Clinical trials: sponsored by McMaster University
Cancer, Aging
Virtual Peer-support Exercise Intervention for Older Adults with Cancer
Background: By 2030, 23% of Canadians will be over 65 years of age. Two in five of these individuals will be diagnosed with cancer.
- Trial name
- NCT05549479
- Testing
- Peer Matching, Qualified Exercise Professional Support Sessions
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Long COVID
Cognitive Rehabilitation for Long COVID
The investigators are comparing two different methods for helping adults with Long Coronavirus (COVID) also known as Post-Coronavirus Syndrome or Post-Coronavirus Condition manage everyday cognitive challenges.
- Trial name
- STAR-C3 (NCT05676047)
- Testing
- Cognitive Rehabilitation, Education
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Mild Traumatic Brain Injury
Symptom-Targeted Rehabilitation for Concussion
The investigators are comparing two methods for helping improve everyday cognitive functioning in Canadian Armed Forces (CAF) veterans who have sustained a mild traumatic brain injury (mTBI).
- Trial name
- STAR-C2 (NCT05520710)
- Testing
- Cognitive Rehabilitation, Education
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- McMaster University
Oncology
Remote Education Strategies Training Oncology Residents for End-of-Life Discussions
Difficult conversations are common in oncology practice and patient-centered communication is essential to care for individuals with cancer.
- Trial name
- RESTORED (NCT05810987)
- Testing
- RESTORE, Medical Interaction and Coaching
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mild Traumatic Brain Injury, Concussion, Chronic Dizziness
Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms
This study aims to determine whether the delivery of brain stimulation paired with a balance training task can improve symptoms of dizziness for individuals experiencing these symptoms due to concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Chronic Dizziness, Vestibular Problem
- Trial name
- NCT06735157
- Testing
- Repetitive transcranial magnetic stimulation, Augmented reality vestibular rehabilitation therapy
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Menstrual Cycle, Resistance Exercise
Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on Muscle Protein Synthesis
Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estrogen and progesterone) influence…
- Conditions
- Menstrual Cycle, Resistance Exercise, Muscle Protein Synthesis, OCP
- Trial name
- NCT05347667
- Testing
- Unilateral Resistance Exercise Leg, Control Leg
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Kidney Diseases
A Virtual Post-Discharge Intervention For Patients With CKD
This pilot, interventional study is testing a combination of remote, virtual interventions, delivered to patients at home to patients with chronic kidney disease (CKD), with the goal of reducing admissions to hospital.
- Trial name
- VIDIO-CKD (NCT05274347)
- Testing
- Muti-faceted virtual, remote intervention
- Volunteers
- 30 people
- Sponsor
- McMaster University
Child Behavior Problem, Parenting
Promoting Healthy Families: A Canadian Evaluation
Interventions that promote safe, stable, and nurturing relationships between caregivers and children are key to improving healthy family relationships, reducing child socioemotional and behaviour problems, and preventing child…
- Trial name
- PHF (NCT04702191)
- Testing
- Triple P, Circle of Security Parenting
- Where
- Canada
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes Mellitus, Type 1
Healthy Outcomes for Muscle with Exercise in T1D
Over 300,000 people in Canada suffer from Type 1 Diabetes (T1D), a chronic condition whose incidence rate has been increasing in Canada every year by 5.1% (higher than the global average).
- Trial name
- HOME T1D (NCT05740514)
- Testing
- Exercise, De-training
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- McMaster University
Multiple Sclerosis
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
The goal of this clinical trial is to test the impact of a novel dual-task EMG Biofeedback training method for improving balance in individuals living with multiple sclerosis.
- Trial name
- MSBAL (NCT06461741)
- Testing
- Integrated Dual-task EMG Biofeedback Training (EMG-BF), Traditional Balance Exercise Training (BAL-EX)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Stroke
Power Exercise for Stroke Recovery: The POWER Feasibility Trial
Post-stroke deficits are highly common and functional impairment persists throughout life after stroke. Skeletal muscle mass and strength are fundamental contributors to mobility throughout the adult life course.
- Trial name
- POWER-F (NCT05816811)
- Testing
- Power-focused resistance training
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Inflammatory Bowel Diseases
AIRE-2 Device for Study of Breath Analysis in IBD
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet, symptoms, and microbial fermentable features in IBD…
- Trial name
- AIRE-2 (NCT06541938)
- Testing
- low FODMAP diet, Lactose Sachet, Fructose Sachet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Opioid Use, Pain, Postoperative
Timing of TAP Blocks in Bariatric Surgery
This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is…
- Trial name
- NCT06270147
- Testing
- Bupivacaine-epinephrine
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Soft Tissue Sarcoma, Lung Metastases
Surveillance AFter Extremity Tumor surgerY
Following treatment for a primary extremity sarcoma, patients remain at risk for the development of local and systemic disease recurrence.
- Trial name
- SAFETY (NCT03944798)
- Testing
- Frequency: Every 3 Months, Frequency: Every 6 Months, Imaging Modality: Chest Radiograph (CXR)
- Where
- 35 sites in United States, Argentina and 12 more
- Volunteers
- 310 people
- Sponsor
- McMaster University
Dementia, Behavior
Deprescribing Antipsychotics in Long-Term Care
Aggressive behaviours in long-term care (LTC) is a difficult health care issue to manage. One method that has been over-used is the prescription of antipsychotics for the behaviours and psychological symptoms of dementia (BPSD).
- Trial name
- NCT02958800
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- McMaster University
Influenza
Adjuvanted Inactivated Vaccine Versus Inactivated Influenza Vaccine in Hutterite Children
This study is a randomized controlled trial (RCT) comparing adjuvanted influenza vaccine (AV) to unadjuvanted inactivated influenza vaccine (IIV). Children in Hutterite colonies in Alberta and Saskatchewan will receive AV or IIV.
- Trial name
- NCT02871206
- Testing
- Fluad, Fluzone
- Where
- Canada
- Volunteers
- 3,425 people, healthy volunteers welcome
- Sponsor
- McMaster University
Femoroacetabular Impingement, Cartilage Damage
Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Bone Marrow Aspirate Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Femoroacetabular impingement (FAI) is a hip disorder resulting from a mismatch of the hip joint, resulting in hip pain and can potentially cause osteoarthritis.
- Trial name
- CHASE (NCT04875767)
- Testing
- HA-based scaffold with BMA (Hyalofast®; Anika Therapeutics, Bedford, MA, USA)
- Sponsor
- McMaster University
COPD
Sputum-guided Treatment With Comprehensive Care Management in COPD - A Randomized-controlled Trial
Chronic obstructive pulmonary disease (COPD) is a lung condition affecting 1 in 6 Canadians and does not have a cure. Flare-ups of COPD are the most common reason someone goes to hospital in Canada.
- Trial name
- STRIVE (NCT04890938)
- Testing
- Sputum-guided management and comprehensive care management, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 128 people
- Sponsor
- McMaster University
Skeletal Muscle Protein Synthesis
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome
Generally, resistance exercise increases muscle mass and strength, and fatigue resistance. How resistance exercise achieves these adaptations remains understudied, but what is known is that skeletal muscle translates the physical…
- Trial name
- NCT04263714
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University