Clinical trials: sponsored by Radboud University Medical Center
Mild Cognitive Impairment
The Effects of an Extensive Exercise Program on the Progression of Mild Cognitive Impairment
Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by…
- Trial name
- NeuroExercise (NCT02913053)
- Testing
- Aerobic exercise, Non-aerobic exercise
- Where
- 3 sites in Germany, Ireland and 1 more
- Volunteers
- 183 people
- Sponsor
- Radboud University Medical Center
Prostatic Neoplasms, Immunotherapy
Natural Dendritic Cells for Immunotherapy of Chemo-naive Metastatic Castration-resistant Prostate Cancer Patients
Prostate cancer is the only type of cancer in which conventional dendritic cells (DC) treatment has a beneficial effect on the overall survival.
- Conditions
- Prostatic Neoplasms, Immunotherapy, Dendritic Cells, Vaccines
- Trial name
- NCT02692976
- Testing
- mDC vaccination, pDC vaccination, mDC and pDC vaccination
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center
Surgery-Induced Tissue Adhesion, Surgical Adhesions
National Snapshot Study Adhesive Small Bowel Obstruction (ASBO)
Over 63-90% of patients develop peritoneal adhesions after abdominal or pelvic surgery. Which makes it the most common complication after abdominal or pelvic surgery.
- Conditions
- Surgery-Induced Tissue Adhesion, Surgical Adhesions, Adhesion, Tissue
- Trial name
- NCT03786159
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Radboud University Medical Center
Anastomotic Leak Rectum, Rectal Cancer
Treatment of Anastomotic Leakage After Rectal Cancer Resection
The TENTACLE: Rectum study is a multinational retrospective cohort study that includes patients with anastomotic leakage after rectal cancer resection.
- Trial name
- TENTACLE:R (NCT04127734)
- Testing
- The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated
- Volunteers
- 1,246 people
- Sponsor
- Radboud University Medical Center
Tissue and Organ Procurement
Prediction on Time to Death in Potential Controlled Donation After Circulatory Death (cDCD) Donors (DCD III Study)
A considerable number of potential cDCD donors do not convert into actual organ donors because circulatory arrest does not occur within the predefined timeframe of warm ischemia after withdrawal of life-sustaining treatment.
- Trial name
- DCDIII (NCT04123275)
- Testing
- No intervention wil be done. Patient characteristics and the standard care before and after withdrawal of life-sustaining treatment in all potential cDCD donors, will be studied. .
- Where
- 6 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Nemaline Myopathy Type 6, Myotonic Dystrophy Type 2
Muscle Relaxation in Myopathies With Positive Muscle Phenomena
The aim of this study is to quantify muscle relaxation properties of the finger flexor muscles in patients with different myopathies.
- Conditions
- Nemaline Myopathy Type 6, Myotonic Dystrophy Type 2, McArdle Disease
- Trial name
- NCT03211923
- Testing
- Transcranial magnetic stimulation (TMS)
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Carcinoma, Basal Cell
Reflectance Confocal Microscopy in Basal Cell Carcinoma
Skin cancer is the most common cancer and its incidence is increasing rapidly. The rising number of skin cancer may result in long waiting lists for consultation at departments for dermatological care and in increasing health…
- Trial name
- NCT02623101
- Testing
- Reflectance confocal microscopy, Punch biopsy, Surgical excision
- Where
- 3 sites in Netherlands
- Volunteers
- 288 people
- Sponsor
- Radboud University Medical Center
Neuromuscular Block, Renal Transplant Donor of Left Kidney
Deep Versus Moderate Muscle Relaxation During Laparoscopic Donor Nephrectomy in Enhancing Postoperative Recovery
Postoperative recovery after live donor nephrectomy (LDN) is largely determined by the consequences of postoperative pain and analgesia consumptions.
- Conditions
- Neuromuscular Block, Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney, Surgery
- Trial name
- RELAX (NCT02838134)
- Testing
- Rocuronium, No additional Rocuronium
- Where
- 2 sites in Netherlands
- Volunteers
- 101 people
- Sponsor
- Radboud University Medical Center
Malignant Neoplasm of Stomach, Carcinoma, Diffuse Type
Screening for Familial Gastric Cancer in First Degree Relatives
The purpose of this study is to determine whether staining of the gastric mucosa increases the number of detected (pre)malignant foci of intestinal and diffuse type gastric cancer, in first degree relatives of individuals with…
- Conditions
- Malignant Neoplasm of Stomach, Carcinoma, Diffuse Type, Intestinal Type Adenocarcinoma of Stomach, Relative (Related Person)
- Trial name
- FamGaCan (NCT01727908)
- Testing
- Endoscopy with staining of the mucosa
- Where
- Netherlands
- Volunteers
- 79 people
- Sponsor
- Radboud University Medical Center
Colon Cancer, Aging
PreColo Practice Variation
This study will answer the question what the practice variation is (in terms of efficiency) in primary colon surgery on patients of 75 years and above related to the application of different modalities of prehabilitation across…
- Conditions
- Colon Cancer, Aging, Postoperative Complications
- Trial name
- NCT03682133
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Peritoneal Carcinomatosis, Colorectal Cancer
Multi-modality Imaging in Peritoneal Carcinomatosis of Colorectal Origin
Intraoperative tumor localization and resection can be enhanced using intraoperative fluorescence imaging and radiodetection. Labetuzumab specifically recognizes CEA which is is expressed on > 95% of colorectal cancers..
- Conditions
- Peritoneal Carcinomatosis, Colorectal Cancer, Carcinoma, Neoplasms
- Trial name
- MMIPC (NCT03699332)
- Testing
- Indium-111-DOTA-Labetuzumab-IRDye800CW injection, SPECT/CT scan, CRS extended with dual-modality imaging
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Metastatic Castration Resistant Prostate Cancer
Optimizing Abiraterone Therapy
The purpose of this study is to explore whether early abiraterone exposure is related to treatment response in patients with metastatic castration resistant prostate cancer.
- Trial name
- OPTIMUM (NCT02426333)
- Testing
- Abiraterone Acetate
- Where
- 3 sites in Netherlands
- Volunteers
- 56 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Surgery
Developing and Testing an Implementation Strategy to Improve Perioperative Diabetes Care
Optimising glycaemic control during hospital stay reduces the rate of infections, length of stay and mortality, in particular in surgical patients.
- Trial name
- NCT01610674
- Testing
- Tailored improvement strategy
- Where
- Netherlands
- Volunteers
- 811 people
- Sponsor
- Radboud University Medical Center
Postoperative Pain
Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine
Despite current available analgesic drugs, post-surgical pain management remains challenging. A potential new target for analgesic drugs are group-II metabotropic glutamate receptors subtypes (mGlu2 and mGlu3 receptors), since…
- Trial name
- NCT03354572
- Testing
- Acetyl cysteine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Endotoxemia
The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Rationale: The last years, research focus has moved to immunostimulatory agents in order to restore or increase the functionality of the immune system during sepsis-induced immunoparalysis.
- Trial name
- SALYCENDO (NCT02922673)
- Testing
- Aspirin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dyspepsia, Indigestion
Trial to Reduce Inappropriate Oesophagogastroduodenoscopies for Dyspepsia
Indigestion or dyspepsia is highly prevalent worldwide. Often these symptoms are of benign nature and subside without treatment, or with lifestyle interventions like dietary modifications.
- Trial name
- TRIODe (NCT03205319)
- Testing
- e-learning
- Where
- 5 sites in Netherlands
- Volunteers
- 119 people
- Sponsor
- Radboud University Medical Center
Innate Immune Response, Immune Tolerance
The Effects of Preceding LPS Administration on the Fluenz-induced Immune Response
To evaluate the bacterial-viral interactions between LPS and Fluenz as a model for sepsis (bacterial) and Influenza (viral) infections which are common and associated with high mortality rates in the ICU.
- Trial name
- LPS-Fluenz (NCT02642237)
- Testing
- Fluenz, LPS
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Acute Kidney Injury, Critically Ill Children
Iohexol for Measuring Renal Function
Approximately 25-35% of all children admitted to the paediatric intensive care unit (PICU) or neonatal intensive care unit (NICU) will develop Acute Kidney Injury (AKI) during the first seven days after admission.
- Trial name
- HERO (NCT03946345)
- Testing
- Iohexol Inj 300 MG/ML
- Where
- Netherlands
- Volunteers
- 105 people
- Sponsor
- Radboud University Medical Center
Chronic Pain, Tissue Adhesion
Laparoscopic Adhesiolysis for Chronic Abdominal Pain Revisited
Chronic abdominal and pelvic pain is a common complaint following peritoneal surgery, affecting 20-40% of patients. Adhesions account for 60% of chronic postoperative pain cases, suggesting that adhesiolysis can play an important…
- Trial name
- NCT02983916
- Testing
- Adhesiolysis
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Endometrial Cancer
FESPET Study: Female EStrogen recePtor in Endometrial Cancer Treatment
Endometrial cancer is the most common gynecological malignancy in the western world and its incidence is expected to increase in the coming years due to obesity.
- Trial name
- FESPET (NCT03489473)
- Testing
- 18F-FES PET CT scan
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center