Clinical trials: sponsored by Rennes University Hospital
Lung Diseases
Phenotypic Characterization of Alveolar Macrophages 2016 (Caract-Aires-2016)
The aim of the study is to investigate by flow cytometry the phenotype of alveolar macrophages (AMs) isolated from patients with non-infectious lung diseases.
- Trial name
- Caract-Aires (NCT03250897)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Neurological Diseases, Central Nervous System
Rapid Declarative Neocortical Declarative Learning in Aging and Memory Diseases (ANéRAVIMM)
Learning a person's name, new words, or simply remembering where the last conversation with a friend was held are examples of associative memory, frequently disturbed in brain pathologies, but also by aging.
- Trial name
- ANéRAVIMM (NCT04846764)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type
Intestinal Organoids
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell…
- Conditions
- Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type, Crohn Disease
- Trial name
- BIOÏDES (NCT05294107)
- Testing
- additional biopsies
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Alzheimer Disease, Early Onset
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
Patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD) may or may not develop Alzheimer's disease (AD) dementia.
- Trial name
- MIMA-P (NCT06099587)
- Testing
- high-resolution diffusion MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Liver Transplantation, Acute Kidney Injury
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver…
- Trial name
- HALT (NCT06535945)
- Testing
- Albumin administration
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Nursing Homes, Clinical Trial
MAÏA - MAintain the Level of Independence Through Alimentation
Malnutrition has serious consequences: increased risk of falls, hospitalization and mortality. Malnutrition may accompany or aggravate another geriatric syndrome.
- Conditions
- Nursing Homes, Clinical Trial, Food
- Trial name
- MAÏA (NCT05628155)
- Testing
- Oral diet including n-3 PUFA intake
- Where
- France
- Volunteers
- 315 people
- Sponsor
- Rennes University Hospital
Oocyte Retrieval, Local Anaesthesia
Assessment of the Influence of the Virtual Reality Headset on Pain and Anxiety During Oocyte Retrieval Under Local Anesthesia
Medically Assisted Reproduction provides help to infertile couples, single women and couples of women with a pregnancy project, and to women who wish to preserve their gametes.
- Conditions
- Oocyte Retrieval, Local Anaesthesia, Virtual Reality
- Trial name
- OVOREV (NCT05528497)
- Testing
- VR+
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Orthodontic Appliance
Comparison of the Effectiveness of Three Teaching Methods in Oral Hygiene in Adolescent Orthodontic Patients
Orthodontic appliances have been shown to interfere with oral hygiene maneuvers by providing many additional sites for formation and retention of biofilm.
- Trial name
- MAHO (NCT04444154)
- Testing
- Control group, Group with active participation, Group with video and quizz
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Parkinson's Disease
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP)
The aim of the study is to assess the use of the apomorphine pump in earlier stages of Parkinson' Disease (PD), when motor complications have just developed and before patients are significantly affected in their social and…
- Trial name
- EARLY-PUMP (NCT02864004)
- Testing
- Apomorphine, Best Medical Treatment
- Where
- 20 sites in France
- Volunteers
- 134 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
EMISEP : Early Spinal Cord Lesions and Late Disability in Relapsing Remitting Multiple Sclerosis Patients
The purpose of this study is to evaluate the prognostic value of early focal lesions and early diffuse lesions on ambulatory disability progression within 5 years after clinical onset.
- Trial name
- EMISEP (NCT02117375)
- Testing
- spinal cord MRI follow-up, clinical follow-up, brain MRI follow-up
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Pneumonia, Pneumocystis
Pneumocystis Pneumonia Diagnosis in HIV- Patients
Pneumocystis jirovecii pneumonia is a serious and frequent infection in immunocompromised patients, whose evolution is potentially fatal if untreated.
- Trial name
- PNEUMOQUANT (NCT02648256)
- Testing
- Polymerase Chain Reaction on Oropharyngeal rinse
- Where
- 3 sites in France
- Volunteers
- 408 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Impact Study of 2 Therapeutic Strategy for Aggressive Remitting Multiple Sclerosis
Cost-effectiveness study of 2 disease-modifying therapies (natalizumab versus mitoxantrone followed by immunomodulator) in the management of aggressive remitting multiple sclerosis
- Trial name
- IQUALYSEP (NCT01065727)
- Testing
- mitoxantrone - immunomodulator, natalizumab
- Where
- 2 sites in France
- Volunteers
- 144 people
- Sponsor
- Rennes University Hospital
Parkinson
Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information
The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals.
- Trial name
- EMOPHYSIO (NCT01537224)
- Testing
- Measure of the electrophysiological activity of the subthalamic nucleus
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Rennes University Hospital
Suicide
Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide
Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be…
- Trial name
- EMODES (NCT02901769)
- Testing
- fMRI
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Eschar
Feasibility Study - The Place of Surgical Management by Fatty Autograft in Patients With Healed Pelvic Eschar. Interest in Secondary Prevention.
Autografting of fat cells is widely used in plastic surgery in breast reconstruction, burn scars, unsightly scars etc. It is known that the autografting of fat cells not only makes it possible to bring adipocytes, and thus to…
- Trial name
- FATSCAR (NCT03669406)
- Testing
- Autograft fat
- Where
- France
- Sponsor
- Rennes University Hospital
Depression
Study Pilot - Hybrid EEG/fMRI Neurofeedback in Depressed Patients
Cognitive impairment is a common residual symptom after a depressive episode and expose patients to a risk of relapsing or therapeutic resistance.
- Trial name
- NEUROFEEDEP (NCT04450186)
- Testing
- EEG/fMRI neurofeedback
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Compare 2 Models of Midwifery Care in Maternity Care
Personalized Support Care in Alternative Midwifery Birth Units Versus Traditional Units in France : Effects on Perinatal Health and Outcomes
Most pregnancies and deliveries in France occur without complication. According to the 2016 Perinatal Survey, 2/3 of births are carried out by spontaneous vaginal delivery with midwife support in most cases.
- Trial name
- PhysioCare (NCT05483101)
- Testing
- Alternative birth units
- Where
- 3 sites in France
- Volunteers
- 597 people
- Sponsor
- Rennes University Hospital
Stroke Sequelae
Resume Walking by an Interactive Mobile Robot of Rehabilitation After Vascular Stroke (Cerebral Vascular Stroke) in Combination With Traditional Reeducation
The recovery of a balance and gait is a primary objective for geriatric, neurological or orthopedic rehabilitation. Since the 80s, many walking robots were proposed.
- Trial name
- ROBOK2 (NCT03686280)
- Testing
- Clinical evaluation, Intervention - with Robot, Intervention - without Robot
- Where
- 2 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Fecal Continence Disorders, Posterior Pelvic Static Disorders
Fecal Incontinence and Rectal Static Disorder
This study evaluate the rate of occurrence of fecal incontinence in patients who had surgery for posterior pelvic static disorder versus those with medical management.
- Trial name
- NATUROSTATIQ (NCT04566640)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Rennes University Hospital
Emergencies
Population Pharmacokinetics of Metronidazole in Neonates
The objective of NEOPOPI is to conduct a population pharmacokinetic study of metronidazole in neonates, in order to evaluate and optimize neonatal dose regimen.
- Trial name
- METROPOP (NCT04031183)
- Where
- 7 sites in France
- Volunteers
- 171 people
- Sponsor
- Rennes University Hospital