Clinical trials: sponsored by Changhai Hospital
Health Adults
Sodium Bicarbonate Solution Enhances Lens Cleanliness in Magnetically Controlled Capsule Endoscopy
Magnetically controlled capsule endoscopy (MCE) is a noninvasive alternative to conventional gastroscopy with comparable diagnostic accuracy.
- Trial name
- NCT07877506
- Testing
- Sodium Bicarbonate Solution
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Crohn's Disease (CD), Ulcerative Colitis (UC)
Accurately Profiling the Changes and Functions of Key Microflora in the Whole Intestinal Microenvironment Based on the Visual Sampling Capsule Endoscopy in Patients With Inflammatory Bowel Disease
This is a prospective, single-center, observational cohort study that will enroll 250 participants: 50 with active Crohn's disease, 50 with Crohn's disease in remission, 50 with active ulcerative colitis, 50 with ulcerative…
- Trial name
- NCT07799506
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Cancer
Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification
This study will follow people with chronic pancreatitis, people with pancreatic cancer, and healthy volunteers. The goal is to better understand why some people with chronic pancreatitis may later develop pancreatic cancer.
- Trial name
- NCT07612566
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion
Polyp Pretreatment Device for SSL Diagnosis
Colorectal cancer (CRC) is the third most common malignancy globally. Sessile serrated lesions (SSLs) account for 15-30% of CRC via the serrated pathway.
- Trial name
- NCT07601230
- Testing
- Polyp Pretreatment Device
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
IBD (Inflammatory Bowel Disease), Colonoscopy
Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients
The primary objectives of this project are twofold. On the one hand, it aims to investigate the current status of bowel preparation protocols and their quality in IBD patients undergoing colonoscopy, particularly focusing on the…
- Conditions
- IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation
- Trial name
- NCT07335705
- Testing
- Standard Pre-colonoscopy Bowel Preparation Protocol
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Bowel Preparation for Colonoscopy
Efficacy of Low-residue Full Nutritive Formula Powder in Bowel Preparation for Colonoscopy
Previously, our team compared the effects of a low-residue full nutrition formula podwer (FNFP) combined with 3 liters of polyethylene glycol(PEG) solution and the self-prepared low-residue diet combined with 3 liters of PEG…
- Trial name
- NCT06514989
- Testing
- Low-residue full nutrition formula podwer, Self-prepared low-residue diet
- Where
- 27 sites in China
- Volunteers
- 757 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm
Artificial Intelligence-powered Low-Dose Computed Tomography for Screening of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with early diagnosis crucial for improving survival. Due to the absence of effective screening methods, most patients are diagnosed at advanced stages.
- Conditions
- Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, High-grade Pancreatic Intraepithelial Neoplasia, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- AI-LDCT-PC (NCT07117045)
- Testing
- Diagnostic Evaluation for Positive AI Findings
- Where
- 5 sites in China
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
AI-powered Early Detection for Pancreatic Cancer Via Non-contrast CT in Opportunistic Screening Cohort
Pancreatic ductal adenocarcinoma (PDAC) remains a therapeutic challenge with 5-year survival rates of 13%, primarily attributable to advanced-stage diagnosis (AJCC Stage III/IV in >80% of cases).
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Intraepithelial Neoplasias, Intraductal Papillary Mucinous Neoplasm
- Trial name
- AI-PANC (NCT06638866)
- Testing
- PDAC, Pancreatic precursor lesions
- Where
- 3 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colonoscopy, Colonoscopy: Bowel Preparation
Risk Factors for Inadequate Bowel Preparation Before Colonoscopy
The primary objectives of this study are twofold: Firstly, to investigate the current status of bowel preparation protocols and their quality across hospitals at various levels in China, particularly following the release of the…
- Trial name
- NCT06878378
- Testing
- Investigation of Factors Influencing Bowel Preparation Quality
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Esophageal Cancer, Gastric Cancer
Effect of Premedication With Pronase on Mucosal Cleanliness During EGD
Gastric cancer and esophageal cancer are common malignant tumors that threaten people's life and health. Esophagogastroduodenoscopy (EGD) is an important tool for screening upper gastrointestinal tumors, especially early tumors…
- Trial name
- NCT06713421
- Testing
- Dimethicone+Pronase, Dimethicone, with Postural Exercise
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Bowel Preparation for Colonoscopy
Efficacy, Safety and Tolerability of Magnesium Sulfate With Low-volume Polyethylene Glycol for Colonoscopy Cleansing
Magnesium salts such as magnesium citrate are often combined with polyethylene glycol to make the intestinal preparation before colonoscopy, which has shown high cleaning efficacy.
- Trial name
- NCT06728839
- Testing
- 1L PEG + 50g magnesium sulfate, 3L PEG, 4L PEG
- Volunteers
- 1,329 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Radiotherapy
Chemoradiotherapy After Surgery Versus Preoperative Chemoradiotherapy for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors
The purpose of this observational study is to understand the effect of different timing of chemoradiotherapy on overall survival in patients with stage II/III low- and medium-level rectal cancer with or without high-risk factors
- Trial name
- NCT06566222
- Testing
- chemoradiotherapy after surgery, High-risk Factors
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Bowel Preparation for Colonoscopy
Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy
The clinical purpose of this study was to investigate whether the adjuvant application of linaclotide in bowel preparation for colonoscopy could improve the quality of bowel preparation or reduce the dosage of laxatives.
- Trial name
- NCT05291325
- Testing
- 3L PEG + Linaclotide, 3L PEG, 2L PEG + Linaclotide
- Where
- China
- Volunteers
- 1,607 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Chronic Pancreatitis
Gastrointestinal Microflora and Serum Metabolomics in Patients With Pancreatic Cancer and Chronic Pancreatitis
The investigators plan to collect throat swabs, saliva, feces and serum samples from pancreatic cancer patients, chronic pancreatitis patients and healthy people and clarify the characteristics of oral flora and serum metabolome…
- Trial name
- NCT06411470
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colonoscopy: Bowel Preparation
Efficacy of Short Time Intervals in Split-Dose Bowel Preparation of Oral Sulfate Solution for Colonoscopy
To evaluate whether oral sulfate solution administered in a short time interval (6-8 hours) between the first and last dose of laxative is not inferior to a long time interval (10-12 hours) in bowel preparation quality.
- Trial name
- NCT06317597
- Testing
- Magnesium Sulfate，Sodium Sulfate and Potassium Sulfate Concentrate Oral Solution
- Where
- China
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Apathy, Minor Stroke
Non-disabling Ischemic Cerebrovascular Event With Apathy
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. However, few previous studies have focused on affective impairment after transient ischemic attack (TIA) and minor stroke.
- Conditions
- Apathy, Minor Stroke, Transient Ischemic Attack, Stroke
- Trial name
- NCT04917237
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic HBV Infection, Drug Withdrawal
Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients
The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear.
- Trial name
- NCT06029634
- Testing
- T-bet B cell
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Capsule Endoscopy
MCE-new for Detection of Gastric Lesions
Clinical application of magnetically controlled capsule endoscopy : a prospective self-controlled trial
- Trial name
- NCT06020859
- Testing
- undergo NaviEC-2000Pro Gastro Scan mode, NaviEC-2000Pro Routine gastric examination, NaviEC-1000 Routine gastric examination
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital