Clinical trials: Hydrocortisone
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART B (NCT05751044)
- Testing
- Dasatinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Performance Anxiety
Performance Anxiety Changes With Exercise
This study investigates the effect of high-intense aerobe exercise training (HIIT) and aerobe exercise of low intensity on clinical and physiological parameters (anxiety, activity, cortisol, alpha amylase, heart rate, heart rate…
- Trial name
- PACE (NCT03562312)
- Testing
- high-intensive aerobe exercise, low-intensive aerobe exercise
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Charite University, Berlin, Germany
Adrenocortical Deficiency, Hemodynamic Instability
Single Dose of Etomidate and Adrenal Cortex
we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.
- Trial name
- NCT01792037
- Testing
- Etomidate, Midazolam, methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University
Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia
Personal Versus Hospital-Provided Dolls in Preschool Children
The goal of this study is to evaluate the effects of personal versus hospital-provided dolls on preoperative anxiety and postoperative delirium in preschool children aged 3-7 years undergoing elective adenoidectomy and/or…
- Trial name
- NCT07403773
- Testing
- Hospital-Provided Doll, Personal Doll, No Doll
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postprandial Glycemia, Metabolic Stress
WHNRC (Western Human Nutrition Research Center) Honey Study
The purpose of this research is to compare two snacks, one with honey and nuts and the other with sugar and nuts, on glucose levels before and after eating these snacks.
- Conditions
- Postprandial Glycemia, Metabolic Stress, Cognitive Change, Satisfaction, Personal
- Trial name
- NCT06107231
- Testing
- Honey, Sucrose, Honey plus almonds
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Primary Adrenal Insufficiency
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Patients with chronic adrenal insufficiency need to adapt their hydrocortisone replacement dose in conditions of physical or psychological stress to prevent life threatening adrenal crisis.
- Trial name
- PHYSCA (NCT01450930)
- Testing
- Hydrocortisone intramuscular first, Hydrocortisone subcutaneously first
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Bruno Allolio
Glucocorticoid Effect
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- NCT05919992
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Soccer Performance
Effects of Coordinative Warm-Up Exercise Protocols on the Technical and Cognitive Performance of Soccer Players
The aim of this study is to evaluate the effects of 12 weeks of warm-up protocols administered to elite soccer players on technical-coordination performance and levels of cortisol, adrenaline, noradrenaline, and dopamine…
- Trial name
- NCT06690853
- Testing
- Experimental Coordinative training, Traditional training (control group)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Molise
Leukemia, Lymphoma
Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002471
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 4 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile…
- Conditions
- Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome, Recurrent Juvenile Myelomonocytic Leukemia, Refractory Childhood Acute Myeloid Leukemia
- Trial name
- NCT06247787
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 19 sites in United States
- Volunteers
- 36 people
- Sponsor
- Children's Oncology Group
Adrenal Incidentaloma
Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas
The primary aim of the study is to assess mortality and cardiovascular events potentially linked to cortisol excess in patients with adrenal incidentalomas stratified by cortisol values following the 1-mg overnight dexamethasone…
- Trial name
- NAPACA (NCT04917757)
- Testing
- 1mg Dexamethasone test
- Where
- 2 sites in Germany, Italy
- Volunteers
- 3,656 people
- Sponsor
- Wuerzburg University Hospital
Oral Pyogenic Granuloma
Corticosteroid Intralesional Injection as an Alternative Treatment in Oral Pyogenic Granuloma in the Esthetic Zone.
Gingival Pyogenic granuloma in the esthetic zone represents an esthetic problem. While surgical treatment may not give the premium esthetic demands, corticosteroid may acheive this balance.
- Trial name
- NCT05534334
- Testing
- Solu-Cortef
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Human-Animal Bond, Human-Animal Interaction
Oxytocin Pathways and the Health Effects of Human-Animal Interaction
This study investigates the roles of oxytocin pathways in human-animal interaction.
- Trial name
- NCT03852264
- Testing
- Pet dog, Unfamiliar dog, Nonsocial control
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Menopause, Hot Flashes
Applied Relaxation for Vasomotor Symptoms
The objectives of this study are to compare frequency and severity of moderate to severe vasomotor symptoms in postmenopausal women treated with applied relaxation (AR) with an untreated control-group (CG) and to investigate if…
- Trial name
- NCT01488864
- Testing
- Applied Relaxation (AR)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Elizabeth Nedstrand
Lung Cancer
Yoga Program for Lung Cancer Patients and Caregivers
The goal of this behavioral research study is to learn the opinion of patients and their caregivers about a couple-based Hatha Yoga program (Group 1) during treatment for cancer.
- Trial name
- NCT02196844
- Testing
- Hatha Yoga, Questionnaires, Walk Test
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- M.D. Anderson Cancer Center
Psychological Stress
Presurgical Illustration and Psychological Stress in Mandibular Third Molar Surgery
The aim of this clinical trial is to evaluate the influence of presurgical patient's diagrammatic illustration of mandibular third molar (Wisdom tooth) surgery on degrees of psychological stress.
- Trial name
- NCT07803510
- Testing
- Presurgical Diagrammatic Illustration for Mandibular Third Molar Surgery
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Stress, Cancer Diagnosis
Building Resiliency Among Caregivers of Curvivors and Metavivors
The main purpose of this research study is to assess the feasibility and participants' satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency Program (SMART-3RP) and compare this treatment with…
- Conditions
- Stress, Cancer Diagnosis, Distress, Emotional
- Trial name
- ForTe (NCT05702723)
- Testing
- Smart-3RP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Massachusetts General Hospital
Healthy
The Effect of Mixed Exercise and Metabolic Stress in Relationship to Age in Healthy Men
Aging in men reduces the amount of luteinizing hormone (LH) and testosterone (Te) secreted in each burst. Stress-associated mechanisms introduced by acute illness and chronic disease decrease LH and Te secretion further.
- Trial name
- NCT01800370
- Testing
- Hyperglycemia, Saline, Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dental Anxiety, Dental Pain
Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment
This study aims to evaluate the effectiveness of tactile distraction materials, including play dough, slime, and plush toys, on dental anxiety, pain perception, and physiological stress responses in children undergoing dental…
- Conditions
- Dental Anxiety, Dental Pain, Behavioral Management
- Trial name
- PLAY-DENT (NCT07445594)
- Testing
- Play Dough Distraction, Slime Distraction, Plush Toy Distraction
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Cushing Disease Due to Increased ACTH Secretion
Combination Osilodrostat and Cabergoline in Cushing's Disease
Cushing disease remains a challenging endocrine disorder in which persistent or recurrent hypercortisolism often requires medical therapy after surgery or when surgery is not feasible.
- Trial name
- COSCA-ECD (NCT07603466)
- Testing
- osilodrostat, osilodrostat and cabergoline
- Where
- 5 sites in Iraq
- Volunteers
- 50 people
- Sponsor
- University of Basrah
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