Clinical trials: enrolling by invitation
Eccentric Cycling Exercise Training
Effectiveness of Eccentric Cycling Exercise in Ambulatory Rehabilitation for Patients With Cardiopulmonary Diseases: A Pragmatic Randomized Controlled Trial
In eccentric cycling exercise (ECC), the cyclist must oppose backwards moving pedals on a specialized motor-driven ergometer. Throughout this process, the force applied on the pedals exceeds the torque generated by the…
- Trial name
- NCT07815366
- Testing
- Eccentric cycling exercise
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Aphasia
First Responder Aphasia Strategy Training
This study aims to determine the impact of a collaborative approach to training law enforcement officers and first responders about aphasia including their knowledge and confidence in communicating with individuals with aphasia…
- Trial name
- NCT06678854
- Testing
- Training about Aphasia
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes, Cardiovascular Disease
Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations
Background: African Americans have one of the highest rates of type 2 diabetes in the United States, and often have other medical problems related to obesity and cardiovascular disease.
- Trial name
- NCT01316783
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Peri-Implantitis
Intaglio Surface of Full-arch Implant Supported Prosthesis
The purpose of the study is to determine if there is an association between the intaglio shape of full-arch implant-supported prosthesis and marginal bone level around implants.
- Trial name
- NCT06636097
- Testing
- Full arch
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Virus Infection, RNA
Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange
This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and…
- Trial name
- GenX (NCT05534425)
- Testing
- GenX intergenerational mentoring program
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Development and Testing of a Sports Intervention to Promote Physical Activity in Rural Girls
The goal of this study is to examine the impact of a 12-week sports sampling and physical literacy program on rural girls' physical activity.
- Trial name
- GirlsPLAY (NCT06229457)
- Testing
- Girls PLAY program
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Longitudinal Studies, Prospective Studies
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
TH-CLINICAL-TIME is a prospective, longitudinal observational study evaluating how changes in clinical measurements over time may help researchers better understand patient health trajectories and clinically meaningful outcomes.
- Conditions
- Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
- Trial name
- CLIN-TIME (NCT07812831)
- Testing
- No Study-Assigned Intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Dental Etching, Dental Bonding
Comparison of Orthodontic Bracket Bond Failure Using Acid Etching With or Without Sandblasting
The goal of this clinical trial is to assess if sandblasting before acid etching reduce orthodontic bracket bond failure in fixed orthodontic treatment.
- Conditions
- Dental Etching, Dental Bonding, Acid Etching, Acid Etching, Dental
- Trial name
- AE SBE BF BB (NCT07617480)
- Testing
- Sandblasting with acid etching vs Acid etching alone, Acid Etching only
- Where
- Bangladesh
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tanzila Rafique
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Limb Length Discrepancy
Ultrasound Use to Measure Magnetically Controlled Growing Rods
The goal of this clinical trial is to learn if an ultrasound can measure the length of an internal tibia and femur lengthening rod.
- Trial name
- NCT07212049
- Testing
- ultrasound measurement, X-ray imaging of tibia and/or femur
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Electronic Health Records
The Role of Framing and Choice Architecture in Patients' Reactions and EHR Error Discovery and Reporting
The first goal of our research is to understand the effects of different wordings of certain messages on patients' engagement in reviewing their electronic health records (EHRs).
- Trial name
- NCT07206550
- Testing
- Framing
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Beta Alanine Supplementation, Placebo - Control
Beta-Alanine Effects on Neuromuscular and Cardiovascular Performance in Female Rugby Players
This study will examine the effects of beta-alanine supplementation on physical performance in female rugby players, who will ingest 4.8 grams/day over a four-week period.
- Trial name
- BA_RUGBY (NCT07809321)
- Testing
- Beta-Alanine
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Malocclusion, Canine Retraction
Maxillary Canine Retraction Using Stainless Steel and Titanium-molybdenum Alloy Wires in TAD-supported Segmental Mechanics
The goal of this randomized clinical study is to compare the effectiveness of stainless steel (SS) and titanium-molybdenum alloy (TMA) wires for maxillary canine retraction using TAD-supported segmental mechanics.
- Conditions
- Malocclusion, Canine Retraction, Orthodontics, Tooth Movement Techniques
- Trial name
- NCT07645417
- Testing
- A titanium-molybdenum alloy reverse-closing loop, A stainless steel reverse closing loop
- Where
- Bangladesh
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tanzila Rafique
Overweight Adults
Effects of a Sugar-Based Synbiotic Product on Cardiometabolic and Intestinal Health (SUGAR-SYN BC3O)
This randomized, double-blind, controlled, crossover study investigates the effects of a sugar-based synbiotic product containing inulin and Bacillus coagulans BC30™ spores in healthy overweight individuals.
- Trial name
- SUGAR-SYN BC3O (NCT07806383)
- Testing
- Sugar-Based Synbiotic Product, Inulin-Containing Sugar Product
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Post Operative Delerium, Post Operative Cognitive Dysfunction
Eye Movements to Predict Post-Operative Delirium
Postoperative delirium (POD) is a common complication in older adults undergoing surgery, lacking objective and noninvasive diagnostic methods.
- Trial name
- EYE-POD (NCT07806487)
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Intrathecal Dexmedetomidine
This Study Aims to Determine Whether Lower Doses (4 µg) of Intrathecal Dexmedetomidine Can Provide Comparable Analgesic Benefits While Minimizing Adverse Hemodynamic Effects in Patients Encountered in Our Setup( Shifa International Hospital Islamabad).
This study aims to determine whether lower doses (4 µg) of intrathecal dexmedetomidine can provide comparable analgesic benefits while minimizing adverse hemodynamic effects in patients encountered in our setup( Shifa…
- Trial name
- NCT07807020
- Testing
- Intrathecal Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shifa International Hospital
IUD Insertion Pain
Oral Ketorolac for IUD Pain Reduction
To determine if oral ketorolac given at different timepoints prior to intrauterine device (IUD) insertion influences pain experienced during this procedure.
- Trial name
- NCT06853327
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill