Clinical trials: sponsored by Rennes University Hospital
Genetic Hemochromatosis
Bone Status on Patients With Genetic Hemochromatosis: a 3 Years Descriptive and Evolutionary Study
The purpose of this study is to describe bone status on patients with genetic hemochromatosis, at diagnostic time and his evolution under treatment.
- Trial name
- FEROS (NCT01556360)
- Where
- 6 sites in France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Iron Metabolism Disorders
Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers
The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis.
- Trial name
- HEPEPO (NCT00687518)
- Testing
- Erythropoietin
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Anesthesia
Pharmacokinetic Study of Intravenous Lidocaine in Young and Elderly Patients
Aging is accompanied by a gradual alteration in the functional reserve of several organs and a change in body composition that can affect the pharmacokinetics, response, and safety profile of medications.
- Trial name
- ElderLIDO_1 (NCT06795100)
- Testing
- Pre-inclusion, Inclusion, Lidocaine
- Where
- 2 sites in France
- Volunteers
- 67 people
- Sponsor
- Rennes University Hospital
Haemochromatosis
Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis
Patients in maintenance treatment for HFE hemochromatosis since at least one year will be included in a two year study period and randomized in two groups experimental and control group.
- Trial name
- Quali-SAT (NCT04779593)
- Testing
- Clinical examination, SF36 questionnaire, AIMS2_SF questionnaire
- Where
- 12 sites in France
- Volunteers
- 239 people
- Sponsor
- Rennes University Hospital
Hypertrophic Cardiomyopathy (HCM)
LA-HCM Study : Rivaroxaban for Antithrombotic Prevention in Hypertrophic Cardiomyopathy Patients With Abnormal Left Atrial Strain.
Hypertrophic cardiomyopathy (HCM) is a common (> 1/500 in the general adult population) genetically transmitted disease impacting markedly patients' lives from the early ages to the latest.
- Trial name
- LA-HCM (NCT07202897)
- Testing
- Anticoagulant treatment Rivaroxaban, Best medical therapy
- Where
- 17 sites in France
- Volunteers
- 532 people
- Sponsor
- Rennes University Hospital
Subarachnoid Hemorrhage
Searching a Dysfunction of Corticotropic & Thyrotropin Axis During the Acute Phase of a Subarachnoid Hemorrhage Secondary to Spontaneous Rupture of Cerebral Aneurysm
Searching a dysfunction of corticotropic and thyrotropin axis during the acute phase ( ≤48h ) of a subarachnoid hemorrhage secondary to spontaneous rupture of cerebral aneurysm.
- Trial name
- HSA (NCT03655509)
- Testing
- Dynamic test ACTH stimulation
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Severe Sepsis or Septic Shock
Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?
Many biomarkers have been evaluated in sepsis, especially for prognostic purposes, but none has yet been shown to have sufficient sensitivity or specificity for routine use in clinical practice.
- Trial name
- HEP-SEPSIS (NCT03682003)
- Testing
- blood diagnostic tests
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Rennes University Hospital
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Hodgkin Disease Lymphoma
Sperm Epigenome in Hodgkin Lymphoma
Cancer treatments can have long-term effects on fertility. In men, scientific studies suggest that the process of sperm formation (spermatogenesis) may be disrupted even years after recovery, with potential consequences not only…
- Trial name
- SPELH (NCT07449832)
- Testing
- Additional semen samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Brain Diseases, Ischemic Stroke
Stroke Cerebral Reorganization Pathways (SPECTRE)
SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases.
- Conditions
- Brain Diseases, Ischemic Stroke, Stroke, Brain Infarction
- Trial name
- SPECTRE (NCT06784518)
- Testing
- Clinical scores and functional MRI
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
High Fidelity Simulation Training, Randomized Controlled Trials
Effect of Visual Deprivation of the Team Leader on Team Performance During Simulated Medical Emergencies
This multicenter randomized controlled study aims to evaluate the impact of temporary visual deprivation of the medical team leader on non-technical skills and team performance during high-fidelity simulated medical emergencies.
- Conditions
- High Fidelity Simulation Training, Randomized Controlled Trials, Education, Medical, Continuing, Education, Medical
- Trial name
- LEAD ME (NCT07427641)
- Testing
- Visual deprivation
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Drug Resistance
Mechanisms fo Clopidogrel Resistance in Older Adults (CEPAGE)
A clopidogrel resistance rate of 40-50% has been found in the population over 70 years of age, whereas biological resistance, associated with an increased risk of cardiovascular events, is observed in about 20-30% of younger…
- Trial name
- CEPAGE (NCT04990596)
- Testing
- additional blood sample
- Where
- 4 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years (STOP-I-SEP)
Further controlled and randomized prospective studies in Multiple sclerosis, analyzing the potential impact of treatment discontinuation on disability progression, focal disease activity and quality of life are needed.
- Trial name
- STOP-I-SEP (NCT03653273)
- Testing
- DMT withdrawal, DMT continuation
- Where
- 27 sites in France
- Volunteers
- 250 people
- Sponsor
- Rennes University Hospital
Spina Bifida
Anorectal Dysfunction in Patients Suffering From Spina Bifida : From Clinic to Neuro-epithelial Function (ANOSPIN)
The purpose of this study is to assess and explain (at least apart) anorectal disorders of patients with Spina Bifida by an automatic neuropathy responsive of enteric nervous system and epithelial barrier dysfunctions.
- Trial name
- ANOSPIN (NCT02440984)
- Testing
- Colonic biopsies during endoscopy
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Rennes University Hospital
Healthy
Anorectal Function and Neuronal-glial-epithelial Unit in Healthy Subjects
This study aims to assess the phenotype of the enteric nervous system (enteric neurons) in healthy subjects. The enteric nervous system (ENS) is composed by enteric neurons and enteric glial cells.
- Trial name
- ANOSAIN (NCT03054415)
- Testing
- endoscopy
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Apnea of Prematurity
Apnea Treatment in Premature Infants Using an Automatic Vibro-tactile Stimulator Triggered by the Detection of Apnea-bradycardia.
The goal of the SENSITACT system is to activate an adaptive kinesthetic stimulation to treat apnea-bradycardia events on preterm infants, while minimizing deleterious effects, in particular arousals that can be due either to…
- Trial name
- SENSITACT (NCT03651648)
- Testing
- SENSITACT System
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
Motor Asymmetry in Progressive Multiple Sclerosis Patients
Project Rational A better understanding of the causes of physical disability is an important unmet need in progressive Multiple Sclerosis patients.
- Trial name
- MAP-MS (NCT04918225)
- Testing
- Magnetic Resonance Imaging, Neurological examination, Multiple Sclerosis Functional Composite
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Stroke, Stroke Hemorrhagic
earlY Upper Limb Rehabilitation WIth EEG-Neurofeedback After Stroke
The aim of this study is to evaluate the effect of early rehabilitation treatment by electroencephalographic neurofeedback on upper limb motor function after stroke.
- Conditions
- Stroke, Stroke Hemorrhagic, Stroke, Ischemic, Stroke Rehabilitation
- Trial name
- YUWIN-Stroke (NCT05884762)
- Testing
- electroencephalographic neurofeedback
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
Epilepsy, Healthy Subjects
Mindfulness Meditation for Epilepsy
In one-third of epileptic patients treated in France, seizures persist despite drug treatment. These so-called "refractory" epilepsies are among the most severe.
- Trial name
- MIME (NCT04687904)
- Testing
- Mindfulness meditation training, Therapeutic education
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital