Clinical trials: Hydrocortisone
Adrenal Insufficiency
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a physiologically high HC dose.
- Trial name
- SUPREME CORT (NCT01546922)
- Testing
- Hydrocortisone
- Where
- Netherlands
- Volunteers
- 63 people
- Sponsor
- University Medical Center Groningen
Asthma
Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room
To compare the efficacy and safety of inhaled procaterol (Meptin Air) versus inhaled salbutamol as metered dose inhaler (MDI) reliever of acute exacerbation of asthma not in imminent respiratory failure.
- Trial name
- NCT01091337
- Testing
- Procaterol, Salbutamol
- Where
- Philippines
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical, Inc., Philippines
Asthma
Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function
The proposed study is designed to investigate the pharmacokinetics, pharmacodynamics (as measured by serum cortisol) and safety of GW685698X in subjects with moderate hepatic impairment and in healthy subjects following a single…
- Trial name
- NCT00419237
- Testing
- GW685698X
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Psychological Stress, Academic Stress
Stress Reduction Program for Iraqi Medical Students
A 4-week stress reduction program for medical students during exams, measuring effects on stress, heart rate, blood pressure, and stress hormones (ACTH, cortisol, DHEA).
- Trial name
- SRIMS (NCT07451145)
- Testing
- Mindfulness-Based Stress Reduction Program
- Where
- Iraq
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Thi-Qar
Stress Physiology, Stress Reaction
The Human Stress Response in a Simulated ED Setting
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respond as they do when they come…
- Conditions
- Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence
- Trial name
- NCT04317482
- Testing
- Standard social stress task, Stressful experience in the ED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Esthetic Zone, Single Tooth Lost
Cost Effectiveness of Various Implant Placement Protocols in the Esthetic Zone
Loss of teeth in the anterior upper jaw significantly affects both well-being and chewing function. Nowadays, dental implants are the treatment of choice for replacing missing teeth with fixed dental prostheses and are often…
- Conditions
- Esthetic Zone, Single Tooth Lost, Accuracy of Dental Implants, Dimensional Changes
- Trial name
- NCT05940662
- Testing
- Immediate Implant Placement, Early Implant Placement, Late Implant Placement
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University of Bern
Anxiety
Examining Cortisol and Alpha Amylase in a Healthy Sample of Youth and Adults
The purpose of this study is to investigate how healthy youth and adults' cortisol levels and other hormone levels relate to anxiety levels while they participate in a behavioral task called the Trier Social Stress Task.
- Trial name
- NCT02490280
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma
The goal of this study is to provide sufficient therapy during the time a patients' B-cell Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy) risk category is being determined.
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Mixed Phenotype Acute Leukemia
- Trial name
- NCT06289673
- Testing
- Dexamethasone, Vincristine, Daunorubicin
- Where
- 5 sites in United States
- Volunteers
- 850 people
- Sponsor
- St. Jude Children's Research Hospital
Emotions
Emotions From Salivary Biomarkers in an Architectural Context
Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment.
- Trial name
- Archi'Motion (NCT07507266)
- Testing
- Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Blood Pressure
Metabolic Response to Playing Video Games
The study is investigating the metabolic response to playing competitive non-violent and competitive violent video games. The primary hypothesis is that the metabolic response in the violent game group will differ from the other…
- Trial name
- NCT01809470
- Testing
- FIFA2013, Call of Duty, Watching TV
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College, London
Long COVID
Neurobiological Underpinnings of Neuropsychological Consequences in Long COVID
Objectives: To describe the standardized evaluation of the psychological and cognitive function of long COVID patients and their evolution, to compare immunological and HPA-axis related biomarkers between long COVID patients and…
- Trial name
- Cov-N-Psy (NCT06279936)
- Testing
- Neuropsychological battery, Surveys and symptom severity questionnaires, Blood withdrawal
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Covid19, SARS-CoV Infection
Impact of Perceived Control on Operational Strain: a Study of COVID-19 Pandemic Caregivers and Military Personnel on Operational Missions
Stress is underpinned by a biological reaction of the organism allowing the production of energy to respond to a change in the environment (or stressor).
- Conditions
- Covid19, SARS-CoV Infection, Burnout, Caregiver, Burnout, Professional
- Trial name
- COVID-TRUST (NCT04517136)
- Testing
- Assessment of work-related stress, Saliva sample collection, Cardiac and electrodermal recordings
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Delirium, Cognitive Impairment
Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
There is lack of attention to preoperative cognitive function and delirium in elderly who underwent surgery. The investigators are investigating different tools that can help to screen for cognitive dysfunction and delirium in…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Dysfunction, Cognitive Dysfunction, Postoperative
- Trial name
- NCT05209555
- Testing
- MoCA, BAMCOG, DeltaScan
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Adrenal Insufficiency
A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects
This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed…
- Trial name
- NCT03311932
- Testing
- Infacort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Bulimia Nervosa
Efficiency of Repetitive Transcranial Magnetic Stimulation (rTMS) in Bulimia
Bulimia nervosa is defined by recurrent episodes of binge eating followed by compensatory behaviors (such as induced vomiting) to prevent weight gain.
- Trial name
- rTMS&bulimia (NCT01530906)
- Testing
- Repetitive transcranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Cancer, Skin Toxicities
A Study of Standard of Care Drugs With or Without Ivermectin for Daraxonrasib-Induced Skin Toxicity in People With Pancreatic Cancer
The researchers are doing this study to find out whether the combination of ivermectin and standard of care prophylaxis (SOCP; drugs given to prevent the development of a disease or condition) is an effective treatment approach…
- Trial name
- NCT07895498
- Testing
- Minocycline, Hypochlorous Acid, Hydrocortison cream
- Where
- 7 sites in United States
- Volunteers
- 122 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Traumatic Birth
Glucocorticoid Administration After Traumatic Birth
This study has two components, an observational and a trial component. The observational part is being done to screen for postpartum posttraumatic stress disorder by collecting mental health assessments in women who are…
- Trial name
- NCT04852458
- Testing
- Intravenous (IV) hydrocortisone
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Michigan
Infant Development
Baby Dvd Effects on Cortisol
The investigators will do an experiment where 9-12 month old infants are randomized to 30 minutes of block play or 30 minutes of watching a baby DVD.
- Trial name
- NCT01459848
- Testing
- block play, baby dvd
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
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