Clinical trials: sponsored by Poitiers University Hospital
Development of the Virtual Biopsy, Tumor Grade
Virtual Biopsy Development to Identify Patient's Glioma Grade at the CHU of Poitiers Using Magnetic Resonance Imaging
Glioma is a tumor of the central nervous system. These lesions are sorted with the WHO ranking regarding the tumoral oncotype. The tumoral MRI assessment is the first step before any medical decision.
- Conditions
- Development of the Virtual Biopsy, Tumor Grade, Artificial Intelligence Algorithms, Clinical
- Trial name
- MR3TGLIOBIOPSY (NCT04313140)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital
Multiple Sclerosis, Magnetic Resonance Spectroscopy
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify.
- Trial name
- NCT05491031
- Testing
- magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma, Myeloma Multiple
Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma
Isatuximab was developed on a sub-cutaneous (SC) administration format. SC administration is expected to be more convenient for the patient, with a much shorter duration of administration compared to the currently approved IV…
- Conditions
- Multiple Myeloma, Myeloma Multiple, Myeloma
- Trial name
- NCT05889221
- Testing
- Drug and medical device
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Poitiers University Hospital
Tyrosine Kinase Inhibitors, Chronic Myeloid Leukemia
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
Tyrosine kinase inhibitors (TKI) have revolutionized the management and prognosis of chronic myeloid leukemia (CML). Daily treatment with TKI, which is necessary due to lack of cure, is frequently associated with moderate…
- Trial name
- NCT05753384
- Testing
- treatment of TKI in CML
- Where
- 20 sites in France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Elderly, Emergency Departments
Prognostic Factors of Hospitalization for Patients Aged 75 and Over in Emergency Department in France - Monocentric Retrospective Cohort Study
A geriatric patient is defined as a patient aged 75 and over who meets certain medical or social vulnerability criteria and is characterised by coexisting physical and/or psychological dependence.
- Conditions
- Elderly, Emergency Departments, Prognostic Factors, Hospitalizations
- Trial name
- PROFACTHOS (NCT07475442)
- Where
- France
- Volunteers
- 967 people
- Sponsor
- Poitiers University Hospital
Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension
Efficacy and Tolerance of Treatment With Bevacizumab for Severe Liver Involvement With High Cardiac Output in Hereditary Hemorrhagic Telangiectasia Within the French Hereditary Hemorrhagic Telangiectasia Network
High cardiac output secondary to hepatic arteriovenous malformations may be isolated or associated with left heart failure with post-capillary pulmonary hypertension.
- Conditions
- Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension, Bevacizumab
- Trial name
- BevaHHearT (NCT07445347)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Poitiers University Hospital
Failed Back Surgery Syndrome, Chronic Pain
Study on Failed Back Surgery Syndrome Pathway Optimization: A Focus on Patient Identification, Chronicization Factors and Outcome Predictors
This pilot study is part of a global project that aims to better define and understand features of FBSS/POPS "post-operative persistent syndrome patients (shortened as "FBSS" in the following project).
- Trial name
- PREDIBACK (NCT02964130)
- Testing
- No name
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Stroke, Equinovarus Foot
Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke
CRYOSTROKE study is designed : to compare the efficacy and safety of percutaneous CryoNeurotomie (CN) versus surgical neurotomy (SN) on spasticity, 90 days after intervention, in post-stroke patients presenting with spastic…
- Conditions
- Stroke, Equinovarus Foot, Refractory Lower Limb Spasticity
- Trial name
- CRYOSTROKE (NCT06726434)
- Testing
- Surgical neurotomy (SN), Cryoneurotomy (CN)
- Where
- 7 sites in France
- Volunteers
- 114 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma (MM)
CAR-T Immunomonitoring in Multiple Myeloma (CART I5M)
Multiple myeloma patients can be treated with cell therapy, which uses some of their own modified white blood cells (T lymphocytes) to target a protein (BCMA, or B-cell maturation antigen) found on the surface of the myeloma…
- Trial name
- CART I5M (NCT07342179)
- Testing
- Additional Bone Marrow cells and blood sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Breast Cancer, Endocrine Disruptors
Confirmation of the Link Between Endocrine Disruptors Exposure and Breast Cancer and Identification of Biological Response Biomarkers
A wide variety of chemicals are constantly being introduced in our environment. The toxicological consequences related to the exposure to these compounds and their impact on public health ar of growing concern.
- Conditions
- Breast Cancer, Endocrine Disruptors, Metabolomics, Breast Lesions
- Trial name
- EXPOSAL (NCT07411651)
- Testing
- Collection of biological and clinical data
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Poitiers University Hospital
Chronic Neuropathic Pain
Evaluation of the Efficacy of STNS With FAST and MULTIWAVE in Patients With Refractory Chronic Neuropathic Pain
The goal of the study is to demonstrate Spinal Transforaminal NeuroStimulation effectiveness with FAST and other waveforms / combinations to relief neuropathic peripheral pain in chronic neuropathic pain patients, at low risk and…
- Trial name
- FORASTIM (NCT07154056)
- Testing
- Lead(s) and Implantable Pulse Generator implantation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Poitiers University Hospital
Nicotine Replacement Therapy, Healthcare Professionals
The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.
Tobacco is the leading preventable cause of death and disease worldwide. The health benefits of quitting smoking are well-documented. Healthcare professionals play a key role in the fight against smoking.
- Conditions
- Nicotine Replacement Therapy, Healthcare Professionals, Tobacco Craving, Tabacco Cessation
- Trial name
- MUSICAT (NCT07412717)
- Testing
- Nicotine Replacement Therapy (NRT, nicotine patch), Music intervention, Biological collection
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Acute Respiratory Distress Syndrome (ARDS)
Accuracy of the Chest Radiograph for the Diagnosis of Acute Respiratory Distress Syndrome
The presence of bilateral lung infiltrates on chest imaging is a mandatory criterion for the diagnosis of acute respiratory distress syndrome (ARDS).
- Trial name
- CT 4 ARDS (NCT07400445)
- Where
- France
- Volunteers
- 277 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma, Myeloma
Multicenter Open Label Phase 3 Study of Isatuximab Plus Lenalidomide and Dexamethasone With/Without Bortezomib in the Treatment of Newly Diagnosed Non Frail Transplant Ineligible Multiple Myeloma Elderly Patients (≥ 65; < 80 Years).
Overall the issue of patients above 65-70 years of age being that it is impossible for most of them to undergo an intensive treatment like autologous stem cell transplant with little prospect of debulking effectively the bone…
- Trial name
- NCT04751877
- Testing
- Isatuximab, Lenalidomide, Bortezomib
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Poitiers University Hospital
Urinary Incontinence
Efficacy of a Video-Based Educational Program on Female Urinary Incontinence
The aim of this clinical trial is to assess the effectiveness of a 4-week video-based education program in enhancing urinary continence among women with urinary incontinence referred for pelvic floor rehabilitation The main…
- Trial name
- EVRP (NCT07105150)
- Testing
- video-based education program, written information
- Where
- 12 sites in France
- Volunteers
- 144 people
- Sponsor
- Poitiers University Hospital
Breast Cancer, Pancreatic Cancer
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
The goal of this clinical trial is to develop a new cancer diagnostic and prognostic tool based on the dynamic and non-invasive detection of an exogenous volatile molecule, i.e., ethanol, from patients' samples.
- Conditions
- Breast Cancer, Pancreatic Cancer, Pulmonary Cancer, Volatile Organic Compound
- Trial name
- B-GLUCANCER2 (NCT07236177)
- Testing
- blood plasma sample, blood sampling
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Mild Cognitive Impairment, Persistent Atrial Fibrillation
EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment.
- Trial name
- NCT05790707
- Testing
- Atrial fibrillation ablation + antiarrhythmic drugs, Antiarrhythmic drug
- Where
- 8 sites in France
- Volunteers
- 120 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Neuropathic Pain
International Neuromodulation Registry
The design and execution of the International Neuromodulation Society (INS) registry has been developed with the objective of assessing the efficacy and safety of Spinal Cord Stimulation and other neuromodulation therapies using…
- Trial name
- NCT07354243
- Testing
- Neuromodulation therapies
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Pediatrics, Virus Diseases in Children
Evaluation of the Diagnostic Capabilities of Saliva Samples From Pediatric Patients, Promoting Active Involvement of the Individuals Concerned and Their Families.
The management of respiratory infections accounts for a large proportion of winter activity in paediatric wards. The main pathologies are bronchiolitis, affecting infants under the age of 2.
- Trial name
- Presap (NCT07350291)
- Testing
- The aim is to compare the effectiveness of virological and bacterial detection between two sampling methods
- Volunteers
- 502 people
- Sponsor
- Poitiers University Hospital