Clinical trials: sponsored by Fox Chase Cancer Center
Non Small Cell Lung Cancer
Pilot Study to Investigate The Diagnostic Yield and Utility of 22g and 19g Endobronchial Ultrasound Transbronchial Needle Aspirate
Needle biopsy samples are routinely collected to evaluate cytomorphology, immunohistochemical markers and for mutational analysis.
- Trial name
- NCT03311620
- Testing
- Endobronchial ultrasound (EBUS) transbronchial needle aspirate (TBNA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer
Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00021398
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 17 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fox Chase Cancer Center
Unspecified Adult Solid Tumor, Protocol Specific
3-Dimensional Conformal Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Recurrent Tumors
This phase I trial studies the side effects and best dose of 3-dimensional conformal radiation therapy (CRT) or intensity-modulated radiation therapy (IMRT) in treating patients with recurrent tumors.
- Trial name
- NCT01470365
- Testing
- quality-of-life assessment, intensity-modulated radiation therapy, 3-dimensional conformal radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fox Chase Cancer Center
Ovarian Cancer, Pancreatic Cancer
VM110 in Detection of Microscopic Tumors: A Phase I Study
A laproscopic imaging tecgnology that uses a synthetic agent to detect ovarian and pancreatic cancers at an early stage so that patients can get treatment early and prevent the disease from advancing to late stage leading to…
- Trial name
- NCT03286062
- Testing
- Agent VM110 and laproscopic infra-red probe
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fox Chase Cancer Center
Female Breast Carcinoma, Healthy Subject
Technology and Health Communication in Improving Health Outcomes in Patients Scheduled for Mammography
This pilot clinical trial studies how well technology and health communication works in improving health outcomes in patients scheduled for mammography screening.
- Trial name
- NCT04290585
- Testing
- Questionnaire Administration, Telephone-Based Intervention
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Breast Cancer, Lung Cancer
Development of Real-time Image-guided Radiotherapy
The goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. On-board cone-beam CT (CBCT) scans are routinely acquired prior to dose delivery and matched with simulation CT…
- Conditions
- Breast Cancer, Lung Cancer, Skin Cancer
- Trial name
- NCT03524248
- Testing
- Image guided radiation therapy
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Fox Chase Cancer Center
Metastatic Breast Cancer
Improving the Approach to and Management of the Older Metastatic Breast Cancer Patient
The purpose of this study is to enhance the care of older metastatic breast cancer (MBC) patients by increasing awareness among oncology providers as to the unique aspects of care required for older patients.
- Trial name
- NCT03007641
- Testing
- Didactic session, Comprehensive Geriatric Assessment
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer, Colorectal Cancer
Printed Education Materials in Patients Who Are Finishing Treatment for Stage I, Stage II, or Stage IIIA Breast Cancer, Colorectal Cancer, Prostate Cancer, or Chest Cancer
RATIONALE: Printed educational materials, such as the Facing Forward Series: Life After Cancer Treatment manual, may help make the transition from cancer patient to cancer survivor easier in patients who are finishing treatment…
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Malignant Mesothelioma
- Trial name
- NCT00372840
- Testing
- educational intervention, psychosocial assessment and care, quality-of-life assessment
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Fox Chase Cancer Center
Advanced Solid Tumors
Combination of Interferon-gamma and Nivolumab for Advanced Solid Tumors
This is a phase I study of combination immunotherapy with IFN-γ and the PD-1 inhibitor nivolumab in patients with advanced solid tumors who have progressed on at least one prior systemic therapy, which may include prior…
- Trial name
- NCT02614456
- Testing
- interferon-gamma and nivolumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Fox Chase Cancer Center
Locally Advanced Non-small Cell Lung Cancer
Treatment of Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine the maximum tolerated dose of the combination of vorinostat, cisplatin, pemetrexed, and radiation therapy in patients with unresectable stage IIIA/IIIB non-small cell lung cancer.
- Trial name
- NSCLC (NCT01059552)
- Testing
- vorinostat
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Fox Chase Cancer Center
Metastatic Renal Cell Carcinoma, RCC
Study of Ixazomib With Pegylated IFN-alpha 2b (pIFN) in Metastatic Renal Cell Carcinoma (mRCC)
This is a Phase I/II trial of the combination pegylated IFN-alpha 2b with ixazomib in metastatic renal cell carcinoma (mRCC). Researchers believe that by disabling the protein complex NF-kB, which controls the transfer of genetic…
- Trial name
- NCT02447887
- Testing
- Ixazomib, Pegylated IFN-alpha 2b
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Fox Chase Cancer Center
Muscle Invasive Bladder Cancer, High Risk Urothelial Carcinoma of the Upper Urinary Tracts
Dose Dense MVAC for Muscle Invasive Bladder Cancer
Standard treatment for early stage bladder cancer is chemotherapy with methotrexate (M), vinblastine (V), adriamycin (A), and cisplatin (C) followed by surgical removal of any remaining cancer and the bladder with the intent of…
- Trial name
- NCT01031420
- Testing
- single arm dose dense MVAC
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Fox Chase Cancer Center
Malignant Pericardial Effusion, Malignant Pleural Effusion
Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer
This randomized clinical trial studies how well genetic sequencing-informed targeted therapy works in treating patients with stage IIIB-IV non-small cell lung cancer.
- Conditions
- Malignant Pericardial Effusion, Malignant Pleural Effusion, Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
- Trial name
- NCT02132884
- Testing
- cytology specimen collection procedure, therapeutic procedure, targeted therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fox Chase Cancer Center
Distal Urethral Cancer, Proximal Urethral Cancer
Gemcitabine Hydrochloride and Cisplatin Before Surgery in Treating Patients With Muscle Invasive Bladder Cancer
The purpose of this research study is to find out what effects, good and/or bad, dose-dense (every 14 days) chemotherapy with gemcitabine (gemcitabine hydrochloride) and cisplatin given before surgery have on patients and their…
- Conditions
- Distal Urethral Cancer, Proximal Urethral Cancer, Squamous Cell Carcinoma of the Bladder, Stage II Bladder Cancer
- Trial name
- NCT01611662
- Testing
- gemcitabine hydrochloride, cisplatin, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Fox Chase Cancer Center
Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas
Chemoradiation and Radiosurgery Boost in Treating Patients With Locally Advance Pancreatic Cancer That May or May Not be Removed by Surgery
This phase I trial studies the side effects and best dose of radiosurgery boost following chemoradiation in treating patients with locally advanced pancreatic cancer that may or may not be removed by surgery.
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Stage IIB Pancreatic Cancer, Stage III Pancreatic Cancer
- Trial name
- NCT01739439
- Testing
- gemcitabine hydrochloride, hyperfractionated radiation therapy, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Fox Chase Cancer Center
Neuroendocrine Tumor
Molecular Analysis in Tissue Samples From Patients With Advanced or Metastatic Neuroendocrine Tumors
This pilot research trial studies molecular analysis in tissue samples from patients with advanced or metastatic neuroendocrine tumors.
- Trial name
- NCT02092714
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Fox Chase Cancer Center
Fallopian Tube Cancer, Peritoneal Cavity Cancer
A Study of Carboplatin, PLD and Everolimus in Certain Gynecologic Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and pegylated liposomal doxorubicin hydrochloride (PLD) work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Conditions
- Fallopian Tube Cancer, Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
- Trial name
- NCT01281514
- Testing
- everolimus, carboplatin, pegylated liposomal doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Squamous Cell Carcinoma of the Head and Neck
Impact of Ribociclib on Head and Neck Squamous Cell Cancer
A window of opportunity study which would allow brief treatment of HPV negative SCCHN with a CDK4/6 inhibitor, in the pre-operative setting, with biomarker analyses of pre and post treatment tissue.
- Trial name
- NCT03179956
- Testing
- Ribociclib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fox Chase Cancer Center
Ovarian Papillary Serous Carcinoma, Ovarian Serous Cystadenocarcinoma
Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase I trial studies the side effects and best way to give metformin hydrochloride, carboplatin, and paclitaxel in treating patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer.
- Conditions
- Ovarian Papillary Serous Carcinoma, Ovarian Serous Cystadenocarcinoma, Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer
- Trial name
- NCT02050009
- Testing
- metformin hydrochloride, carboplatin, paclitaxel
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Breast Cancer
Pilot Study of an Intimacy Enhancement Intervention for Couples Facing Breast Cancer
The central goal of this study is to examine the feasibility, acceptability, and preliminary efficacy of the IE intervention on patient and partner sexual QOL and relationship outcomes, and on patient psychosocial outcomes.
- Trial name
- NCT02721147
- Testing
- Intimacy Enhancing Intervention, Living Healthy Together, Partner-Assisted Coping Skills Training
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Fox Chase Cancer Center