Clinical trials: completed, sponsored by Institut National de la Santé Et de la Recherche Médicale, France
- Lead sponsor (exact) Institut National de la Santé Et de la Recherche Médicale, France
- Status Completed
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Coronavirus
Viral Excretion in Contact Subjects at High/Moderate Risk of Coronavirus 2019-nCoV Infection. COVID-19.
In December 2019, a pneumonia due to a novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, in China. In a few weeks, the number of confirmed cases of SARS-CoV-2 infection has dramatically increased, with almost 150'000…
- Trial name
- Cov-CONTACT (NCT04259892)
- Testing
- 2019-nCoV PCR
- Where
- 16 sites in France, French Guiana
- Volunteers
- 324 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
Transcriptomics Signature of Anti Vaccinia Memory B Cells
Analyse the transcriptomic signature of anti vaccinia memory B cells at a short time after vaccination as compared to the signature already established in long-lived memory B cells.
- Trial name
- NCT02556489
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
General Population
STUDY OF THE COVID-19 EPIDEMIC AND SOCIO-ECONOMIC LIVING CONDITIONS IN FRANCE
EpiCov is a population-based cohort which aims to provide national and regional estimates of seroprevalence of SARS-CoV-2 infection and analyse relations between living conditions and the dynamics of the epidemic in France.
- Trial name
- EpiCov (NCT05336604)
- Where
- France
- Volunteers
- 134,391 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cortical Organisation of Vestibular Integration
Vestibular Cortex and TMS
In human, the cerebral cortex forms a network of vestibular cortical areas which functional role remains unknown. In patients with localised cortical lesions the investigator has previously demonstrated that the parieto-temporal…
- Trial name
- CoVest (NCT01779752)
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Huntington Disease
Dance and Huntington Disease
In this project investigators will evaluate the benefits of contemporary dance training using a comprehensive test battery combining standard neuropsychological batteries, psychological questionnaires on emotion, empathy and…
- Trial name
- NCT01842919
- Testing
- Kinesthetics tests, Psychological questionnaires, structural Magnetic ResonanceImaging (MRI)
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Apathy, Behavior
Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
The purpose of this study is to provide relevant quantitative evaluation of apathy close to real life situation by means of a multimodal sensor system integrated.
- Conditions
- Apathy, Behavior, Frontotemporal Dementia
- Trial name
- ECOCAPTURE (NCT02496312)
- Testing
- Evaluation of Apathy Close to Real Life Situation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity
Obesity and Lipids: a Matter of Taste?
The purpose of the protocol is to determine the impact of bariatric surgery on taste receptors and taste perceptions and to precise the factors implicated in taste alterations in 50 obese patients before and 6 months after…
- Trial name
- HumanFATaste (NCT02497274)
- Testing
- taste assessment and epithelium gustatory smear and biopsy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Renal Insufficiency, Chronic
Chronic Kidney Disease - Renal Epidemiology and Information Network
Preserving kidney function and improving the transition from CKD to End stage renal disease (ESRD) is a research and healthcare challenge.
- Trial name
- CKD-REIN (NCT03381950)
- Where
- France
- Volunteers
- 3,033 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Multiple Sclerosis
The Energetic Origin of Neurodegeneration in MS
In multiple sclerosis (MS), the sequence of events leading to irreversible neuro-axonal degeneration, which is a major determinant of clinical disability, is poorly understood.
- Trial name
- ENERGYSEP (NCT04532944)
- Testing
- imaging of energy dysfunction
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Delayed Union After Fracture of Humerus, Tibial or Femur
Evaluation of Efficacy and Safety of Autologous MSCs Combined to Biomaterials to Enhance Bone Healing
Bone grafting is widely used in hospitals to repair injured, aged or diseased skeletal tissue. In Europe, about one million patients encounter a surgical bone reconstruction annually and the numbers are increasing due to our…
- Trial name
- OrthoCT1 (NCT01842477)
- Testing
- Implantation of bone substitute plus autologous cultured mesenchymal cells
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disability
Research and Characterization of New Genes Involved in Intellectual Disability
Intellectual disability (ID) occurs in 2 to 3 % of the general population but the cause is identified only in 30 to 60% of cases.
- Trial name
- GeneDefi (NCT01867554)
- Testing
- gene analysis
- Where
- France
- Volunteers
- 8,500 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Huntington Disease
A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease
In the study the investigators plan to include 100 early affected HD patients (5 ≤ UHDRS ≤ 40) in a randomized, double-blind, controlled study in 2 centers (France and the Netherlands).
- Trial name
- TRIHEP3 (NCT02453061)
- Testing
- Triheptanoin oil
- Where
- 2 sites in France, Netherlands
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer's Disease, Dementia
Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment
Patients with different types of dementia will be recruited and evaluated in national hospital departments for their usual neurological follow-ups.
- Conditions
- Alzheimer's Disease, Dementia, Neurodegenerative Disorders
- Trial name
- NCT00149175
- Testing
- Blood sampling, skin biopsy
- Where
- 12 sites in France
- Volunteers
- 2,256 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Apathy, Behavioral Variant Frontotemporal Dementia (bvFTD)
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
Apathy is defined as a quantitative reduction in voluntary and goal-directed behavior. To address this, the investigators propose an ethological approach to assess apathy objectively and quantitatively by observing patients in…
- Conditions
- Apathy, Behavioral Variant Frontotemporal Dementia (bvFTD), Disinhibition, Depression - Major Depressive Disorder
- Trial name
- ECOCAPTURE (NCT03272230)
- Testing
- ECOCAPTURE, Cognitive and Behavioral experimental tasks, Neuropsychological assessment
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Friedreich Ataxia
Evaluation of the Effect of Artesunate in Friedreich Ataxia (FA)
This dose-escalation study is aimed at investigating a novel application for artesunate in the treatment of Friedreich ataxia. It will evaluate this novel application of oral artesunate using a surrogate biological marker as…
- Trial name
- ARTEMIS (NCT04921930)
- Testing
- Artesunate Oral Product
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Soft Tissue Sarcoma
Molecular Profiling of Advanced Soft-tissue Sarcomas
MULTISARC is a randomized multicenter study assessing whether high throughput molecular analysis (next generation sequencing exome - NGS) is feasible in advanced/metastatic soft-tissue sarcoma patients, that is, whether NGS can…
- Trial name
- MULTISARC (NCT03784014)
- Testing
- Nilotinib, Ceritinib, Capmatinib
- Where
- 17 sites in France
- Volunteers
- 603 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
To Validate a Decision Aid for Ectopic Pregnancy
Development and Validation of a Therapeutic Decision Aid in Ectopic Pregnancy: GEUDECID Study
The aim's study is to validate a therapeutic aid in women with a less active ectopic pregnancy. A prospective recrutement of 100 women will be performed in 16 different hospitals in France.
- Trial name
- GEUDECID (NCT05745831)
- Testing
- Therapeutic decision tool
- Where
- 15 sites in France
- Volunteers
- 109 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depressive Disorder
European Comparative Effectiveness Research on Internet-based Depression Treatment
To compare the clinical impact and cost-effectiveness of blended Cognitive Behavioural Therapy (CBT) for adults with major depressive disorder (MDD) with treatment as usual (TAU).
- Trial name
- E-COMPARED (NCT02542891)
- Testing
- Blended CBT, Treatment as Usual (TAU)
- Where
- 10 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France