Clinical trials: Paracetamol, completed
The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake
Effects of Gum Chewing on Appetite and Digestion
One obvious property difference between energy-yielding beverages and solid foods is the oral mechanical processing required to prepare the two food forms for swallowing.
- Conditions
- The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake, It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean Individuals
- Trial name
- NCT01070212
- Testing
- soft gum, firm gum, no gum
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Purdue University
Prostate Cancer, Anesthesia, Local
Open Radical Prostatectomy and Erector Spinae Plane Block
In the proposed study, a bilateral erector spinae plane (ESP) block [10 ml 1%lidocaine + 10 ml 0.5 % bupivacaine vs normal saline (NS)] will be performed preoperatively to patients undergoing open radical prostatectomy.
- Conditions
- Prostate Cancer, Anesthesia, Local, Pain, Postoperative
- Trial name
- NCT04337060
- Testing
- Single-injection ultrasound-guided bilateral erector spinae plane block-Lidocaine/Bupivacaine, Pain follow-up and monitorization
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- BURHAN DOST
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cholecystectomy, Pain, Postoperative
Nonopioid Analgesics and Cholecystectomy
The goal of this clinical trial is to evaluate the effect of the addition of nefopam to a multimodal analgesic regimen consisting of ketoprofen and paracetamol during sevoflurane- dexmedetomidine-based anesthesia on postoperative…
- Conditions
- Cholecystectomy, Pain, Postoperative, Opioid Use
- Trial name
- NCT04622813
- Testing
- nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol
- Where
- Lebanon
- Volunteers
- 90 people
- Sponsor
- American University of Beirut Medical Center
Upper Respiratory Infections
Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Pseudoephedrine 30 mg Syrup in Patients Suffering a URTI
This is an open label, in-use study to assess the warming sensation, acceptability and local tolerability of paracetamol 500 mg + pseudoephedrine 30 mg syrup, given as a single dose in subjects suffering from symptoms of an upper…
- Trial name
- NCT01586962
- Testing
- IFF flavor 316 282, Paracetamol, Pseudoephedrine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Novartis
COVID-19
A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2)
A multi-centre open-label two-arm randomised superiority clinical trial of two weeks of oral Azithromycin 500mg once daily versus usual care in adult patients presenting to secondary care with clinically-diagnosed COVID-19 but…
- Trial name
- ATOMIC2 (NCT04381962)
- Testing
- Azithromycin Capsule
- Where
- 5 sites in United Kingdom
- Volunteers
- 298 people
- Sponsor
- University of Oxford
Pain Score (VAS)
Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia
Post-dural puncture headache (PDPH) is a well-recognized and potentially serious complication of subarachnoid block. While advancements in spinal needle design have reduced its incidence in recent years, PDPH still affects a…
- Trial name
- NCT06607861
- Testing
- saline group, dexmedetomidine group, lidocaine group
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Minia University
Anesthesia
Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients.
This study is a double blind randomized controlled trial. The investigators randomized ASA III and IV patients who underwent cholangiopancreatography. The investigators gave Propofol or Ketofol and compared the outcomes.
- Trial name
- NCT05473949
- Testing
- Profofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients, Ketofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients
- Volunteers
- 102 people
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Post-operative Pain
Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery
Hypothesis: Postoperative pain will be equivalent in patients receiving preemptive oral acetaminophen as compared to patients receiving preemptive intravenous acetaminophen following minimally invasive benign gynecologic surgery.
- Trial name
- NCT03391284
- Testing
- acetominophen, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Scripps Health
Testicle Undescended, Pain, Postoperative
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
Surgical intervention to treat undescended testis is a very common pediatric surgical procedure, often performed using an inguinal incision or subscrotal incision approach.
- Trial name
- NCT03041935
- Testing
- Ilioinguinal/iliohypogastric nerve block, Caudal-epidural nerve block, Acetaminophen
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Leukemia
S0910 Epratuzumab, Cytarabine, and Clofarabine in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
RATIONALE: Monoclonal antibodies, such as epratuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00945815
- Testing
- epratuzumab, clofarabine, cytarabine
- Where
- 81 sites in United States
- Volunteers
- 35 people
- Sponsor
- SWOG Cancer Research Network
Patency of the Ductus Arteriosus, Acetaminophen
Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen
TREOCAPA is a Phase II/III European Multicentre study concerning the prophylactic treatment by Acetaminophen of extremely preterm infant during the first five days after birth.
- Conditions
- Patency of the Ductus Arteriosus, Acetaminophen, Extreme Prematurity
- Trial name
- TREOCAPA (NCT04459117)
- Testing
- Acetaminophen, NACL 0.9%
- Where
- 36 sites in Belgium, Denmark and 10 more
- Volunteers
- 804 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Osteoarthritis of the Knee
Cupping in Osteoarthritis of the Knee
The purpose of this exploratory randomised trial is to study the effect of pulsatile cupping in osteoarthritis of the knee compared to waiting list control.
- Trial name
- NCT01057043
- Testing
- Pulsatile cupping
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Myeloma
A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma
The purpose of this study is to evaluate the safety, tolerability, and dose regimen of daratumumab when administered in combination with various treatment regimens for the treatment of multiple myeloma.
- Trial name
- NCT01998971
- Testing
- Daratumumab, Velcade, Pomalidomide
- Where
- 22 sites in United States, France and 1 more
- Volunteers
- 240 people
- Sponsor
- Janssen Research & Development, LLC
Hydrogen Peroxide Allergy
The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment.
Background: The administration of the intra-oral drugs was not capable of reducing this side effect, maybe the use of two analgesics may to present better analgesic effect to avoid the bleaching-induced tooth sensitivity (TS).
- Trial name
- NSAIDs (NCT03343392)
- Testing
- acetam/ketoro tromet group
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Uterine Cervical Cancer, Upper Aerodigestive Tract Neoplasms
Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)
The results of the study will permit to set up a standardized and validated procedure of pain management authorizing medical and paramedical staff of brachytherapy department to handle pain and in this way to improve the quality…
- Trial name
- KETOCOL (NCT02439034)
- Testing
- Paracetamol, Ketoprofen
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Oscar Lambret
Fever
Acetaminophen Before Vaccines for Infants Study (AVIS)
The purpose of this study is to see whether giving acetaminophen (the medicine in Tylenol) for routine infant vaccinations is helpful in preventing fever or other symptoms.
- Trial name
- NCT00325819
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Healthy Volunteers
Bioequivalence of a Fixed Dose Combination Tablet Containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl Compared to Two Film Coated Fixed Dose Combination Tablets RhinAdvil(R)(200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl) Administered in Healthy Subjects
Primary objective To demonstrate the bioequivalence of a fixed dose combination tablet containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl vs.
- Trial name
- NCT02963701
- Testing
- Ibuprofen, Pseudoephedrine-HCl
- Where
- South Africa
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pain, Long-bone Fractures
Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children
The main objective of this study is to evaluate the efficacy of two drugs: paracetamol and ibuprofen in association with morphine, compared with morphine alone on analgesia in children seen in the emergency department for a…
- Trial name
- MORPHAPAIN (NCT02477007)
- Testing
- Paracetamol, Ibuprofen, paracetamol + ibuprofen
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Analgesia, Anesthesia, Local
Suprainguinal Fascia Iliaca Block in Knee Arthroplasty
Total knee arthroplasty is the most commonly performed orthopedic surgery, especially in patients with advanced gonarthrosis and limited joint movement. After total knee arthroplasty, patients experience unbearably severe pain.
- Trial name
- NCT06386575
- Testing
- control group; Patients who received physiological saline, suprainguinal fascia block; Patients receiving local anesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.