Clinical trials: sponsored by McMaster University
Eating Disorder
Omega-3 Fatty Acids as Adjunctive Treatment for Adolescents With Eating Disorders
Eating disorders are conditions that are defined by abnormal eating habits that involve insufficient or excessive food intake. With regards to treating these disorders, there is an increasing interest in fat deprivation due to a…
- Trial name
- NCT01985178
- Testing
- Omega-3 Fatty Acid Supplement
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University
Volunteers
Exploring Volunteers' Experiences in Health TAPESTRY
This study is meant to evaluate the Health TAPESTRY volunteer program. The objective of this study is to explore volunteer experiences in Health TAPESTRY in terms of implementation and to understand how participation in Health…
- Trial name
- NCT03453450
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- McMaster University
Ventilator Associated Pneumonia, Infections
Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
Probiotics are commercially available live bacteria thought to have health benefits when ingested. A literature review of probiotic studies in the intensive care unit (ICU) found that in patients who receive probiotics, there is…
- Conditions
- Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea
- Trial name
- PROSPECT (NCT02462590)
- Testing
- L. rhamnosus GG - Probiotic
- Where
- 44 sites in United States, Canada and 1 more
- Volunteers
- 2,650 people
- Sponsor
- McMaster University
Head and Neck Neoplasms, Squamous Cell Carcinoma
A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck
To evaluate the tumour response rate of squamous cell carcinoma of the head and neck following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every 3-4 days, such that treatment is completed within 15…
- Conditions
- Head and Neck Neoplasms, Squamous Cell Carcinoma, Squamous Skin Carcinoma
- Trial name
- SHINE (NCT04435938)
- Testing
- Stereotactic Body Radiotherapy (SBRT)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Femoral Neck Fractures
Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)
The purpose of this study is to determine the impact of surgical fixation (cancellous screws versus sliding hip screws) and biologic intervention (Vitamin D versus placebo) on patient important outcomes.
- Trial name
- FAITH-2 (NCT01908751)
- Testing
- Sliding Hip Screw, Cancellous Screws, Vitamin D
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 91 people
- Sponsor
- McMaster University
Coronavirus Infection, Coronavirus
The McMaster Multi-Regional COVID-19 Hospital Case Registry
The McMaster Multi-Regional Hospital Coronavirus Registry (COREG) is a platform that is collecting detailed case data on laboratory confirmed COVID-19 hospital inpatients and outpatients.
- Conditions
- Coronavirus Infection, Coronavirus, SARS-CoV-2 Infection, Covid19
- Trial name
- COREG (NCT04508959)
- Where
- 5 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- McMaster University
Asthma
Assessment of SOLO Vibrating Mesh Nebulizer for Allergen-Induced Late Asthmatic Responses
This is a mechanistic study. Having established safety with the Solo® nebulizer and the ability to predict allergen PD20 using the methacholine PD20 and STE, the current study will assess the use of the Solo® vibrating mesh…
- Trial name
- SOLO-LAR (NCT04630405)
- Testing
- Wright jet nebulizer, Aerogen Solo
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Knowledge
Good Shepherd: Back to Reality Series
The purpose of this pilot study is to explore whether the Back to Reality series of video games - Harry's Journey, Harry's Journal, and Pathways to care map - increase knowledge of the emotional, social, and psychiatric sequelae…
- Trial name
- NCT02710019
- Testing
- Back to Reality Series Video Games, Control Video Game
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- McMaster University
Excessive Weight Gain in Pregnancy as Antepartum Condition, Obesity
Be Healthy in Pregnancy (B-HIP): A Trial to Study Nutrition and Exercise Approaches for Healthy Pregnancy
Weight gained during pregnancy is referred to as gestational weight gain (GWG). Excess GWG is a widespread problem that occurs in 55-75% of Canadian women who enter pregnancy overweight or obese (a group that represents over 50 %…
- Conditions
- Excessive Weight Gain in Pregnancy as Antepartum Condition, Obesity, Weight Gain, Type 2 Diabetes
- Trial name
- BHIP (NCT01693510)
- Testing
- Exercise and Nutrition Intervention
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- McMaster University
Pregnancy Complications, Weight Gain
Be Healthy in Pregnancy (BHIP) With Nutrition and Exercise
Excess weight gain in pregnancy is a major problem affecting 55-75% of Canadian women who enter pregnancy overweight or obese and about 40% of women who are normal weight.
- Trial name
- BHIP (NCT01689961)
- Testing
- Structured + monitored nutrition and exercise intervention
- Where
- 4 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Immune Thrombocytopenic Purpura
A Trial of Eltrombopag or Intravenous Immune Globulin Before Surgery for Immune Thrombocytopenia Patients
This is a study to investigate if eltrombopag can be used instead of Intravenous Immune Globulin (IVIG) in patients with ITP, to adequately raise their platelet count when they undergo minor or major surgery.
- Trial name
- NCT01621204
- Testing
- Eltrombopag, IVIG infusion
- Where
- 10 sites in Canada, Netherlands
- Volunteers
- 74 people
- Sponsor
- McMaster University
Comorbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking so many together can do more harm than good.
- Trial name
- TAPER (NCT02562352)
- Testing
- TAPER program
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Emotional Problems, Behavior Problems
A Targeted Prevention Approach to Reducing Child Emotional and Behaviour Problems
The purpose of the study is to evaluate the first Canadian implementation project of the Family Check up (FCU), an evidence-based prevention and early intervention model that engages families and communities in reducing the…
- Trial name
- NCT02800603
- Testing
- Family Check Up
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Gastrointestinal Hemorrhage
Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial
This study tests the feasibility of a large study of stress ulcer prophylaxis in critically ill children. Children admitted to the Pediatric Intensive Care Unit who are expected to require mechanical ventilation for more than 48…
- Trial name
- PIC-UP (NCT02929563)
- Testing
- Pantoprazole
- Where
- 7 sites in Canada
- Volunteers
- 116 people
- Sponsor
- McMaster University
Crohn's Disease
Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD)
This study evaluates the effect of Exclusive Enteral Nutrition (EEN) in addition to different regimes of corticosteroid (CS) therapy (Prednisone) compared to CS alone in adults participants with active Crohn's Disease, on…
- Trial name
- EENCD (NCT03833596)
- Testing
- Prednisone, Exclusive Enteral Nutrition
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- McMaster University
Social Phobia
Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)
SSRI's are considered first-line treatments for GSP, however many patients continue to have significant symptoms despite an adequate trial of an SSRI.
- Trial name
- NCT00182455
- Testing
- Topiramate
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McMaster University
Psychoeducation
Psychoeducational Video Series - Proof of Concept
The purpose of this study is to produce and then assess a psychoeducational video series intended for use amongst an adult attention deficit/hyperactive clinical population.
- Trial name
- NCT04170868
- Testing
- ADHD Psycheducation
- Sponsor
- McMaster University
Obsessive Compulsive Disorder
Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)
SRI's are considered first-line treatments for OCD, however many patients continue to have significant symptoms despite an adequate trial of an SRI.
- Trial name
- NCT00182520
- Testing
- Topiramate
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- McMaster University
Femoroacetabular Impingement
Femoroacetabular Impingement RandomiSed Controlled Trial
The purpose of this study is to determine whether surgical correction of hip impingement morphology via arthroscopic osteochondroplasty (shaving of bone) will provide improved clinical results (decreased pain and improved…
- Trial name
- FIRST (NCT01623843)
- Testing
- Arthroscopic Lavage, Arthroscopic Osteochondroplasty
- Where
- 10 sites in Canada, Denmark and 1 more
- Volunteers
- 220 people
- Sponsor
- McMaster University