Clinical trials: sponsored by McMaster University
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetic Macular Edema
Mean Visual Acuity Changes Following Five Injections of Aflibercept
Diabetic Macular Edema is a serious ocular consequence of poorly controlled diabetes. Even though significant research has been done to clarify the pathogenesis of DME, a clear causal pathway of the complication is of yet…
- Trial name
- NCT02645266
- Testing
- Aflibercept Injection [Eylea]
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Disease, Aging
Compassionate Communities Neighbourhood Program
This study will evaluate a Compassionate Communities-based intervention aimed at reducing social isolation by mobilizing individuals to act on their health and social needs individually, and in collaboration with fellow members…
- Trial name
- WECCC-NHB (NCT03634163)
- Testing
- Neighbourhood exchange, Quality of Life Assessment
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Female, Premenopausal
The Influence of Plan B® on Cardiovascular Health.
The goal of this double-blind randomized controlled trial is to learn about the impacts of a single dose of Plan B® on the cardiovascular system in young, health, premenopausal females.
- Trial name
- LEVOH (NCT07759635)
- Testing
- Plan B (Levonorgestrel)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sacro-iliac Joint Pain
Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain
This study will contribute to the current literature that have compared joint injections with steroid versus ketorolac providing evidence for the use of ketorolac for SI joint pain.
- Trial name
- NCT06081101
- Testing
- Methylprednisolone Injection, Ketorolac Injection
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Inflammatory Bowel Disease
Investigating Serotonin Signalling in IBD Patients
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- IBD (NCT01650311)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cognition, Sodium Bicarbonate
Exercise-Induced Lactate and Cognitive Function (ExLBC)
A single bout of exercise can rapidly improve cognitive functions including memory, attention, and executive functions, which help us navigate through everyday life.
- Conditions
- Cognition, Sodium Bicarbonate, Lactate, Exercise
- Trial name
- NCT06817681
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- 2 sites in Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Femoroacetabular Impingement
Prospective Evaluation of Sport Activity and the Development of Femoroacetabular Impingement in the Adolescent Hip
Femoroacetabular impingement (FAI) is a condition of the hip where there is a mis-fit between the femoral head (ball) and hip acetabulum (socket).
- Trial name
- PREVIEW (NCT03891563)
- Where
- 4 sites in Canada, Netherlands and 1 more
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- McMaster University
Guideline Development
Wording Approaches to Convey the Strength of Recommendations in Health Guidelines
Recommendations from health organizations rest on a scale. On this scale, some recommendations can be "stronger" than others. This "strength" should be easily understood by everyone, including members in the public and healthcare…
- Trial name
- (SOR) (NCT07854548)
- Testing
- GRADE approach ("recommends" and "suggest"), New approach ("strongly recommends" and "conditionally recommends"), Alternate approach ("should" and "may")
- Where
- Canada
- Volunteers
- 741 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Chronic Cough (CC)
- Trial name
- CANMuc (NCT06858748)
- Testing
- Observational
- Where
- 7 sites in Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- McMaster University
Knee Osteoarthritis
Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis
People with knee arthritis often experience constant pain, and current treatments aren't very effective. This can lead to limited movement and more health problems.
- Trial name
- NCT06228573
- Testing
- Yoga
- Where
- 3 sites in Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression, Postpartum Anxiety
Online 1-Day CBT-Based Workshops for Preventing Postpartum Depression
To conduct a randomized controlled trial (N=408) examining the impact of an online cognitive behavioural therapy (CBT)-based workshop on rates of postpartum depression (i.e., EPDS scores at 2-months postpartum) when added to…
- Trial name
- NCT05753176
- Testing
- Online 1-Day Cognitive Behavioural Therapy-Based Workshop
- Where
- Canada
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- McMaster University
Monkeypox
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
- Trial name
- SMART (NCT05745987)
- Testing
- Bavarian Nordic smallpox vaccine, Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- 10 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Influenza (Healthy Volunteers)
SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial)
The flu is a health risk for Canadians. It causes up to 15,000 hospitalizations every year and is one of the top 10 causes of death. Getting a flu vaccine is the best way to prevent the flu and any severe complications.
- Trial name
- SAFE (NCT07739719)
- Testing
- LAIV FLUMIST
- Where
- Canada
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- McMaster University
Creativity
The Creative Team Member: A Study of the Influence of AI Integration Timing on Brainstorming and Ideation
This study aims to examine how the timing of artificial intelligence (AI) integration during group brainstorming activities affects the creativity and ideation of participants.
- Trial name
- NCT07693803
- Testing
- Artificial Intelligence First (Early Integration), Artificial Intelligence Last (Late Integration)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Syphilis
The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care
The goal of this clinical trial is to learn if a finger-prick blood test for rapid diagnosis of syphilis infection can be implemented in a low-barrier prenatal clinic for people at risk of syphilis in pregnancy.
- Trial name
- PRESSING (NCT06829602)
- Testing
- Rapid Syphilis/HIV point-of-care test
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mobility Limitation
Stepping-Up: Partnering With the Community to Prevent Early Mobility Decline
Preclinical mobility limitations (PCML) manifest early in the process of declining mobility, and are not typically identified or acted upon by clinicians.
- Trial name
- Stepping-Up (NCT04368949)
- Testing
- Stepping-Up, Telephone-Based Coaching Walking Program, Chair-Based Yoga Program
- Where
- Canada
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- McMaster University
Endometriosis (Diagnosis), Endometriosis
Combining Ultrasound and Biomarkers to Diagnose Superficial Endometriosis
Endometriosis is a benign gynecological disease characterized by uterine-like cells growing outside the uterus, leading to pain, infertility, and inflammation.
- Trial name
- SPGENDO (NCT05523284)
- Testing
- SonoPODography
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University