Clinical trials: sponsored by McMaster University
Knee Arthritis Osteoarthritis
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial
Knee osteoarthritis (OA) is a common cause of pain and disability in older adults. Many people with knee OA believe that pain is primarily caused by joint damage or "wear and tear." These beliefs may contribute to fear of…
- Trial name
- NCT07823673
- Testing
- Pain Science Education, Biomedical Education
- Volunteers
- 82 people
- Sponsor
- McMaster University
Post Traumatic Stress
Trauma Informed Goal Management Training With a "Support Person" Module for Individuals Impacted by Post-Traumatic Stress
The purpose of this study is to determine whether adding a Support-Person Module to Trauma-Informed Goal Management Training (TIGMT) can improve engagement and recovery among individuals who have experienced traumatic events and…
- Trial name
- TIGMT-Assist (NCT07797543)
- Testing
- Trauma-Informed Goal Management Training (TIGMT), Trauma Informed Goal Management Training - Assist (TIGMT-Assist)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- McMaster University
Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
Cannabis is the most commonly used psychoactive substance in Canada (Lowry \& Corsi, 2020). A sub-group of cannabis users develop a condition known as Cannabis Use Disorder (CUD), which is defined as a regular pattern of cannabis…
- Trial name
- PSI_CUD (NCT06225232)
- Testing
- Psilocybin combined with Psychotherapy
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis
People with knee arthritis often experience constant pain, and current treatments aren't very effective. This can lead to limited movement and more health problems.
- Trial name
- NCT06228573
- Testing
- Yoga
- Where
- 3 sites in Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- McMaster University
Knee Osteoarthritis
Pain Informed Movement for People With Knee Osteoarthritis
The goal of this clinical trial is to compare a pain informed movement program to standard neuromuscular exercise in people with knee osteoarthritis. The main question it aims to answer are: 1.
- Trial name
- NCT05730829
- Testing
- pain informed movement, standard neuromuscular exercise, Pain Neuroscience Education (PNE)
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- McMaster University
Chronic Pain, Back Pain
Assess the Effectiveness of Pulse RadioFrequency in Patients With Chronic Lumbar Radicular Pain
Pulsed RadioFrequency (PRF) is a relatively new technique derived from a well established and proven intervention, thermal radiofrequency (RF). Both procedures are used in the treatment of chronic pain.
- Trial name
- NCT01117870
- Testing
- Pulsed Radiofrequency
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- McMaster University
Older Adults, Older Adults, Balance
AI-Adaptive AR Training for Balance and Falls Prevention in Older Adults
Falls are a common problem in adults within the age of 55-80 years and can lead to injury and loss of independence. This study is testing a new type of balance training using augmented reality (AR).
- Trial name
- NCT07781995
- Testing
- AI-Enhanced Augmented Reality Balance and Mobility Training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Postpartum Depression, Postpartum Anxiety
Online 1-Day CBT-Based Workshops for Preventing Postpartum Depression
To conduct a randomized controlled trial (N=408) examining the impact of an online cognitive behavioural therapy (CBT)-based workshop on rates of postpartum depression (i.e., EPDS scores at 2-months postpartum) when added to…
- Trial name
- NCT05753176
- Testing
- Online 1-Day Cognitive Behavioural Therapy-Based Workshop
- Where
- Canada
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- McMaster University
Perinatal Depression, Fathers
Group CBT for Paternal Perinatal Depression
The purpose of the proposed study is to determine the effectiveness of an online, 9-week group cognitive behavioural therapy (CBT) intervention for paternal perinatal depression (PND) in fathers and fathers-to-be.
- Trial name
- NCT07758036
- Testing
- Cognitive Behavioral Therapy for Paternal Perinatal Depression
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- McMaster University
Posttraumatic Stress Disorder
Investigating a Novel Sensory-based Program for Veterans With PTSD
SENSE-PTSD is an randomized controlled trial (RCT) which will evaluate the feasibility and efficacy of a novel, sensory-based psychoeducational program for improving psychological, functional, sensory, and cognitive outcomes in…
- Trial name
- SENSE-PTSD (NCT05766241)
- Testing
- Sensory Strategies Training
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- McMaster University
Monkeypox
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
- Trial name
- SMART (NCT05745987)
- Testing
- Bavarian Nordic smallpox vaccine, Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- 10 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pouchitis
Fecal Microbiota Transplantation for Pouchitis
This is a randomized double-blind placebo controlled trial involving a single centre (McMaster University) recruiting patients from Hamilton, ON and the surrounding regions, to evaluate whether fecal microbiota transplantation…
- Trial name
- NCT03545386
- Testing
- Fecal microbiota transplantation
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- McMaster University
Arthroscopic Shoulder Surgery
Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Arthroscopic Shoulder Surgery
Arthroscopic shoulder surgery is a common and minimally invasive procedure utilized for different shoulder pathologies, but it is often associated with moderate to severe postoperative pain that may interfere with patients'…
- Trial name
- NCT03691922
- Testing
- Erector Spinae Plane (ESP) Block, Periarticular Infiltration (PAI)
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- McMaster University
Post Surgical Pain
USFIB at the Inguinal Ligament for Total Hip Arthroplasty
Hip replacement surgery is one of the most common elective surgeries in Canada and with this surgery, there is considerable pain after the operation.
- Trial name
- NCT01911949
- Testing
- Single shot femoral nerve block
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Respiratory Depression
Vital Sign Monitoring With Continuous Pulse Oximetry and Wireless Clinician Notification After Surgery
Patients are at risk of respiratory depression after having surgery. The medications that patients are treated with to control their pain can impair their breathing and this can progress to respiratory and cardiac arrest and even…
- Trial name
- VIGILANCE (NCT02907255)
- Testing
- Oximetry monitor
- Where
- Canada
- Volunteers
- 2,512 people
- Sponsor
- McMaster University
Post-operative Pain
Ultrasound Guided Erector Spinae Plane Block in Patients Undergoing VATS Lobectomy
This study will compare ESP block plus patient-controlled analgesia (PCA) to intercostal nerve block plus PCA as post-operative pain control for patients having video-assisted thorascopic surgeries.
- Trial name
- NCT03176667
- Testing
- Ultrasound guided erector spinae plane block, Intercostal block
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Influenza (Healthy Volunteers)
SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial)
The flu is a health risk for Canadians. It causes up to 15,000 hospitalizations every year and is one of the top 10 causes of death. Getting a flu vaccine is the best way to prevent the flu and any severe complications.
- Trial name
- SAFE (NCT07739719)
- Testing
- LAIV FLUMIST
- Where
- Canada
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- McMaster University
Lung Cancer, Non Small Cell Lung Cancer
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer
Lung cancer is the leading cause of annual cancer deaths globally, more than breast, prostate, and colon cancers combined. The staging of chest lymph nodes (LNs) is a crucial step in the lung cancer diagnostic pathway because it…
- Trial name
- NodeAI (NCT06540196)
- Testing
- NodeAI, Surgeon
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Crohns Disease
Protease Regulation and Impact of Sodium as Mechanisms of Inflammation in IBD
The study looks at how eating salt affects gut health in people with Crohn's disease. The aim of the study is to find out whether eating more salt increases the breakdown of proteins in the gut and if this makes inflammation and…
- Trial name
- PRISM-IBD (NCT07169123)
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University