Clinical trials: sponsored by Rennes University Hospital
Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis
RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis.
The goal of this randomized clinical trial is to compare relapse remitting multiple sclerosis (RRMS) patients treated by ocrelizumab or by rituximab followed for 2 years.
- Trial name
- TRIO (NCT05758831)
- Testing
- Perfusion of treatment Rituximab, Perfusion of treatment Ocrelizumab
- Where
- 23 sites in France
- Volunteers
- 386 people
- Sponsor
- Rennes University Hospital
Emergency Department Patient
Impact on Mortality of Hospitalisation of a Patient in a Hospital Bed That Does Not Correspond to His Needs After a Visit to the Emergency Department
The aim of this study is to assess the impact of hospitalisation outside the referral requested by the emergency doctor on the mortality of patients admitted to emergency departments.
- Trial name
- RIGHT BED (NCT07347847)
- Testing
- No intervention
- Where
- 7 sites in France
- Volunteers
- 2,766 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Allogenic Adipose Tissue-derived Mesenchymal Stromal Cells for the Treatment of Primary Progressive Multiple Sclerosis
In this study, we propose, for the first time, to test the safety and the potential efficacy of repeated allogenic Adipose tissue-derived Mesenchymal Stromal Cells IT injections in Primary Progressive Multiple Sclerosis patients.
- Trial name
- MAESTRO-4MS (NCT06592703)
- Testing
- Adipose tissue-derived Mesenchymal Stromal Cells
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Transthyretin Amyloidosis, Amyloidosis, Hereditary
Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran
ATTRv amyloidosis is a systemic disease with two clinical forms, neurological and cardiological, which are sometimes combined (so-called mixed forms).
- Trial name
- MyocardON-TTR (NCT05873868)
- Testing
- Six minutes walk test, Kansas City questionnaire, COMPASS31 self questionnaire
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Relapsing-Remitting
Evaluation of the Impact of Lesions of the Motor and Proprioceptive Brain and Pan-medullary Pathways on Their Clinically and Electrophysiologically Assessed Function in Multiple Sclerosis
Multiple Sclerosis (MS) is the most common acquired neurological disease leading to disability, especially ambulatory, in young adults.
- Trial name
- MS-TRACTS (NCT04220814)
- Testing
- MRI, Electrophysiology
- Where
- 2 sites in France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Alzheimer Disease, Early Onset, Parkinson Disease
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
The aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal…
- Trial name
- NODAL (NCT06080659)
- Testing
- fMRI, CONFMEM
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Head Injury Trauma, Emergencies
Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?
At the emergencies rooms, patients with head trauma meeting one of the NICE criteria, which include antiplatelet inhibitors treatment, are considered as patients with a risk of cerebral haemorrage and are taken systematically for…
- Trial name
- TCAP (NCT03687528)
- Testing
- CT-scanner
- Where
- 12 sites in France
- Volunteers
- 3,200 people
- Sponsor
- Rennes University Hospital
Leukemia, Lymphoblastic, Acute, Pediatric
Childhood B-acute Lymphoblastic Leukaemia and Role of CD9 Gene Regulation in Relapse
B-acute lymphoblastic leukaemia (B-ALL) is the most common cancer in children, with 20% of patients relapsing. CD9, a transmembrane protein, is linked to the migratory and adhesion capacities of leukaemia cells and could be…
- Trial name
- REALL CD9 (NCT06649253)
- Testing
- Sampling bone tissue and blood
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Spina Bifida
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida.
- Trial name
- SPINLESS (NCT06041334)
- Testing
- Collection of a urine sample, Magnetic Resonance Imaging of the bladder
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Treatment Resistant Depression, Elderly Depression (≥65y.o.)
Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment
This trial aims at testing a new intensive, personalized functional targeting, transcranial magnetic stimulation technique for elderly patients (aged ≥ 65 years) suffering from a current treatment resistant depressive episode to…
- Trial name
- OLDEP-TBS (NCT07188753)
- Testing
- transcranial magnetic stimulation by accelerated & high-dose theta-burst, functional imaging guided, i
- Volunteers
- 186 people
- Sponsor
- Rennes University Hospital
Hysterectomies for Low- or Intermediate-risk Endometrial Carcinoma
Medico-economic Evaluation of Robot-assisted Laparoscopy Compared With Conventional Laparoscopy in Hysterectomy for Endometrial Cancer.
The standard treatment for endometrial cancer is surgery, as long as the stage of the disease and the patient's condition allow. It consists of hysterectomy (TSH) with bilateral adnexectomy.
- Trial name
- ROBOT-ECO-GYN (NCT06348719)
- Testing
- Robot-assisted laparoscopy, conventional laparoscopy, Prospective cohort study
- Where
- 15 sites in France
- Volunteers
- 1,680 people
- Sponsor
- Rennes University Hospital
Post Traumatic Stress Disorder
Efficacy of Traumatic Memory Modification Using Memory Reconsolidation and Propranolol Among Adolescents With PTSD
The aim of this study is to demonstrate the effectiveness of propranolol in blocking reconsolidation by reducing PTSD symptoms in the short and long term in adolescents with PTSD for more than 3 months.
- Trial name
- PROPRADO (NCT04921982)
- Testing
- Propranolol
- Where
- 10 sites in France
- Sponsor
- Rennes University Hospital
Organ Transplantation, Liver Dysfunction
Normothermic Oxygenated Perfusion (NMP) Viability Testing Before Transplantation of Discarded Livers
Liver transplantation (LT) is a highly effective treatment for end-stage liver disease and early-stage primary liver cancer. As such, the demand for donor livers greatly exceeds supply; in 2021 in France, 12.9% of patients on the…
- Conditions
- Organ Transplantation, Liver Dysfunction, Liver Diseases
- Trial name
- TRANSPERF (NCT06950398)
- Testing
- NMP viability testing
- Where
- 6 sites in France
- Volunteers
- 99 people
- Sponsor
- Rennes University Hospital
Lung Cancer
Resistance to the Tyrosine Kinase Inhibitor Osimertinib and Pharmacokinetics in Non-small Cell Lung Cancer
Osimertinib is a tyrosine kinase (TKI) inhibitor targeting EGF-R (epidermal growth factor receptor) and used in the management of patients with non-small cell lung cancer (NSCLC) with oncogenic drug addiction to EGF-R.
- Trial name
- RESISTYR (NCT05020275)
- Testing
- Blood Samples
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Obesity, Craving
Neurofeedback Based on Near-infrared Spectroscopy as a Therapy for Food Addiction in Obese Subjects.
The hypothesis is that the increase in dlPFC brain activity via near-infrared spectroscopy-based Neurofeedback (fNIRS-based NF) training based on near-infrared spectroscopy would allow an improvement of the eating behavior, thus…
- Trial name
- CaDOb (NCT05277714)
- Testing
- NF
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Colorectal Cancer Metastatic
Evaluation of Treatment PERSOnalization Based on Its Therapeutic Monitoring in Patients With Metastatic Colorectal Cancer Treated With REgorafenib
Regorafenib has demonstrated a significant benefit in overall survival in metastatic colorectal cancer (mCRC) patients. However, more than 50% of patients had severe adverse events (grade 3-4), leading to temporary or definitive…
- Trial name
- RePERSO (NCT04874207)
- Testing
- Regorafenib
- Where
- 9 sites in France
- Volunteers
- 110 people
- Sponsor
- Rennes University Hospital
Uterine Factor Infertility
Transplantation of Uterus for Uterine infertiLIty From Living Donor or Deceased Donor
Patients with absolute Uterine Factor Infertility (AUFI) are infertile due to the absence of a uterus. The absence of a uterus can be either iatrogenic (hysterectomy for gynecological pathology such as cancer or for obstetric…
- Trial name
- TULIPE (NCT05726305)
- Testing
- Live donor uterus transplantation, Deceased donor uterus transplantation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Post-surgery Critical Incare
LIDOCRIT : Effect of Continuous Intravenous LIDOcaine on Discomfort in Postoperative CRITical Care Inpatients
Although pain management in intensive care units and intensive care units has improved since the DOLOREA study, research into therapies and techniques to optimise analgesia is still needed.
- Trial name
- LIDOCRIT (NCT07043023)
- Testing
- Lidocaine (drug)
- Where
- 15 sites in France
- Volunteers
- 246 people
- Sponsor
- Rennes University Hospital
Ischemic Cardiomyopathy, Catheter Ablation of Ventricular Tachycardia
Endo-epicardial vs Endocardial-only Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy (EPIC-VT)
Radiofrequency ablation of ventricular tachycardias (VTs) is the gold standard treatment of refractory VTs in patients with ischaemic heart disease. In this setting, ablation is usually performed endocardially.
- Trial name
- EPIC-VT (NCT05888662)
- Testing
- Endo-epicardial ablation, endocardial ablation only
- Where
- 12 sites in France
- Volunteers
- 150 people
- Sponsor
- Rennes University Hospital
Bone Marrow Biopsy
QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study
The Osteo-Medullary Biopsy (BOM) is a procedure carried out by means of a trocar and makes it possible to obtain a bone core. This gesture is usually performed by performing a local subcutaneous anesthesia at the puncture point…
- Trial name
- QUALHYBOM (NCT05178849)
- Testing
- Hypnosis, Local anesthetic
- Where
- 4 sites in France
- Volunteers
- 180 people
- Sponsor
- Rennes University Hospital