Clinical trials: sponsored by Radboud University Medical Center
Cardiac Arrest, Cardiopulmonary Arrest
Lowlands Saves Lives: A Randomized Trial Comparing CPR-quality Between Face-to-face vs. Lifesaver VR Training
The objective of the Lowlands Saves Lives trial is to compare the quality of cardiopulmonary resuscitation (CPR) between face-to-face versus Lifesaver Virtual Reality smartphone application trained participants using a randomized…
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT04013633
- Testing
- Lifesaver virtual reality training, Face-to-face training
- Where
- Netherlands
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Large Bowel Polyp
Dutch National Prospective EMR Cohort
A Prospective Study: Longterm Follow Up until S2 (2nd surveillance) at 18 months after EMR for Large Flat/Sessile Colonic Polyps.
- Trial name
- DN-PEC (NCT03545061)
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Cancer, Malnutrition
The Impact of a Home Delivered Meal Service in Cancer Patients During Chemotherapy
Cancer patients receiving treatment such as chemotherapy experience a variety of symptoms that interfere with their appetite and their ability to eat and enjoy meals.
- Trial name
- NCT03382171
- Testing
- FoodforCare at home
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- Radboud University Medical Center
Delirium
The Impact of Nursing Delirium Preventive Interventions in the Intensive Care Unit
Delirium is a common disorder in Intensive Care Unit (ICU) patients and is associated with serious short- and long-term consequences.
- Trial name
- UNDERPIN-ICU (NCT03002701)
- Testing
- UNDERPIN-ICU program
- Where
- 11 sites in Netherlands
- Volunteers
- 1,750 people
- Sponsor
- Radboud University Medical Center
Preeclampsia, Cardiovascular Risk Factor
Blood Pressure After PREeclampsia/HELLP by SELF Monitoring Study
RATIONALE: Women with a previous history of preeclampsia (PE)/HELLP have a twofold higher risk of cardiovascular disease (CVD) and a fourfold increased risk to develop hypertension at a relative young age.
- Conditions
- Preeclampsia, Cardiovascular Risk Factor, Cardiovascular Diseases, Hypertension
- Trial name
- BP-PRESELF (NCT03228082)
- Testing
- Home Blood Pressure Monitoring (HBPM)
- Where
- 6 sites in Germany, Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Medication Safety, Patient Safety
Effects of Self-administration of Medication During Hospitalization on Medication Safety, Adherence, and Patient Satisfaction in Dutch Hospitals
During hospitalization, medication administration errors (MAEs) occur daily in health care and can lead to serious harm. Improvement of medication safety is a major concern to policymakers and health care workers.
- Conditions
- Medication Safety, Patient Safety, Patient Empowerment
- Trial name
- MIEB (NCT03728855)
- Testing
- Self-administration of medication (SAM)
- Where
- 8 sites in Netherlands
- Volunteers
- 193 people
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum, Gametocytes
Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2
This is a single-center, open label study. The primary aim of this project is to develop a controlled human malaria infection transmission model ("CHMI-trans") or "challenge model" to evaluate the capacity of vaccines, biologics…
- Conditions
- Malaria,Falciparum, Gametocytes, Controlled Human Malaria Infection, Transmission
- Trial name
- CHMI-trans2 (NCT03454048)
- Testing
- Piperaquine (low dose), Piperaquine (high dose), Sulfadoxine pyrimethamine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Melanoma, Malignant, of Soft Parts
Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy
Rationale: The combination of ipilimumab and nivolumab induces relatively high response rates and promising response depth in late stage melanoma.
- Trial name
- COWBOY (NCT02968303)
- Testing
- Vemurafenib and Cobimetinib
- Where
- 13 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
COVID-19
Reducing COVID-19 Related Hospital Admission in Elderly by BCG Vaccination
Bacillus Calmette-Guérin (BCG) vaccine not only protects against tuberculosis, but has also been shown to induce protection against various infections with a viral aetiology, leading to significant reductions in morbidity and…
- Trial name
- NCT04417335
- Testing
- BCG vaccine
- Where
- 2 sites in Netherlands
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Breastcancer
Minimal Invasive Breast Cancer Excision Using the Breast Lesion Excision System Under Ultrasound Guidance
This study will assess whether it is feasible to remove small breast cancers completely using the Breast Lesion Excision System under Ultrasound guidance.
- Trial name
- BLES (NCT02975128)
- Testing
- BLES system and conventional lumpectomy
- Where
- 2 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- Radboud University Medical Center
Laparoscopic Surgery, Pneumoperitoneum
The Effect of Intra-abdominal Pressure on Peritoneal Perfusion During Laparoscopic Colorectal Surgery
Peritoneal perfusion during laparoscopic surgery is quantified by video recording after intravenous injection of indocyanine green at a pneumoperitoneum pressure of 8, 12 and 16 mmHg.
- Trial name
- PERFUSION (NCT03928171)
- Testing
- Intra-abdominal pressure during laparoscopy
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Early Pregnancy Failure
Comparing Two Medical Treatments for Early Pregnancy Failure.
This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage.
- Trial name
- Triple M (NCT03212352)
- Testing
- Mifepristone, Misoprostol
- Where
- 13 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer, MRI
MR-guided Focal Laser Ablation of the Prostate
Purpose of the investigators study is to determine the short and medium term histological cancer control of focal therapy using MR-guided focal laser ablation therapy in the treatment of localised prostate cancer.
- Conditions
- Prostate Cancer, MRI, Focal Laser Ablation
- Trial name
- NCT02200809
- Testing
- MR-guided focal laser ablation
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1, Hypoglycemia
Effect of Dapagliflozin on IAH in T1DM
Approximately 25% of patients with type 1 diabetes have lost the capacity to timely detect hypoglycaemia, a condition referred to as impaired awareness of hypoglycaemia (IAH) that causes a six-fold higher risk of severe…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT03556033
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Acute Myeloid Leukemia (AML)
10-day Decitabine, Fludarabine and 2 Gray TBI as Conditioning Strategy for Poor and Very Poor Risk AML in CR1
This study examines whether the addition of decitabine to the standard Flu/TBI conditioning regimen prior to allogeneic stem cell transplantation in poor and very poor risk AML patients, reduces the risk of recurrence of the…
- Trial name
- NCT02252107
- Testing
- decitabine
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 46 people
- Sponsor
- Radboud University Medical Center
Diabetes type1
Current State of Impaired Awareness of Hypoglycaemia in People With Type 1 Diabetes
Rationale: Hypoglycaemia is the most frequent complication of insulin treatment in individuals with type 1 diabetes and a limiting factor for achieving optimal glycaemic control.
- Trial name
- NCT04311021
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Visual Acuity at Near, Accuracy of Accommodation
The Effect of Bifocals in Children With Down Syndrome
Visual acuity at near improves in children with Down syndrome using bifocals
- Conditions
- Visual Acuity at Near, Accuracy of Accommodation, Prevention of Strabismus, Task Readiness
- Trial name
- NCT02241356
- Testing
- bifocals, single vision glasses
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Polyps
e-Nose and Colorectal Cancer
Colorectal cancer (CRC) is the third most common new cancer diagnosis and a major cause of morbidity and mortality throughout the world.
- Trial name
- NCT03488537
- Testing
- AeonoseTM
- Where
- Netherlands
- Volunteers
- 511 people
- Sponsor
- Radboud University Medical Center
Cardiotoxicity, Breast Cancer
Early Detection of Cardiac Damage With CMR in Women With Breast Cancer
With this study the investigators will assess early cardiac damage by means of Global Longitudinal Strain (GLS) in newly diagnosed breast cancer (BC) patients treated with anthracycline-based chemotherapy, and to investigate…
- Conditions
- Cardiotoxicity, Breast Cancer, Chemotherapy Induced Systolic Dysfunction
- Trial name
- EARLY-CATCH (NCT04046315)
- Testing
- CMR
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Polyps of Colon
Detection of Colorectal Cancer in Patients With a Positive Fecal Immunochemical Test Using an Electronic Nose Device (AeoNoseTM)
The present study aims to investigate the diagnostic accuracy of exhaled breath analysis with the Aeonose (the eNose Company, Zutphen, the Netherlands) to distinguish the breath of patients suspected for CRC (based on a positive…
- Trial name
- NCT03346005
- Testing
- Aeonose
- Where
- Netherlands
- Volunteers
- 3,345 people
- Sponsor
- Radboud University Medical Center