Clinical trials: sponsored by Baylor Research Institute
Dementia
GamePlan4Care: Online Support for Family Caregivers
As the population of older adults grows, almost doubling in size from 2012 to 2040, so too will the need for family caregiving. Caregiving can lead to negative psychosocial outcomes such as depression, anxiety, and burden; social…
- Trial name
- GP4C (NCT04540198)
- Testing
- GamePlan4Care, Resources4Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Intestinal Anastomotic Leak, Intestinal Perforations
Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations
The purpose of this registry is to collect data on the clinical use of endoluminal vacuum (E-Vac) therapy to treat both upper and lower intestinal leaks and perforations.
- Trial name
- NCT02477930
- Testing
- No interventions are done
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
GERD
Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass
The purpose of this study is to investigate the efficacy of performing a truncal vagotomy along with a sleeve to bypass revision surgery in reducing the severity and/or incidence of gastroesophageal reflux disease (GERD)…
- Trial name
- NCT04901429
- Testing
- Truncal vagotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
GERD
Gastroesophageal Reflux Disease Prospective Registry
The purpose of this registry is to evaluate information to determine which operations and treatments for gastroesophageal reflux disease or similar diseases of the stomach, esophagus or digestive tract are providing the most…
- Trial name
- GERD (NCT02479438)
- Testing
- Diagnosed with GERD
- Where
- United States
- Volunteers
- 744 people
- Sponsor
- Baylor Research Institute
Achalasia
Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders
The purpose of this study is to show that the Per-Oral Endoscopic Myotomy (POEM) procedure is an effective treatment for people with achalasia.
- Trial name
- POEM (NCT02482337)
- Testing
- POEM
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Mitral Annular Calcification
Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study
The purpose of this study is to establish the safety and feasibility of the Edwards SAPIEN 3 valve in subjects with mitral annular calcification (MAC) associated with mitral stenosis (MS) and/or mitral regurgitation who are at…
- Trial name
- SITRAL (NCT02830204)
- Testing
- Mitral Valve Replacement (MVR) with Sapien3
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Delirium, Critical Illness
Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors
Older adults are at risk for ICU-acquired cognitive decline discernible from clinical, biological, and imaging- related changes in the brain following delirium and critical illness.
- Conditions
- Delirium, Critical Illness, Drive
- Trial name
- DRIVE-PICS (NCT05999903)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor Research Institute
Cardiopulmonary, Exercise
COSMED K5 Validation and Reliability Study
To determine the validity of the K5 metabolic system breath-by-breath analysis setting during a high intensity treadmill running protocol compared to the criterion ParvoMedics TrueOne® 2400 automated metabolic gas analysis…
- Trial name
- K5 (NCT05145192)
- Testing
- COSMED K5 CPET (Cardiopulmonary Exercise Test), ParvoMedics CPET
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
COVID-19
Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study
To examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.
- Trial name
- PASC (NCT05218174)
- Testing
- Exercise Prescription
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Baylor Research Institute
Cardiopulmonary, Exercise
Effects of Face Masks During Exercise
To describe the primary and secondary outcomes of athletes during a Cardiopulmonary Exercise Test (CPET) on a cycle ergometer with and without a face mask.
- Conditions
- Cardiopulmonary, Exercise, Cognitive Performance, Covid19
- Trial name
- NCT04833010
- Testing
- Cardiopulmonary Exercise Test, Cognitive Performance Test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Pediatric Disorder
Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen?
To examine the difference in pain control in the pediatric general surgery population alternating acetaminophen and Ibuprofen q 3 hours vs giving them simultaneous combination therapy around the clock.
- Trial name
- NCT06505148
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor Research Institute
Coronary Angiography, Coronary Angioplasty
DIstal vs Proximal Radial Artery Access for Cath
This single-center, prospective, randomized study will evaluate distal radial artery (dRA) vs. proximal radial artery access (pRA) in regards to hand function and radial artery occlusion.
- Trial name
- DIPRA (NCT04318990)
- Testing
- Distal radial artery access, Proximal radial artery surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Baylor Research Institute
Birth Control, Contraception
Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™
Effects of norethindrone acetate (NTA) in patients with Nexplanon.
- Conditions
- Birth Control, Contraception, Implant, Breakthrough Bleeding
- Trial name
- NCT04676061
- Testing
- Norethindrone acetate (NTA)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Overactive Bladder, Dementia
Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder
Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain.
- Conditions
- Overactive Bladder, Dementia, Lower Urinary Tract Symptoms, Incontinence, Urge
- Trial name
- NCT03817931
- Testing
- Anticholinergic, Beta-3 Agonists, Adrenergic, Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Heart Failure, Transplant; Failure, Heart
Shear Wave Elastography
In individuals needing a left ventricular assist device (LVAD), right heart failure (RHF) is a serious complication post-surgery, associated with worsened outcomes including mortality.
- Conditions
- Heart Failure, Transplant; Failure, Heart, Decompensated Heart Failure, Fibrosis, Liver
- Trial name
- NCT04493346
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Baylor Research Institute
Post Traumatic Stress Disorder
Targeted Plasticity Therapy for Posttraumatic Stress Disorder
Posttraumatic stress disorder is a debilitating condition that develops in the aftermath of a traumatic experience, leading to hyperarousal, heightened anxiety, and uncontrolled fear that can be driven by intrusive memories or…
- Trial name
- NCT04064762
- Testing
- Paired Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor Research Institute
Vascular Diseases, Peripheral Artery Disease
Standardized Vascular Rehabilitation Program to Improve Patient Disease and Quality of Life
The purpose of this study is to identify the type of patients being referred for the Vascular Rehabilitation Program (VRP) and to study the success rates of the program according to improvements in walking distance and quality of…
- Conditions
- Vascular Diseases, Peripheral Artery Disease, Peripheral Vascular Diseases
- Trial name
- NCT04335695
- Testing
- Vascular Rehabilitation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor Research Institute
Tricuspid Valve Disease, Tricuspid Regurgitation
Prehab Prior to Undergoing Tricuspid Intervention
This study will aim to standardize the prehabilitation protocol to optimize patients and document the clinical and echo variables that could improve clinical outcomes of tricuspid valve intervention.
- Trial name
- NCT04665583
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor Research Institute
Hepatocellular Carcinoma
Genetic Profiling of Liver Cancer in Patients Undergoing Liver Transplantation
The purpose of this study is to determine whether genetic markers unique to liver cancer are present and to assess usefulness as a diagnostic tool.
- Trial name
- NCT02412579
- Testing
- None - Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Hospitalized Patients 18 Years of Age or Older With Pain
Virtual Reality Pain Study
Investigating pain in hospitalized patients in two groups: virtual reality usage group vs standard of care
- Trial name
- VR Pain (NCT05293275)
- Testing
- EaseVRx Virtual Reality Headset
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute