Clinical trials: sponsored by Western University, Canada
Asthma; Eosinophilic
REverse LuNg Airway and Vascular RemOdeling in Asthma ReMission (ReNORM)
In this program of research, the investigators aim to answer the question: In patients with asthma aged 18-80, how do the lung airways and vessels respond to biologic therapy and what role does age and asthma duration have in…
- Trial name
- ReNORM (NCT07174713)
- Testing
- Biologic Therapy
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Functional Movement Disorder
Action Outcome Latencies as a Measure of Sense of Agency in Functional Movement Disorders.
Functional movement disorders (FMD) are among the most common neurological conditions seen in clinical practice, yet they are poorly understood and often misdiagnosed.
- Trial name
- NCT07302308
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cannabis Use, Cannabis Smoking
Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic…
- Conditions
- Cannabis Use, Cannabis Smoking, Marijuana Smoking, Marijuana Usage
- Trial name
- NCT03909477
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFTs)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
E Cigarette Use
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with…
- Trial name
- NCT04616313
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy Volunteers
Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study
Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
- Trial name
- NCT03169673
- Testing
- Hyperpolarized Helium 3 Magnetic Resonance Imaging
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy
Longitudinal 3He Magnetic Resonance Imaging of Healthy Lung
Healthy elderly subjects male and female aged 65-85 will undergo MRI, lung function and exercise testing for the development of tools to quantify and validate longitudinal in vivo magnetic resonance imaging phenotypes of the…
- Trial name
- NCT02483403
- Testing
- Hyperpolarized Helium-3, MRI
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Health Behavior
Machine-based Algorithm for Increased Physical Activity and Sustained User Engagement
A cohort analytic study (i.e., observational study following a cohort over time to compare outcomes between those exposed and unexposed to an intervention) was conducted over a 17-week period (March 7, 2022 to June 30, 2022).
- Trial name
- NCT06388317
- Testing
- Adaptive Step Goal (Intervention), Static Step Goal (Control)
- Where
- Canada
- Volunteers
- 1,249 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Older Adults, Driving
Tech-wise Driver (Technology Acceptance of Targeted ADAS for Older Adults)
The tech-wise driver: Exploring the sustained efficacy and technology acceptance of targeted ADAS for older drivers A significant percentage of road traffic fatalities registered in Canada occurred among older adults.
- Conditions
- Older Adults, Driving, Simulator
- Trial name
- NCT06437665
- Testing
- The intervention name in this study is ADAS-integrated driver simulation training.
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Functional Movement Disorder
Study of Sensory Attenuation in Functional Movement Disorders
Functional movement disorders (FMD) are conditions where people experience unusual movements or difficulties with walking, not caused by a specific brain or nerve injury but related to how the brain controls movements.
- Trial name
- NCT06872788
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Movement Disorders
Handwriting Analysis in Movement Disorders.
Movement disorders are a group of neurological conditions that cause problems with movement, either in the form of excessive, reduced, or slow movements.
- Trial name
- NCT06436287
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Functional Movement Disorder
Passive Thoughts in Functional Movement Disorders
Passive thoughts also known as mind-wandering are the thoughts that are not produced from the current task. When we aren't focused on a task that needs our full attention, our minds tend to drift from one thought to another.
- Trial name
- NCT06439017
- Testing
- Questionaire
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Physical Inactivity, Healthy Eating
An Incentive-based mHealth Application for Physical Activity
This 12-week single-arm pilot study in the UK evaluated an incentive-based mobile health (mHealth) physical activity (PA) intervention using the ORBIT model.
- Trial name
- NCT05294692
- Testing
- Financial Health Incentives
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Disorders of Consciousness, Psychedelic Experiences
The Effects of Psilocybin on Shared Experience in Film Processing
The goal of this clinical trial is to learn whether certain methods of detecting awareness in vegetative or minimally conscious patients (using neuroimaging) are sensitive to the effects of psilocybin (a psychedelic drug).
- Trial name
- NCT06529939
- Testing
- Psilocybin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Behavior, Drinking, Alcohol Drinking
Effectiveness of a PMT Intervention to Reduce Alcohol in Young Adults
This study will examine the effectiveness of a 7-minute informational video using the threat and coping components of the Protection Motivation Theory (PMT) reduces alcohol intention and behaviour among young Canadian adults.
- Conditions
- Behavior, Drinking, Alcohol Drinking, Colorectal Cancer Control and Prevention, Healthy Volunteers
- Trial name
- NCT06615648
- Testing
- PMT, Non-contact Control
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Breastfeeding, Pain
Women Empowered Through Education to Breastfeed
The experience of breastfeeding-related pain is common for postpartum women, but is not often anticipated as part of the postpartum experience.
- Conditions
- Breastfeeding, Pain, Nipple Pain During Lactation
- Trial name
- NCT03481166
- Testing
- Education on breastfeeding pain
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Stigma, Social, Weight, Body
Psychobiological Processes in Social Evaluation
Higher-weight individuals face pervasive weight-related stigma and discrimination in their daily lives. There is conceptual and empirical evidence to suggest that weight stigma contributes to worse physical and psychological…
- Conditions
- Stigma, Social, Weight, Body, Compassion, Stress Reaction
- Trial name
- NCT05107609
- Testing
- Acute Self-Compassion Intervention
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Intimate Partner Violence
IHEAL Trial: Effectiveness of a Health Promotion Intervention for Women Who Have Experienced Intimate Partner Violence
Living with an abusive partner has many negative impacts on women's health, safety and the quality of their lives. These issues often continue when women separate, or take steps to separate, from an abusive partner, and can make…
- Trial name
- NCT03573778
- Testing
- iHEAL, Information about Community Services
- Where
- 3 sites in Canada
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cognitive Change
Assessing the Effects of the Muse Meditation System on Cognition and Well-being
Interaxon markets a head-worn EEG biofeedback device ('Muse') to encourage and aid effective meditation and sleep. This device has been previously shown to improve workplace wellness, fatigue and quality of life, and performance…
- Trial name
- MuseCog (NCT04790929)
- Testing
- Muse, Meditation Coaching
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Mediation, Coaching
Assessing the Effects of the Muse Sleep Intervention on Sleep
In this study, we will examine whether use of the Sleep Intervention protocol marketed by Interaxon (the 'Muse'), leads to improvements in sleep quality (e.g.
- Trial name
- MuseSleep (NCT04863690)
- Testing
- Meditation, Digital Coaching, Digital Coaching plus Human Coaching
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Physical Inactivity, Healthy Eating
Examining Engagement Predictors of Health and Fitness App Uptake and Subscription in the General Population
This will be a 24-week prospective study that will incorporate user base data of WayBetter Inc.'s app, "WayBetter," to examine user mHealth app engagement.
- Conditions
- Physical Inactivity, Healthy Eating, Mental Health Wellness 1
- Trial name
- NCT06023342
- Where
- Canada
- Volunteers
- 1,084 people, healthy volunteers welcome
- Sponsor
- Western University, Canada