Clinical trials: Conventional therapy
Constitutional Mismatch Repair Deficiency Syndrome, Lynch Syndrome
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally expected to be fast growing and…
- Conditions
- Constitutional Mismatch Repair Deficiency Syndrome, Lynch Syndrome, Malignant Glioma, Recurrent Brain Neoplasm
- Trial name
- NCT02359565
- Testing
- Biospecimen Collection, Conventional Magnetic Resonance Imaging, Diffusion Tensor Imaging
- Where
- 12 sites in United States, Canada
- Volunteers
- 71 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Graft vs Host Disease
A Study to Investigate the Comparative Effectiveness of Ibrutinib in Steroid Dependent/Refractory cGVHD Participants
The purpose of this study is to evaluate the effectiveness of ibrutinib compared to conventional salvage treatments in participants with steroid dependent/refractory chronic graft versus host disease (cGVHD) by measuring overall…
- Trial name
- NCT04852692
- Where
- 8 sites in South Korea
- Volunteers
- 15 people
- Sponsor
- Janssen Korea, Ltd., Korea
Orthopedic Disorder of Spine, Placebo Effect
Clinical Predictive Effects of Mulligan Treatment in Patients With Chronic Neck Pain
The aim of the study is the measurement and comparison of two manual therapy techniques, the Mulligan´s mobilization with movement technique, and de placebo technique, both applicated in patients with subacute neck pain.
- Conditions
- Orthopedic Disorder of Spine, Placebo Effect, Disability Physical
- Trial name
- NCT05004467
- Testing
- Mobilization With Movement Technique
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Universidad Europea de Madrid
Peritoneal Cavity Cancer
Hyperthermic Intraperitoneal Oxaliplatin for Peritoneal Malignancies
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00625092
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Tennis Elbow, Lateral Epicondylitis
The Effect of Blood Flow Restriction Training on Tennis Elbow
The goal of this randomized controlled clinical trial is to investigate the effects of blood flow restriction training on the parameters surrounding tennis elbow afflicted patients including pain, disability, and grip strength.
- Conditions
- Tennis Elbow, Lateral Epicondylitis, Lateral Epicondylitis, Unspecified Elbow
- Trial name
- NCT06490692
- Testing
- Blood Flow Restriction Training, Conventional Strength Training
- Where
- Lebanon
- Volunteers
- 25 people
- Sponsor
- Cairo University
Back Pain, Leeches
Complementary Medicine Practices in Chronic Low Back Pain: Randomized Controlled Trial
To compare the effectiveness of classical physiotherapy and leech therapy in patients with chronic low back pain.
- Conditions
- Back Pain, Leeches, Chronic Pain
- Trial name
- NCT06407492
- Testing
- Leech, Conventional Physiotherapy, Kinesiotape
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Traumatic Brain Injury
Functional and MRI Evaluation of the Robot-assisted and Traditional Rehabilitation Programs on the Muscle
Walk recovery is one of the goals of rehabilitation programs in patients with acquired brain injury. Recent experiences have shown the effectiveness of rehabilitation programs including traditional physiotherapy in combination…
- Trial name
- NCT04768192
- Testing
- Physical Rehabilitation without lokomat, Physical Rehabilitation with Lokomat
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Breast Cancer
Fulvestrant or Tamoxifen in Treating Postmenopausal Women Who Are Undergoing Surgery for Ductal Carcinoma in Situ of the Breast
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using fulvestrant or tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00126464
- Testing
- fulvestrant, tamoxifen citrate, conventional surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer, Urinary Incontinence
The Effects of Pilates in Muscle Strength of the Pelvic Floor as Treatment of Post Prostatectomy Urinary Incontinence
The purpose of this study is to compare the efficacy between a Pilates exercise program and a Pelvic Floor Muscle Training (PFMT) protocol combined with anal electrical stimulation (AES) in muscular pressure strength of the…
- Trial name
- NCT02645136
- Testing
- Pilates, PFMT and AES, Control
- Volunteers
- 115 people
- Sponsor
- Universidade Estadual de Londrina
Colorectal Cancer, Metastatic Cancer
Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients With Recurrent Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs in different ways may kill more tumor cells.
- Conditions
- Colorectal Cancer, Metastatic Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00005944
- Testing
- chemotherapy, fluorouracil, leucovorin calcium
- Where
- 18 sites in Belgium, France
- Sponsor
- UNICANCER
Child, Infant
Outpatient Pediatric Pulse Oximeters in Africa
The primary objective of this clinical trial is to evaluate the performance of three pulse oximeters during outpatient care within Cape Town, South Africa.
- Conditions
- Child, Infant, Respiratory Tract Infections, Hypoxia
- Trial name
- NCT05914324
- Testing
- Phefumla device, LB-01 device
- Where
- South Africa
- Volunteers
- 936 people
- Sponsor
- Johns Hopkins University
Central Sensitization, Manual Therapy
Efficiency of Manual Therapy on Central Sensitization in Patients With Nonspecific Chronic Back Pain
Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input.
- Trial name
- NCT05937503
- Testing
- manual therapy, conventional physiotherapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Atılım University
Rheumatoid Arthritis
Effects of Kinesiotaping for Hands Function in Rheumatoid Arthritis
The aim of this research is to compare the effects of I-shape and fan shape kinesiotape techniques on pain, range of motion, grip strength and ADLs of patients with Rheumatoid Arthritis.
- Trial name
- NCT05039242
- Testing
- Conventional Physical Therapy), Kinesiotaping with I shaped application, Kinesiotaping with Fan-shaped Application
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Sleep Apnea, Obstructive
Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification
Patients who have Obstructive Sleep Apnea (OSA) may have different Continuous Positive Airway Pressure (CPAP)when titrated with different levels of humidification.
- Trial name
- NCT00681083
- Testing
- Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Fisher and Paykel Healthcare
Carpal Tunnel Syndrome, Blood Flow Restriction (BFR) Training Effects
Effect of Blood Flow Restriction on Pain Perception, Grip Strength and Nerve Conductivity in CTS Patients.
The goal of this clinical trial is to investigate the effect of blood flow restriction (BFR) on pain perception, grip strength and nerve conductivity in patients suffering from carpal tunnel syndrome (CTS).
- Trial name
- NCT06574841
- Testing
- Blood Flow Restriction training
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Ahmed ElMelhat
Diabetic Macular Edema
Comparison Between Treatment With Yellow Micropulse Laser and Green Conventional Laser in Diabetic Macular Edema
Macular edema is the most important cause of visual impairment in diabetic patients. Intravitreal injections of antiVEGF (vascular endothelial growth factor) agents and laser treatment are two effective therapies for stabilising…
- Trial name
- NCT01928654
- Testing
- Micropulse laser treatment, Laser modified ETDRS
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Luigi Sacco University Hospital
Multiple Sclerosis
Robot-assisted Gait Training in Multiple Sclerosis Subjects
Aims of the study: This is a randomized-controlled trial to test the effects of robot-assisted gait training on locomotor function and motor unit firing rate in multiple sclerosis subjects with severe gait impairments.
- Trial name
- NCT01435694
- Testing
- Lokomat (Hocoma, Switzerland), Conventional Therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital of Ferrara
Congenital Zika Syndrome
Impacts of a Physical Therapy Protocol on Motor Function in Children With Congenital Zika Syndrome
The study aims to evaluate the effects of a specialized physiotherapy protocol aimed at the motor function of children with Congenital Zika Virus Syndrome.
- Trial name
- NCT06900322
- Testing
- Experimental Group (stimuli and handling; physical therapy [PediaSuit]), control group (conventional physical therapy)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Gabriela Lopes Gama
Photochemotherapy Reaction, Dental Pulp Necrosis
Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study
Microorganisms play a critical role in the etiology and pathogenesis of apical periodontitis. Enterococcus faecalis and Candida sp. are frequently associated with persistent infections.
- Conditions
- Photochemotherapy Reaction, Dental Pulp Necrosis, Polymerase Chain Reaction, Infection
- Trial name
- NCT03212729
- Testing
- ANTIMICROBIAL PHOTODYNAMIC THERAPY, Conventional endodontic treatment
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Periodontitis, Inflammation
Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women
The improvement of maternal and child health remains a key issue in global health. Production and improved accessibility of healthy and nutrient-rich milk-based products could potentially tackle health and nutrition inequalities…
- Trial name
- IMPROVE (NCT03148483)
- Testing
- Early PT, Delayed PT, Fortified Milk
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Westminster
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