Clinical trials: CPAP, completed
Obstructive Sleep Apnea Syndrome
Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure
Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea syndrome (OSAS). Two positive airway pressure (PAP) modalities can be used: Fixed pressure, in which the effective…
- Trial name
- AgirSASadom (NCT01090297)
- Testing
- S8 Spirit 2, Somnosmart 2, Remstar Auto
- Where
- France
- Volunteers
- 322 people
- Sponsor
- AGIR à Dom
Respiratory Distress Syndrome, Newborn
The Use of Heliox Via Nasal CPAP to Prevent Early CPAP Failure in Premature Infants: A Feasibility Study
The purpose of this study is to evaluate the safety and utility of using heliox gas in combination with nasal CPAP in premature infants.
- Trial name
- NCT00739115
- Testing
- Heliox gas
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hawaii Pacific Health
Hypertension,Essential, Obstructive Sleep Apnea
A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling
The objective of this proposal is to evaluate whether mandibular advancement device (MAD) is non-inferior to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA) and blood pressure…
- Trial name
- CRESCENT (NCT04119999)
- Testing
- Mandibular Advancement Device, Continuous Positive Airway Pressure
- Where
- Singapore
- Volunteers
- 321 people
- Sponsor
- National University of Singapore
Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
Electrical impedance tomography (EIT) is non-invasive and provides functional imaging of the lung and it could be a useful tool to diagnose chronic lung allograft dysfunction (CLAD) and specially Bronchiolitis Obliterans Syndrome…
- Conditions
- Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction, Bronchiolitis Obliterans Syndrome
- Trial name
- CLAD (NCT02863835)
- Testing
- EIT, Salbutamol nebulisation and with CPAP
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Distress Syndrome in Premature Infant, Surfactant
Clinical RD (Respiratory Distress) Score for Objective Decision Making for Surfactant Therapy
To develop a comprehensive 'Clinical RD score' for decision making for administration of Surfactant in respiratory distress syndrome in preterm infants with gestation of 26 0/7 - 34 6/7 weeks and to assess the validity of this…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Surfactant, CPAP
- Trial name
- NCT03273764
- Where
- India
- Volunteers
- 209 people
- Sponsor
- Lady Hardinge Medical College
Cardiogenic Pulmonary Edema
Helmet CPAP Versus HFNC in Acute Cardiogenic Pulmonary Edema
This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Oedema (ACPE) patients in the Emergency Department (ED) delivered by Helmet CPAP (hCPAP) and…
- Trial name
- HCPAPvsHFNC (NCT04005092)
- Testing
- hCPAP versus HFNC
- Where
- Malaysia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Hospital Raja Permaisuri Bainun
Sleep Disorder; Breathing-Related, Pain
Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids
Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB).
- Conditions
- Sleep Disorder; Breathing-Related, Pain, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- PRESTO (NCT04928157)
- Testing
- Positive Airway Pressure (PAP)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Analysis of a New Mask for Positive Airway Pressure (PAP) Device Users
BACKGROUND AND AIMS Continuous positive airway pressure (CPAP) is an effective therapy to treat sleep apnea. Sleep apnea is a condition where the airways collapse when the patient is asleep.
- Trial name
- NCT01847846
- Testing
- CPAP mask - prototype
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- ResMed
Sars-CoV2
The Prone Position in Covid-19 Affected Patients
The prone position during mechanical ventilation in patients with Acute Respiratory Distress Syndrome (ARDS) is able to improve oxygenation and thus reduce mortality.
- Trial name
- PRON-COVID (NCT04365959)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milano Bicocca
Acute Respiratory Failure
High Flow Nasal Cannula With Noninvasive Ventilation
This is a prospective, randomized, unblinded trial of trauma patients in the ICU who are identified as being at a high risk to develop acute respiratory failure.
- Trial name
- NCT04507425
- Testing
- Standard of Care - Nasal Cannula, High-flow nasal cannula, HFNC plus non-invasive ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Oklahoma
Sleep Disordered Breathing, Alzheimer's Disease
Sleep, Aging and Risk for Alzheimer's Disease
Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial…
- Trial name
- SARA (NCT01962779)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 2 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sleep Apnea Syndromes
Effects of CPAP on Diet, Physical Activity, and Cardiovascular Risk
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete loss of airflow during sleep, due to narrowing or closure of the upper airway.
- Trial name
- NCT01944020
- Testing
- CPAP
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Acute Respiratory Failure
Third International Study on Mechanical Ventilation
The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1.
- Trial name
- ISMV (NCT01093482)
- Where
- 477 sites in United States, Argentina and 36 more
- Volunteers
- 8,151 people
- Sponsor
- Hospital Universitario Getafe
Respiratory Distress Syndrome, Newborn
NIPPV vs.nCPAP During LISA Procedure
The goal of this randomized controlled study is to compare the efficacy of using NIPPV versus NCPAP during the LISA procedure in very preterm infants.
- Trial name
- NIPAL (NCT05796128)
- Testing
- Nasal Intermittent Positive Pressure Ventilation (NIPPV), Nasal continuous positive airway pressure (NCPAP)
- Where
- Italy
- Volunteers
- 202 people
- Sponsor
- University of Florence
Obstructive Sleep Apnea, Insomnia
Evaluation of APAP With SensAwake in OSA and Insomnia Patients
The hypothesis is that APAP with SensAwake improves wake-after sleep onset compared to APAP without SensAwake in a patient population with Obstructive Sleep Apnea Syndrome (OSAS) and Insomnia.
- Trial name
- NCT02721329
- Testing
- APAP, APAP with SensAwake
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Fisher and Paykel Healthcare
Morbid Obesity
Oxygenation Test During General Anesthesia
The study investigates if applying a special ventilatory strategy during anesthesia for laparoscopic gastric by pass, produces less atelectasis and better oxygenation in spite of using 100 % oxygen during pre oxygenation and…
- Trial name
- NCT01559402
- Testing
- CPAP and 100% oxygen, CPAP and 31% oxygen, No CPAP and 100% oxygen
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Västmanland
Obstructive Sleep Apnea
Auto Bilevel Adherence Following a Poor Initial Encounter With Continuous Positive Airway Pressure (CPAP)
The primary objective outcome is the proportion of participants compliant (at least four hours of use per night for all nights) in the Auto Bilevel group compared to the continuous positive airway pressure (CPAP) group after 90…
- Trial name
- BiPAPRescue (NCT02522442)
- Testing
- CPAP, Auto BiLevel
- Where
- 3 sites in United States
- Volunteers
- 51 people
- Sponsor
- Philips Respironics
Obstructive Sleep Apnea, Alzheimer's Disease
Brain Sleep Clearance of Amyloid-Beta Peptides
The 'Amyloid Cascade Hypothesis' posits that the accumulation of a peptide, amyloid beta (Aβ), in the brain is the initiating event in Alzheimer's disease (AD), however, the mechanisms involved are not well understood.
- Trial name
- Brain SCRAPs (NCT02474251)
- Testing
- Continuous positive airway pressure device
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
OSA
A Cross Over Case Control Study of a Vibration Positional Device for Treatment of OSA
Positional therapy is considered as a kind of conservative treatment especially for patients with OSA which varies with body positions, and has been reported to be useful in selected cases especially those with positional OSA.
- Trial name
- NCT02613975
- Testing
- positonal device
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Parkinson's Disease, Sleep Disordered Breathing
Sleep Disordered Breathing and Its Impact on Neuro-cognitive Performance and Quality of Life in Parkinson Disease
The purpose of this study is to determine the impact of sleep and breathing problems during sleep on memory, attention, and general well being (quality of life) in people with Parkinson Disease.
- Conditions
- Parkinson's Disease, Sleep Disordered Breathing, Sleep Obstructive Apnea
- Trial name
- NCT02034357
- Testing
- Neurocognitive function, Sleep evaluations
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Miami