Clinical trials: open to volunteers, sponsored by Chinese University of Hong Kong
Breast Cancer
Personalized Antiemetic Regimen According to Patients' Pharmacogenetic Profile
The objectives of this study are to determine if pharmacogenetic (PG) analysis of an individual enable optimal selection of antiemetic regimen for patients undergoing the first cycle of AC (Adriamycin + Cyclophosphamide) or FEC…
- Trial name
- NCT07455955
- Testing
- Standard antiemetic regimen or Olanzapine antiemetic regimen
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Renal Stone
Supervised Endoscopic Tele-controlled Intelligent Lithotripsy
This is a phase I feasibility study to investigate the use of a novel intelligent robotic retrograde intrarenal surgery (RIRS) platform.
- Trial name
- SENTINEL-1 (NCT07411391)
- Testing
- RIRS using the TaloStone T1000 RIRS platform
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Catheter-Associated Urinary Tract Infections (CAUTIs)
Evaluate of the Use of Uromune as a Potential Non-antibiotic Prophylactic Strategy for Catheter-associated Urinary Tract Infection in Patients With Long-term Catheterization.
A self-controlled pilot study to evaluate the use of oral bacterial immunotherapy for prevention of catheter-associated urinary tract infection.
- Trial name
- NCT07869992
- Testing
- Uromune
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Diseases, Metabolic Syndrome
HAPA-based Intervention in Adults With Metabolic Syndrome and Chronic Kidney Disease
This study will adopt a 2-arm, pretest-posttest, and assessor-blind RCT design to examine the effectiveness of a theory-based health behaviour change intervention on WC (primary outcome), kidney function (eGFR, primary outcome)…
- Trial name
- NCT06715735
- Testing
- HAPA-based intervention
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Vasomotor Symptoms, Prostate Cancer
A Trial on Fezolinetant for Vasomotor Symptoms in Men Receiving Androgen Deprivation Therapy (ADT)
This is a randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical study to investigates the efficacy of fezolinetant in men undergoing ADT for prostate cancer in alleviating Vasomotor syndromes.
- Trial name
- NCT07568236
- Testing
- Fezolinetant
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Risk, Prostate Cancer
The Effect of Multidisciplinary Care Approach on CV Risk Modification in CaP Patients Receiving ADT
Prostate cancer is characterised by its slow progression nature, and even for metastatic disease, the 5-year survival is up to 30%.
- Trial name
- NCT06163924
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Colorectal Surgery
Assessing the Feasibility of Using Methylene Blue in Identifying Ureters During Colorectal Surgery
This study will assess whether methylene blue fluorescence imaging can help surgeons identify the ureters during colorectal surgery.
- Conditions
- Colorectal Cancer, Colorectal Surgery, Ureteric Injury
- Trial name
- NCT07861815
- Testing
- Intravenous Methylene Blue, Methylene Blue Fluorescence Imaging System
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Psychological Well-being, Gratitude
Effects of School-Based Ignatian Examen Meditation on Well-Being, Gratitude, Hope, and Spirituality in Hong Kong Catholic Primary School Students
This study aims to investigate the effects of Ignatian Examen Meditation on students' psychological well-being, gratitude, hope, and spirituality.
- Conditions
- Psychological Well-being, Gratitude, Hope, Spirituality
- Trial name
- NCT07857980
- Testing
- Examen Meditation
- Where
- Hong Kong
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Anemia Associated With Chronic Kidney Disease
Combination Therapy of Romiplostim and Erythropoiesis-stimulating Agents
The goal of this Phase 2 clinical trial is to learn if adding romiplostim to standard erythropoiesis-stimulating agent (ESA) therapy is safe and tolerated in adults with chronic kidney disease who are on hemodialysis and have…
- Trial name
- NCT07854561
- Testing
- Romiplostim, darbepoetin alfa, Methoxy Polyethylene Glycol-Epoetin Beta
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Chinese University of Hong Kong
Aortic Dissection
Study Comparing Hemiarch Replacement and Hemiarch Plus Stent Implantation in Acute Aortic Dissection
Acute DeBakey type I aortic dissection (ATAD) is one of the most lethal surgical emergencies. The conventional operative strategy is hemiarch replacement under cardiopulmonary bypass support to replace the diseased segment of the…
- Trial name
- RADAR (NCT06044259)
- Testing
- AMDS; Artivion, Atlanta, Georgia, US, Conventional hemiarch replacement
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
ESD Defect, Gastric Epithelial Lesion
Su2ura ESD Closure Pilot Study
This study is a single-center, prospective, single-arm, non-blinded first-in-human (FIH) early feasibility study intended to evaluate the short-term safety and technical feasibility of closure of gastric post-ESD defects using a…
- Trial name
- NCT07843719
- Testing
- Su2ura® GI system
- Volunteers
- 5 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer (CRC) Screening
A Novel Multi-functional Artificial Intelligence System on Treatment Efficacy and Implementation in Colonoscopy
To overcome non-neoplastic polyp (NNP) resections, computer-aided diagnosis (CADx) systems have been developed. In a meta-analysis, the performance of CADx systems was superior to endoscopists.
- Trial name
- mAInstream (NCT07844252)
- Testing
- CADe/CADx
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Well-Being (Psychological Flourishing), Work Related Stress
A Mindfulness-based Intervention for Hotel Staff
This research aims to investigate the potential impact of a structured mindfulness-based professional development program on hotel employees and to explore why and how these changes occur during and after the mindfulness…
- Conditions
- Well-Being (Psychological Flourishing), Work Related Stress, Work Performance
- Trial name
- NCT07541027
- Testing
- A mindfulness-based intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Surgery, Ureter
Randomised Controlled Trial of Fluorescent Urography Using Intravenous Methylene Blue Compared to White Light Alone in Left-sided Colorectal Surgery
This study will see if a blue dye (methylene blue) given into a vein, together with a special camera light, helps surgeons find the left ureter (the tube from the kidney to the bladder) faster during left-sided bowel surgery.
- Trial name
- NCT07835932
- Testing
- Intravenous Methylene blue, Fluorescence Imaging Device for Methylene Blue
- Where
- Hong Kong
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Neoplasia, Colorectal Cancer
The Longterm Risk of Advanced Colorectal Neoplasia After Colonoscopy - A Population-based Cohort Study in Hong Kong
The primary objective of this study is to analyze the 15-year cumulative incidence of advanced colorectal neoplasia and CRC-related mortality after the index colonoscopy.
- Trial name
- ACNC (NCT04815525)
- Where
- Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gastric Cancer, Intestinal Metaplasia
Prediction of Gastric Cancer in Intestinal Metaplasia and Atrophic Gastritis
The primary objectives of this study are: To identify clinical or histological factors associated with gastric cancer development in patients with IM and AG To establish a machine learning algorithm for prediction of future…
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- GIMA (NCT04840056)
- Where
- Hong Kong
- Volunteers
- 1,300 people
- Sponsor
- Chinese University of Hong Kong
Helicobacter Pylori, Atrophic Gastritis
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques.
- Conditions
- Helicobacter Pylori, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT05053945
- Testing
- Esophagogastroduodenoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Adenoma, Advanced Adenoma
Diagnostic Accuracy of M3 in Predicting Colorectal Advanced Adenoma Recurrence (M3-AA)
The investigators aim to evaluate the diagnostic accuracy of FIT and the novel panel of four bacterial gene markers collectively named as M3, to detect recurrent advanced adenomas in patients with history of colonic adenomas.
- Conditions
- Colorectal Adenoma, Advanced Adenoma, Colorectal Polyp
- Trial name
- M3-AA (NCT05144152)
- Testing
- M3, FIT
- Where
- Hong Kong
- Volunteers
- 600 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Neoplasms
A Prospective Study to Evaluate the Diagnostic Accuracy of Computer-aided Diagnosis (CADx) System in Real-time Characterization of Colorectal Neoplasia
The investigators hypothesize that a newly developed CADx system will have a higher diagnostic accuracy in predicting histopathology of colorectal neoplasia than both expert and junior endoscopists.
- Trial name
- CADx (NCT05414383)
- Testing
- CADx
- Volunteers
- 510 people
- Sponsor
- Chinese University of Hong Kong