Clinical trials: Caffeine
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07466732
- Testing
- Caffeine, Placabo, No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07469852
- Testing
- Caffeine (300 mg), No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Anaerobic Performance Neuromuscular Performance Cognitive Performance
Low-Dose Caffeine and Taurine Effects on Performance
This study aims to investigate the effects of low-dose caffeine and taurine, administered separately and in combination, on anaerobic, neuromuscular, and cognitive performance.
- Trial name
- CATAP (NCT07466654)
- Testing
- Caffeine, taurine, Caffeine + Taurine
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara University
Preterm Birth, Caffeine
Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support
The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing.
- Conditions
- Preterm Birth, Caffeine, Neonatal Outcomes
- Trial name
- CARES-Pilot (NCT07456670)
- Testing
- Caffeine
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Queen's University
Aerial Duel Performance in Soccer Players
Combined Caffeine and Rhodiola Rosea on Aerial Duel Performance in Soccer
This study will examine whether caffeine (CAF) and Rhodiola rosea (RHO) supplementation, taken alone or in combination, can improve explosive performance and soccer-specific aerial duel performance in trained male soccer players.
- Trial name
- CCRP-AD (NCT07458594)
- Testing
- Caffeine, Rhodiola rosea extract
- Where
- 2 sites in China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Autonomic Nervous System Imbalance
Caffeine and the Autonomic Nervous System
Caffeine consumption has been linked to dysfunction of the autonomic nervous system. In this study the investigators analyze the effects of caffeine containing drinks (including energy drinks and coffee) on ECG based parameters…
- Trial name
- NCT04886869
- Testing
- caffeine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Drug Interaction
KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism
Carvedilol is a non-selective beta-blocker in common clinical use, used to treat hypertension, heart failure, and angina pectoris symptoms associated with coronary artery disease.
- Trial name
- KF2022#4 (NCT06566794)
- Testing
- Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Panic Disorder, Healthy
Neurobehavioral Correlates of Caffeine on Anxiety, Avoidance and Interoception in Healthy Individuals and Panic Disorder.
The current study is a placebo-controlled, double-blind, randomized controlled study using a cross-over design, including Healthy Controls (HC) and participants with Panic Disorder (PD).
- Trial name
- BINCAP (NCT06145490)
- Testing
- Caffeine
- Where
- 2 sites in Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Caffeine
5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics
The goal of this study is to understand how chewing duration affects how quickly caffeine from caffeinated chewing gum appears in the blood and how long higher caffeine levels are maintained.
- Trial name
- NCT07386899
- Testing
- Caffeine 300 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ege University
Pharmacokinetic Study in Healthy Volunteers
Kinetics of Yohimbine in Humans to Explore Sex and CYP2D6 Genotype Interactions
This study investigates the pharmacokinetics of yohimbine in women and men aged 18 to 40 years to explore sex-specific differences in CYP2D6-dependent drug metabolism.
- Trial name
- YOKI-1 (NCT06939608)
- Testing
- Yohimbine, ¹³C₃-caffeine
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Atopic Dermatitis
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
The primary objective of the study is to evaluate the pharmacokinetics (PK) of multiple cytochrome P450 (CYP450) substrates alone and in combination with rocatinlimab in participants with moderate to severe atopic dermatitis (AD).
- Trial name
- NCT05891119
- Testing
- Caffeine, Metoprolol, Midazolam
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- Amgen
Spinal Hypotension, Caffeine
Oral Caffeine and Spinal-Induced Hypotension
Hypotension after spinal anesthesia is critical. Thus several interventions have been proposed to mitigate such effect.
- Trial name
- NCT07076654
- Testing
- Caffeine (200 mg)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cognitive Performance, Physical Performance Enhancement
Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes
The aim of this clinical trial is to examine how caffeine and L-theanine, taken alone or together, affect both physical and cognitive performance in healthy, trained athletes.
- Conditions
- Cognitive Performance, Physical Performance Enhancement, Caffeine and L-theanine Interaction
- Trial name
- NCT07268573
- Testing
- Caffeine, L-theanine, Combined Caffeine and L-Theanine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ulaş Can YILDIRIM
Athletic Performance, Postural Stability
Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes
This randomized, single-blind, placebo-controlled, four-condition crossover study evaluates the acute effects of caffeine gum (~3 mg/kg) and nicotine gum (4 mg) on balance performance in healthy, trained adults.
- Conditions
- Athletic Performance, Postural Stability, Healhty
- Trial name
- NCT07254832
- Testing
- Caffeine Gum 3mg/kg, Nicotine Gum (4 mg)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gülbin Rudarlı
Healthy Volunteers, Safety After Oral Intake
Effects of Energy Drinks on Cardiovascular Endpoints
This is a clinical trial looking at the impact of energy drinks on heart related parameters. The study will enroll 3 participants who will be exposed to 8 different interventions.
- Trial name
- NCT07212803
- Testing
- Energy Drink B
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Apnea of Prematurity
Caffeine Use in the Management of Preterm Infants
This study aims to assess whether extending the duration of caffeine therapy will help preterm infants achieve full oral feeding faster.
- Trial name
- NCT06327152
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Sleep Deprivation, Caffeine
Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)
This clinical trial will be a comparison between personalized recommended caffeine dosing regimen versus the standard recommended caffeine dosing regimen for sustaining performance during sleep deprivation and minimizing side…
- Trial name
- 2B-2 (NCT05588934)
- Testing
- Caffeine Gum
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Acute Kidney Injury
Learning Alerts for Acute Kidney Injury
The primary objective of this study is to determine whether the use of uplift (also known as Conditional Average Treatment Effect - CATE) modeling to empirically identify patients expected to benefit the most from AKI alerting…
- Trial name
- NCT02786277
- Testing
- Alert
- Where
- United States
- Volunteers
- 2,046 people
- Sponsor
- Yale University
Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life.
- Trial name
- GREAT-HF Care (NCT05990296)
- Testing
- Multiprong CDS with referral to pharmacist co-management, Multiprong CDS with GDMT order set, Focused education
- Where
- United States
- Volunteers
- 4,306 people
- Sponsor
- Geisinger Clinic
Medication Abuse
A Health System Wide Evaluation of Clinical Decision Support Tools to Improve PDMP Utilization and Patient Outcomes
This is a study comparing three clinical decision support (CDS) tools to enhance care by easing health care provider review of the Colorado prescription drug monitoring program (PDMP) prior to prescribing opioids (pain…
- Trial name
- NCT04918355
- Testing
- Clinical Decision Support (CDS) alerts
- Where
- United States
- Volunteers
- 3,635 people
- Sponsor
- University of Colorado, Denver