Clinical trials: sponsored by University of Colorado, Denver
Post Traumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Women With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular and renal function in premenopausal women with PTSD-related nightmares, and examine whether these improvements…
- Conditions
- Post Traumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT07021014
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Inactivity, Overweight and Obesity
A Pilot Factorial Trial of an Integrated Lifestyle Intervention
This study plans to learn more about the feasibility and acceptability of integrating the Move physical activity support program within an existing lifestyle intervention program.
- Trial name
- NCT06116435
- Testing
- Prevent T2, Move group-based classes, Fitness Membership
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Substance Use Behavior, Cannabis Intoxication
Substance Use and Media Preferences
The goal of this randomized clinical trial is to learn how alcohol use, cannabis use, and using both substances affect whether and how quickly people stop a video being shown to a woman.
- Conditions
- Substance Use Behavior, Cannabis Intoxication, Alcohol Intoxication
- Trial name
- NCT07922239
- Testing
- Alcohol beverage, Cannabis (smoked flower), Simultaneous Alcohol and Cannabis
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Menopause Hot Flashes
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce…
- Conditions
- Menopause, Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular
- Trial name
- NCT06975111
- Testing
- Metformin, semaglutide, Anti-hypertensives
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Primary Care Patients, Primary Care Center
Testing the Impact of the MOHR Follow-up Support
This study will evaluate the impact of 3 different strategies to increase engagement of participants in My Own Health Report (MOHR) and health behavior change activities over time.
- Trial name
- NCT07569224
- Testing
- Providing reminder and resources via messages, Reminder and resources sent via navigation, Regular care
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Communication Barriers
Examining the Impact of a Patient Communication Pathway in the Critical Care Setting on Patient Experience and Nursing Staff's Perceptions of Usability
The purpose of this study is to assess how an evidence-based communication protocol combined with Vidatalk can impact patient ICU experience and how usable this approach is perceived by nursing staff.
- Trial name
- NCT07897877
- Testing
- Evidence-based communication protocol associated low and high-tech communication approaches (i.e. Vidatalk)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Diabetes Mellitus
Multicenter Assessment of the Pancreas in Type 1 Diabetes
The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using advanced, quantitative…
- Trial name
- MAP-T1D (NCT03585153)
- Testing
- Non-contrast magnetic resonance imaging
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Periodontal Diseases
Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Hypothesis: There will be an additional reduction of pocket depth and gain of clinical attachment when dehydrated human amnion-chorion membrane (dHACM) is placed into the periodontal disease defect after mechanical scaling and…
- Trial name
- NCT03836378
- Testing
- BioXclude™
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hydrogen Sulfide, Gastrointestinal Microbiome
Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production
The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production.
- Trial name
- NCT06802276
- Testing
- High Cysteine Diet, Low Cysteine Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cancer
Cancer Prevention for Young Rural Adults
Young adults aged 18-26 engage in a number of behaviors that increase their risk of developing cancer later in life including sedentary lifestyles, unhealthy eating, nicotine produce us, heavy drinking of alcohol, increased UV…
- Trial name
- NCT05618158
- Testing
- 4 Corners Rural Health Cancer Prevention
- Where
- 5 sites in United States
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Infertility, Obesity
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype.
- Conditions
- Infertility, Obesity, Diminished Ovarian Reserve (DOR), Diminished Ovarian Reserve
- Trial name
- NCT06414096
- Testing
- Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
- Trial name
- NCT05107908
- Testing
- Active Implicit Priming, Control Implicit Priming, Food Exposure Task
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder
Preliminary Efficacy of Occupational Therapy Integrating Horses on Self-regulation in Youth With Autism
The goal of this clinical trial is to learn about occupational therapy integrating horses for autistic youth. The main questions it aims to answer are: Does occupational therapy integrating horses improve self-regulation in…
- Trial name
- NCT05846932
- Testing
- OTEE HORS, OT Clinic
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Medication Abuse, Harm Reduction
Clinical Decision Support to Improve System Naloxone Co-prescribing
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert to facilitate the co-prescribing of naloxone, an opioid overdose reversal agent, with high-risk opioid prescriptions.
- Conditions
- Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
- Trial name
- NCT06271668
- Testing
- Naloxone Co-prescribing Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 114,272 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Medication Abuse, Harm Reduction
Clinical Decision Support for Safety of Opioid Transitions
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert designed to notify providers when an opioid prescription will result in a patient transitioning into a new phase of opioid therapy.
- Trial name
- NCT06527040
- Testing
- Opioid Transitions Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver