Clinical trials: sponsored by Institut National de la Santé Et de la Recherche Médicale, France
Common Variable Immunodeficiency
"Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency
The main objective of this study is to evaluate and to compare the specific antibody response to a " prime-boost " vaccine strategy combining the seven valence pneumococcal conjugate vaccine (PnCj) prime at W0 followed by the…
- Trial name
- EVAD (NCT01489618)
- Testing
- PPS, PnCJ PPS
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dilated Cardiomyopathy
PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors
This is a multicentre European double-blind,randomized and controlled trial with 2 parallel groups (1 study medication, 1 placebo) in order to analyse the impact of ACE inhibitors (ACEi) in subjects who carry a mutation but have…
- Trial name
- PRECARDIA (NCT01583114)
- Testing
- perindopril
- Where
- 7 sites in Denmark, France and 5 more
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Normal Volunteers
Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Citalopram on Motivation
The aim of the current study is to examine the role of serotonin on the cognitive parameters of motivation. They are embedded in a conceptual framework of motivation that merges decision-making and reinforcement learning…
- Trial name
- MBBCitalopram (NCT02113943)
- Testing
- Citalopram 30mg
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Xerostomia
Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication
Dry mouth is in most cases due to iatrogenic causes, particularly drugs. The existing products such as saliva substitutes are often disappointing (bad taste, poor efficiency).
- Trial name
- LactoXeros (NCT01960101)
- Testing
- LactoXeros, Aequasyal
- Where
- 2 sites in France
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart Failure, Dyspnea
Diagnostic and Prognostic Value of New Biomarkers in Patients With Heart Disease
The objective of this work is to investigate and then to sequence new biomarkers in the plasma of patients presenting with dyspnea secondary or not to heart failure, and study their diagnostic and prognostic value.
- Conditions
- Heart Failure, Dyspnea, Pulmonary Disease
- Trial name
- NCT01374880
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Essential Tremor
Experimental Therapeutics in Essential Tremor Using Transcranial Direct Current Stimulation
The purpose of this study is to determine whether transcranial direct current stimulation (tDCS) delivered over the motor cortex or the cerebellum can improve essential tremor and to identify the cerebral mechanisms involved in…
- Trial name
- ELECTRE (NCT01579435)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Premature
Effect of Docosahexaenoic Acid (DHA)-Enriched Human Milk in Premature Newborns
Several recent publications showed a reduction in the level of DHA and/or an increase in the arachidonic acid (AA)/DHA ratio in the milk of mother.
- Trial name
- DHARMA (NCT01062373)
- Testing
- Supplementation of lactating mothers who has delivered prematurely with DHA
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Effect of Sitaxsentan on Airway Remodeling in Severe Asthma
Study on the Effects of Sitaxsentan on Airway Remodeling in Patients With Severe Asthma
Introduction. Despite adequate steroid therapy, a subpopulation of approximately 10% of asthmatics develops severe persistent airflow obstruction.
- Trial name
- Sitax (NCT01050491)
- Testing
- sitaxentan
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Sleep Apnea
A Community Pharmacist-led Intervention to Improve Screening of Sleep Apnea in Primary Care
The purpose of this study is to evaluate the feasibility and the effectiveness of sleep apnea screening program for patients at risk in community pharmacies.
- Trial name
- NCT01552083
- Testing
- screening of sleep apnea
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart Failure
Identification Of Blood Markers For Asymptomatic Ventricular Dysfunction
The diagnosis of asymptomatic left ventricular dysfunction is difficult in general practice since it requires transthoracic cardiac echocardiography that is generally performed in specialized services.
- Trial name
- IBLOMAVED (NCT01024049)
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Abstract Thinking, Concept Formation
Prefrontal Cortex and Abstract Thinking
The capacity of concept formation is not well understood, even if a link is supposed with the functioning of the frontal lobes. Our aim is to better understand the cognitive mechanisms underlying this function and to try to…
- Trial name
- NCT01100281
- Testing
- Neuropsychological examination, MRI
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Obstructive Pulmonary Disease
Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD)
This study was designed to test the following hypothesis: To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.
- Trial name
- ExaEMS2005 (NCT01167283)
- Testing
- Electrostimulation
- Volunteers
- 15 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
It has been suggested that a low dietary intake of antioxidant vitamins and minerals increases the incidence rate of cardiovascular disease and cancer.
- Trial name
- NCT00272428
- Testing
- ascorbic acid, vitamin E, beta carotene, selenium, zinc
- Where
- France
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pedophilia
Comparison of Two Pharmacological Treatments of Pedophilia
Sexual abuse committed on children is a major public health problem because of its frequency and its severe consequences on the mental health of victims.
- Trial name
- PCNET (NCT00601276)
- Testing
- leuprorelin, Cyproterone acetate
- Where
- 4 sites in France
- Volunteers
- 48 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease
Functional Characterization of Parkin + Patients
Parkinson's disease is one of the most frequent neurodegenerative diseases, and for which the mechanisms remains unknown. Since the implication of susceptibility factors is highly suspect, we have recently shown that one…
- Trial name
- NCT00142311
- Where
- 14 sites in France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease, Epilepsy
Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies
The DNA and Cell Bank of Instituts Federatifs de Recherche (IFR) of Neurosciences has been running for the last 15 years at the Institut National de la Santé Et de la Recherche Médicale (INSERM) Unit 679 (former unit 289).
- Trial name
- NCT00142363
- Where
- 15 sites in France
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France