a mental health intervention, using individual and group Cognitive Behavior Therapy (CBT), embedded into Fathers for a Lifetime; an existing parenting…
- Trial name
- NCT03552783
- Testing
- FFL + Cognitive Behavioral Therapy, Fathers for a Lifetime (FFL) only
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Caries,Dental, Pain
Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial
Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced…
- Conditions
- Caries,Dental, Pain, Plaque, Dental, Gingival Bleeding
- Trial name
- RCT (NCT06453005)
- Testing
- SMART Hall Technique or procedure
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- C K S Teja Institute Of Dental Sciences & Research
Amputation
Using a Psychosocial Transitional Group to Improve Adaptation, Coping and Mental Health Outcomes Following Limb Loss
People with limb loss receiving inpatient rehabilitation are at greater risk for depression and anxiety, social isolation, and generally have poor quality of life.
- Trial name
- NCT05082870
- Testing
- Supportive-expressive group therapy (SEGT)
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer
Preoperative Immunotherapy Combined With Stereotactic Radiation Therapy Boost in the Treatment of HER2-negative Breast Cancer
The goal of the study is to assess the safety and effectiveness of the combination of anti-PD1 immunotherapy (pembrolizumab) and radiotherapy in the preoperative treatment of HER2-negative breast cancer resistant to classical…
- Trial name
- BREAST-BOOSTER (NCT06472583)
- Testing
- Keytruda, Preoperative radiation therapy
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
HIV Infections
Effectiveness of an HIV Prevention Program That Targets the Inner Workings of High-risk Social Networks
This study will determine whether an HIV prevention program that targets the inner workings of social networks at high risk for HIV and other sexually transmitted diseases is effective in reducing frequency of high-risk sexual…
- Trial name
- NCT00705705
- Testing
- Network leader training, Standard HIV risk-reduction counseling
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Hypertrophic Skin Condition of Anterior Abdomen
Negative Pressure Wound Therapy-PICO: Cosmesis in Repeat C-Sections
There are millions of births each year with 32% of women undergoing cesarean sections (C-sections), which results in skin scarring. Repeat C-sections increased by 178% from 1979-2010.
- Trial name
- NCT05266053
- Testing
- PICO 7 dressing, Standard wound dressing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Large for Gestational Age (LGA), Pregnancy
Repeat Late GDM Testing and Cesarean Delivery Rates
The goal of this randomized trial is determine if re-testing for gestational diabetes in the third trimester after an ultrasound measurement of estimated fetal weight (EFW) or abdominal circumference greater than 90%ile decreases…
- Trial name
- NCT07708129
- Testing
- Glucose tolerance test and continuous glucose monitor
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Shauna F. Williams, MD
Cesarean Section
The Effect of Post Cesarean Section Protocol of Care on Early and Follow up Outcomes
The aim of the current study is to evaluate the effect of post cesarean section protocol of care on early and follow up outcomes.The criteria for inclusion were; mothers can read and write, primipara or multipara who was admitted…
- Trial name
- NCT05300750
- Testing
- Oral fluids, Chewing gum
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
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