Clinical trials: sponsored by Radboud University Medical Center
Type 1 Diabetes Mellitus, Hypoglycemia Unawareness
The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
Iatrogenic hypoglycemia is the most frequent acute complication of insulin therapy in people with type 1 diabetes (T1DM). Recurrent hypoglycemic events initiate a process of habituation, characterized by suppression of…
- Trial name
- NCT02308293
- Testing
- High intensity exercise, Lay down comfortably
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
Effects of Vasopressors on Immune Response
Noradrenaline is a catecholamine and the cornerstone treatment for the improvement of hemodynamic parameters in septic shock. Catecholamines exert profound immunomodulatory effects.
- Trial name
- NCT02675868
- Testing
- Norepinephrine, Phenylephrine, Vasopressins
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Central Spinal Cord Syndrome
Comparing Surgical Decompression Versus Conservative Treatment in Incomplete Spinal Cord Injury
Traumatic Central Cord Syndrome (TCCS) was until recent recognized as a separate clinical entity. The most characteristic feature is the disproportionate more motor impairment of the arms and especially the hands than the legs…
- Trial name
- COSMIC (NCT01367405)
- Testing
- Surgical decompression, Conservative treatment
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Radboud University Medical Center
Adrenal Insufficiency
Inhalation/Nasal Corticosteroids and Prevalence of Hypothalamic-pituitary-adrenal (HPA) Axis Suppression in Human Immunodeficiency Virus (HIV)-Patients
Rationale: Case reports describe suppression of the hypothalamic-pituitary-adrenal (HPA) axis caused by local corticosteroids, most often with inhalation corticosteroids. The exact prevalence is not known.
- Trial name
- Incorporate (NCT02501486)
- Testing
- ACTH stimulation test
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Whooping Cough
Influence of BCG on TDaP-IPV Vaccination
This study has three purposes: To investigate whether the immune response to pertussis is increased when TDaP-IPV is given together with BCG vaccine, compared to when it is given alone.
- Trial name
- NCT02771782
- Testing
- BCG vaccine (SSI), TDaP-IPV vaccine
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Ovarian Neoplasms, Immune Tolerance
Intra-peritoneal Chemotherapy in Ovarian Cancer
Ovarian cancer is the third most common gynecological malignancy worldwide. Because of late, aspecific symptoms, the disease is usually diagnosed at an advanced stage.
- Conditions
- Ovarian Neoplasms, Immune Tolerance, Neoplasms, Effects of Chemotherapy
- Trial name
- NCT02861872
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Innate Immune Response
γ-irradiated BCG to Train Innate Immunity
Rationale: The live attenuated Bacillus Calmette-Guerin (BCG) vaccine protects against extrapulmonary infection with Mycobacterium tuberculosis and leprosy.
- Trial name
- NCT02259608
- Testing
- BCG vaccine SSI
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia, Systemic Inflammatory Response
PK/PD of EA-230 During Endotoxemia
EA-230 is a newly developed synthetic compound with anti-inflammatory properties. Pre-clinical data indicate that EA-230 may be a valuable treatment for systemic inflammation resulting from a variety of causes such as surgery…
- Trial name
- NCT02629874
- Testing
- EA-230, Endotoxin
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ovarian Neoplasms, Quality of Life
Improving Quality of Care for Patients With Recurrent Ovarian Cancer
Ovarian cancer is a major cause of cancer related death among women. The disease is usually advanced at diagnosis, because specialist referral is delayed due to vague nature of presenting symptoms.
- Trial name
- NCT02809339
- Testing
- Questionnaires
- Volunteers
- 360 people
- Sponsor
- Radboud University Medical Center
Chronic Fatigue Syndrome
Cytokine Inhibition in Chronic Fatigue Syndrome Patients
Rationale: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective.
- Trial name
- CiCFS (NCT02108210)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Premature Birth, Extremely Premature Infants
Prenatal Counseling in Extreme Prematurity: Professionals' View
This study is part of the PreCo study, evaluating Dutch care in (imminent) extreme preterm birth including current and preferred counseling, barriers and facilitators for preferred counseling from both obstetricians and…
- Trial name
- PreCo-profs (NCT02782650)
- Testing
- survey and interview
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Extreme Prematurity, Complications
Prenatal Counseling in Extreme Prematurity: Parents' View
This study is part of the PreCo study, evaluating Dutch care in (imminent) extreme preterm birth including current and preferred counseling, barriers and facilitators for preferred counseling from both obstetricians and…
- Trial name
- PreCo-parents (NCT02782637)
- Testing
- survey and interview
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus
ET-blockade and Exercise-induced Vascular Adaptations in T2DM
The purpose of this study is to establish the effect of ET blockade on vascular adaptations during an 8-week exercise program in subjects with T2DM.
- Trial name
- NCT01779609
- Testing
- Bosentan, Exercise
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus
ET-blockade and Exercise Induced Blood Flow in T2DM
The purpose of this study is to establish the effect of ET blockade on the acute exercise induced blood flow and endothelial function in subjects with T2DM.
- Trial name
- NCT01779596
- Testing
- Bosentan
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Symptomatic Dominant Liver Cyst
Efficacy of Combining Pasireotide With Aspiration Sclerotherapy to Improve Volume Reduction of Hepatic Cysts
Liver cysts are fluid filled cavities located in the liver. They are present in 2-11% of the general population, typically not causing any symptoms or complications.
- Trial name
- Sclerocyst (NCT02048319)
- Testing
- Pasireotide LAR 60 mg, Aspiration sclerotherapy
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Radboud University Medical Center
Melanoma
Platin-based Chemotherapeutics to Enhance Dendritic Cell Vaccine Efficacy in Melanoma Patients
This is an exploratory study and the primary objective is the immunogenicity and feasibility of combined chemotherapy-DC vaccination. The secondary objectives are the toxicity and clinical efficacy.
- Trial name
- NCT02285413
- Testing
- DC vaccination, DC vaccination with cisplatinum
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Radboud University Medical Center
AMPD, Ischemic Tolerance
The Influence of the 34C>T Variant in the AMPD1 Gene Ischemic Tolerance
Previous epidemiological studies have shown that in cardiovascular patients, the 34C>T variant in the gene encoding for the enzyme Adenosine Mono Phosphate Deaminase (AMPD1) is associated with prolonged survival.
- Trial name
- NCT00319059
- Testing
- systemic administration of 99mTc-HYNIC-Annexin A5, 10 minutes of ischemic handgripping
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Atherosclerosis
Epigenetic Reprogramming of Monocytes in Patients With Coronary Atherosclerosis
In this study, the investigators will determine whether patients with documented atherosclerosis are characterized by specific epigenetic changes in circulating cells of the innate immune system, compared to patients without…
- Trial name
- NCT02393768
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Out-of-hours Care Services, Primary Healthcare
The Effect of Substitution of Out-of-hours Care From General Practitioners to Nurse Practitioners
The aim of this study is to explore the effects of substitution in out-of-hours primary care. In consecutive stages an extra General Practitioner (GP) is substituted by a Nurse Practitioner (NP) aiming at replacing 3 out of 4 GPs…
- Trial name
- NCT02407847
- Testing
- care provided by Nurse Practitioners
- Where
- Netherlands
- Volunteers
- 9,647 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center