Clinical trials: sponsored by Indiana University
Healthy
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels
The vagus or vagal nerve is a nerve that sends signals from the brain to other parts of the body to control involuntary functionm, including stomach function, and it is important to the regulation of insulin, C-peptide, and…
- Trial name
- TaVNS (NCT06597149)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
CBD, Transplant Complication
Drug-gene-nutraceutical Interactions of Cannabidiol and Tacrolimus
The information learned in these studies will help to inform doctors as to how to appropriately adjust doses of cannabidiol and tacrolimus in order to improve health outcomes and long-term treatment success for transplant…
- Conditions
- CBD, Transplant Complication, Kidney Disease, Chronic
- Trial name
- NCT05490511
- Testing
- Tacrolimus single dose, Epidiolex single dose, Epidiolex steady-state and tacrolimus single dose
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Indiana University
Caries, Erosive Tooth Wear
New In Situ Model Design for Caries and Erosion
This study will test simultaneously and independently two novel in situ models, one for caries and one for erosive tooth wear (ETW), based on the simulation of these dental conditions on enamel specimens placed on 3D-printed…
- Trial name
- NCT07849270
- Testing
- 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Methods for Addiction Treatment
This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape.
- Trial name
- NCT07210268
- Testing
- TI-NDBS
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Lung Cancer
Increasing Equity in Lung Cancer Screening
The overall objective of this mixed methods study is to: 1) Refine the Emergency Department Lung Cancer Screening (ED-LCS) intervention using qualitative interviews among key stakeholders; 2) pilot test the ED-LCS intervention…
- Trial name
- LUCARE (NCT06360822)
- Testing
- ED-LCS
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Indiana University
Urologic Diseases
Patient Satisfaction of Virtual vs In-Person Workup and Treatment of Lower Urinary Tract Symptoms.
This study is being done to compare usefulness of data collected in uroflowmetry, a test that measures the amount of urine released from the body, at home versus in the doctor's office.
- Trial name
- NCT05508165
- Testing
- Stream Dx, DFree, TestCard
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
Normal Esophageal Distensibility
Measuring Normal Esophageal Flexibility in Children Using EndoFLIP
This study will measure normal esophageal flexibility (distensibility) in children using the Endoluminal Functional Lumen Imaging Probe (EndoFLIP).
- Trial name
- EndoFLIP (NCT07754695)
- Testing
- Endoluminal Functional Lumen Imaging Probe (EndoFLIP)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alzheimer Disease, Late Onset Alzheimer Disease
Alzheimer's Disease Genetics Study
The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD).
- Conditions
- Alzheimer Disease, Late Onset Alzheimer Disease, Dementia
- Trial name
- NCRAD (NCT00064870)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Malaria, Asymptomatic Malaria
OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan Schoolchildren
Malaria remains a major cause of illness among school-aged children in sub-Saharan Africa, many of whom carry asymptomatic Plasmodium falciparum infections that may contribute to anemia, inflammation, school absenteeism, and…
- Conditions
- Malaria, Asymptomatic Malaria, Intermittent Preventive Treatment
- Trial name
- Optimal LEAP (NCT07798583)
- Testing
- Monthly DP, Quarterly DP
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Basic Science
Factors Affecting Sensory and Motor Learning
How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to…
- Trial name
- NCT05374460
- Testing
- Explanatory diagram, Direct vision, Movement feedback, target hand
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Indiana University
Skull Base Neoplasms, Cerebrospinal Fluid Leakage
Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery
The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the nasoseptal flap harvest site during endoscopic…
- Conditions
- Skull Base Neoplasms, Cerebrospinal Fluid Leakage, Nasal; Hypertrophy, Mucous Membrane (Septum)
- Trial name
- NCT05898074
- Testing
- Non-Absorbable Packing (Silastic Splint), PuraGel (RADA16) Hydrogel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gestational Diabetes, Pregnancy Complications
Lifestyle Interventions to Improve Glycemic Parameters and Reduce Gestational Diabetes in High-risk Pregnant Individuals
The goal of this study is assess the impact of a higher intensity dietary and activity counseling program to improve blood sugar control and reduce the chance of developing gestational diabetes (GDM) as compared to the current…
- Trial name
- NCT06445270
- Testing
- GDM Prevention Program
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Glaucoma
Smart Soft Contact Lenses for Monitoring Glaucoma
This study is exploring the effectiveness and safety of soft contact lenses with embedded sensors, called smart contact lenses. Smart contact lenses are used to measure the pressure inside the eye.
- Trial name
- NCT07224542
- Testing
- Bare Contact Lens, Experimental Smart Contact Lens, Commercially available smart contact lens
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Immobility Syndrome, Deep Venous Thrombosis
Bedside Bike Early Mobilization Program for Inpatients
Hospital immobility leads to serious complications including muscle loss, weakness, delirium, pressure ulcers, and blood clots. Despite being medically stable, hospitalized patients spend over 90% of their time in bed due to…
- Conditions
- Immobility Syndrome, Deep Venous Thrombosis, Delirium, Hospital Acquired Condition
- Trial name
- BB-STEP (NCT07281638)
- Testing
- Bedside Bike
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Diplopia, Monocular
VisionApp - Ghosting
Recent Android mobile device technology is available which allows user-measured refractive error and reading add power. This technology could be quite useful to the clinical and research community.
- Trial name
- NCT07571538
- Testing
- Proclear 1 Day Contact Lens, MyDay Contact Lens, NaturalVue Contact Lens
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV/AIDS, Pregnancy Related
Measuring Adverse Pregnancy and Newborn Congenital Outcomes
The purpose of this study is to develop a pharmacovigilance (PV) surveillance program to monitor adverse pregnancy and infant outcomes, including the presence of congenital abnormalities, among HIV-positive and HIV-negative women…
- Conditions
- HIV/AIDS, Pregnancy Related, Congenital Disorders, Newborn Morbidity
- Trial name
- MANGO (NCT04405700)
- Testing
- Pharmacovigilance surveillance program
- Where
- Kenya
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Drug-Drug Interaction
Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK
The main goal of this clinical study is to test how CYP2B6 genetic variations and efavirenz (cornerstone in HIV-1 therapy) dictate the disposition (PK) of CYP2B6 substrate (methadone) and PK and effect (PD) of CYP1A2 substrate…
- Trial name
- NCT05789173
- Testing
- Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
Satiety
A Comparison of Satiety Effects Two Commercially Available Snack Bars
The researchers are investigating the satiety effects of two commercially available snack bars. Qualified participants are age 18-65 with a body mass index of 18.5 to 29.9 kilograms of body weight per meter squared in height who…
- Trial name
- NCT07227701
- Testing
- High carbohydrate snack bar, High protein snack bar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gait, Balance
Sensor Ankle Brace for Special Operations Rehabilitation - Phase 1
The primary purpose of this study overall is to validate a modified version of a commercially available ankle brace. Inertial measurement unit sensors incorporated into an existing ankle brace ("sXAB") by TayCo Brace, Inc.
- Conditions
- Gait, Balance, Biomechanical Data, Postural Control
- Trial name
- NCT07085416
- Testing
- Sensor-enabled Athletic X Ankle Brace (sXAB)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Indiana University
Minimalist Footwear, Traditional Foot Exercise Program
Foot Strengthening to Improve Balance and Gait in Older Adults
The goal of this clinical trial is to learn whether different foot-strengthening strategies can improve foot strength, balance, walking ability, and fall-related outcomes in middle-aged and older adults (ages 45-85 years).
- Conditions
- Minimalist Footwear, Traditional Foot Exercise Program, Foot Strengthening Device (ToePro), Control Condition
- Trial name
- NCT07384754
- Testing
- Minimalist footwear, Foot strengthening exercises, ToePro foot strengthening device
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University