Clinical trials: surgery and procedures, open to volunteers
Acute Ichemic Stroke
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
The ELATE study is a prospective, observational study designed to evaluate the clinical outcomes and safety profile of endovascular thrombectomy compared with best medical treatment alone in patients presenting with acute…
- Trial name
- ELATE (NCT07922317)
- Testing
- Endovascular treatment
- Where
- Vietnam
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- 115 People's Hospital
Lung Carcinoma
Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers
This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers.
- Trial name
- NCT07553819
- Testing
- Accelerometry, Aerobic Exercise, Biospecimen Collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Peripheral Blood Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation
The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation
Background: Blood cancers (such as leukemias or lymphomas) often do not respond to standard treatments. A transplant of blood stem cells from a healthy donor can help people with these cancers.
- Trial name
- NCT05436418
- Testing
- Melphalan, Sirolimus, Total Body Irradiation (TBI)
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Bladder Carcinoma, Breast Carcinoma
The Vanguard Study: Testing a New Way to Screen for Cancer
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial.
- Conditions
- Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma
- Trial name
- NCT06995898
- Testing
- Biospecimen Collection, Device Usage, Electronic Health Record Review
- Where
- 46 sites in United States
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Hematologic Test, Agranulocytosis
Hematological Safety of Dipyrone Versus Paracetamol After Dental Extractions
The goal of this clinical trial is to compare the safety of dipyrone and paracetamol when used for pain relief after dental extractions in adults.
- Conditions
- Hematologic Test, Agranulocytosis, Side Effects, Blood Pressure Monitoring
- Trial name
- NCT07918040
- Testing
- Dipyrone administration, Paracetamol (drug), blood sampling
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Matheus Furtado de Carvalho
Adenocarcinoma
PRIMER: Development of Daily Online Magnetic Resonance Imaging for Magnetic Resonance Image Guided Radiotherapy
In radiotherapy high-tech scans with x-rays (CT scans) are taken before and during treatment to locate the tumour and ensure the radiation is hitting the target.
- Trial name
- NCT02973828
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Seroma, Inguinal Hernias
Primary Sac Abandonment and Distal Sac Fixation vs Complete Sac Dissection for Inguinoscrotal Hernias
The goal of this clinical trial is to compare the effect of primary abandonment of the sac and distal sac fixation vs complete sac dissection in patients with inguinoscrotal hernias undergoing trans abdominal pre-peritoneal…
- Trial name
- NCT07918430
- Testing
- Primary abondonment of sac and distal sac fixation, complete sac dissection
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems.
- Conditions
- Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency, Immune System Diseases, Autoimmune Lymphoproliferative
- Trial name
- NCT02579967
- Testing
- Immunosuppression Only Conditioning -Closed with amendment L, Reduced Intensity Conditioning, Myeloablative Conditioning-Closed with amendment L
- Where
- 2 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Spinal Cord Injuries, Healthy
Reticulospinal Control of Movements
Accurate movement execution is a result of a complex interplay between various muscle groups whose activity is controlled by different areas of the central nervous system.
- Trial name
- NCT04967274
- Testing
- Startling acoustic stimulus
- Where
- Switzerland
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Carotid Web
Familial Form of Carotid Web: a Doppler Ultrasound Study
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
- Trial name
- Family-WEB (NCT06336083)
- Testing
- Doppler ultrasound
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Bimaxillary Protrusion, Class II Div 1 Malocclusion
Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study
The effectiveness of discision in accelerating orthodontic canine retraction will be evaluated during clear aligner therapy and during conventional fixed orthodontic appliances.
- Trial name
- NCT07920276
- Testing
- Discision
- Where
- 2 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Gingival Graft, Recession, Gingival
i-PRF-Based Bioactive Matrix vs. Connective Tissue Graft in the Treatment of Gingival Recessions
This study aims to evaluate the efficacy of a novel bioactive matrix, consisting of an equine collagen core soaked in i-PRF and wrapped in L-PRF, used in combination with a coronally advanced flap as an alternative to the…
- Conditions
- Gingival Graft, Recession, Gingival, Platelet Rich Fibrin
- Trial name
- NCT07918326
- Testing
- Coronally advanced flap and i-PRF based bioactive matrix, Coronally advanced flap and subepithelial connective tissue graft
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Trigeminal Neuralgia
Trigeminal Neuralgia Electrophysiology
The study intervention is to perform standard somatosensory evoked responses limited to the face during rhizotomy procedures of the gasserian ganglion (trigeminal ganglion) for the treatment of trigeminal neuralgia.
- Trial name
- NCT05269472
- Testing
- Trigeminal Electrophysiology
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 751 sites in United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Hopeless Tooth in Esthetic Zone, Loss of Soft and Hard Tissue Around Implant
Peri-implant Tissue Changes Using Dual Zone Concept With Connective Tissue Graft Versus Concentrated Growth Factor
Tooth extraction not only alters the bony architecture of the alveolar ridge, but it also has an impact on the surrounding soft tissues.
- Conditions
- Hopeless Tooth in Esthetic Zone, Loss of Soft and Hard Tissue Around Implant, Immediate Implant Placement
- Trial name
- NCT06728696
- Testing
- Immediate implant with with dual zone technique using concentrated growth factor graft., Immediate implant with dual zone technique using connective tissue graft.
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Local
Comparison of Digital Intraosseous and Manual Intraligamentary Anesthesia in Children
The aim of this study is to compare the effects of digital intraosseous anesthesia and manual intraligamentary anesthesia techniques on pain scores during the restorative treatment of permanent mandibular molars in pediatric…
- Trial name
- NCT07524569
- Testing
- Intraligamentary anaesthesia, Digital Intraosseous Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Hypoxemia, Eldery People
HFNC vs Conventional Oxygen During Gastrocolonoscopy in Elderly Patients
This study aims to compare high-flow nasal oxygen (HFNO) with conventional nasal cannula oxygen during sedation for combined upper and lower gastrointestinal endoscopy (gastroscopy and colonoscopy) in patients aged 75 years and…
- Conditions
- Hypoxemia, Eldery People, Endoscopy, Colonoscopy
- Trial name
- NCT07916298
- Testing
- HİGH FLOW NASAL CANNULA OXYGEN, NASAL CANNULA OXYGEN
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
- Conditions
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
- Trial name
- AA-IPRF-PDDG (NCT07916545)
- Testing
- Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF, Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nahda University
Accelerate Tooth Movement
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth: A Digital Software Evaluation (Comparative Clinical Study)
- Trial name
- LLLT- piezo (NCT07873853)
- Testing
- low level LAZER therapy., Retraction of Maxillary Anterior Teeth (en-mass) with conventional methods., Piezocision-assisted orthodontic retraction
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Lumbar Disc Herniation
Cortical Surface Functional Changes After Lever Positioning Manipulation for Lumbar Disc Herniation
Lever positioning manipulation (LPM) is used to treat pain associated with lumbar disc herniation (LDH), but treatment-associated changes in cortical functional organization remain unclear.
- Trial name
- NCT07914842
- Testing
- Lever Positioning Manipulation
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
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