Clinical trials: sponsored by Rush University Medical Center
Covid19, ME/CFS
Innovative Support for Patients With SARS-COV2 Infections (COVID-19) Registry (INSPIRE)
The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have…
- Conditions
- Covid19, ME/CFS, SARS COV2, Novel Coronavirus Infection
- Trial name
- INSPIRE (NCT04610515)
- Where
- 8 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- Rush University Medical Center
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Mental Health
Engagement With Digital Mental Health (DMH) Technologies in Pediatric Primary Care
The goal of this study is to use and adapt existing digital mental health technologies to advance the engagement, assessment, detection, treatment, and delivery of services for pediatric mental health in families from underserved…
- Trial name
- TeACH (NCT05466929)
- Testing
- TeACH System Resources
- Where
- 2 sites in United States
- Volunteers
- 365 people
- Sponsor
- Rush University Medical Center
Posttraumatic Stress Disorder, Chronic Pain
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Cognitive Processing Therapy (CPT) is an effective first-line, evidence-based treatment for posttraumatic stress disorder (PTSD).
- Trial name
- SGB (NCT05534126)
- Testing
- Stellate Ganglion Block Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
PTSD, Chronic Pain
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain.
- Trial name
- NCT05700279
- Testing
- Stellate Ganglion Block, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Rush University Medical Center
Lung Cancer
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak.
- Trial name
- NCT04954625
- Testing
- Autologous Blood Patch, Standard of Care (per Physician)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Covid19, ARDS
A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients
The proposed study will be conducted to investigate the mechanism of patients' responses to prone positioning with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) and non-COVID-19 ARDS utilizing…
- Trial name
- NCT04692779
- Testing
- Lung Ultrasound (LUS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Ventricular Tachycardia, Ischemic Cardiomyopathy
Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy
Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA).
- Trial name
- AIM-VT (NCT06138873)
- Testing
- Ablation-index guided ventricular tachycardia ablation, Ventricular tachycardia ablation with no AI-guidance
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Vasovagal Syncope, AV Block-2Nd Degree-Type 1
Cardioneuroablation for Recurrent Vasovagal Syncope and Bradyarrhythmias: The CNA-FWRD Registry
The CNA-FWRD Registry is an international prospective observational multicenter registry of patients with symptomatic vasovagal syncope and bradyarrhythmias managed under routine care by medical therapy and radiofrequency…
- Conditions
- Vasovagal Syncope, AV Block-2Nd Degree-Type 1, Sinus Pause
- Trial name
- CNA-FWRD (NCT06166277)
- Testing
- Ablation procedure
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Hypertension
Novartis - Closing the Gap in Cardiovascular Risk: Engage, Empower, Evaluate
This study aims to decrease the racial gap in high blood pressure in African American and Latinx patients in Rush University Medical Center clinics.
- Trial name
- E3 (NCT06027905)
- Testing
- E3 Remote Monitoring and Social Intervention
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- Rush University Medical Center
Cirrhosis, Liver, Volume Overload
Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients
A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients…
- Conditions
- Cirrhosis, Liver, Volume Overload, Fluid Overload
- Trial name
- NCT04216784
- Testing
- Furosemide Injection, Albumin Human
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Rush University Medical Center
Clinical Trials
Clinical Trial Preference Study
Population subgroups experiencing health disparities are often also underrepresented in clinical trials. These groups include individuals from minoritized racial and ethnic groups, people from lower socioeconomic backgrounds, and…
- Trial name
- NCT06735469
- Testing
- Discrete choice experiment
- Where
- United States
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Family Planning, Contraception
Linking Inter-professional Newborn and Contraception Care
Pregnancies conceived within 18 months of a prior delivery (termed short inter-pregnancy interval [IPI]) place mothers and infants at high risk for poor health outcomes and affect nearly one third of women in the U.S.
- Conditions
- Family Planning, Contraception, PostPartum
- Trial name
- LINCC (NCT04092530)
- Testing
- LINCC intervention - enable co-schedule feature
- Where
- 5 sites in United States
- Volunteers
- 2,518 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Infection, Drainage
Comparison of Negative Pressure Wound Therapy vs. Conventional Dressings for Prevention of Wound Complications After Revision THA
Wound complications and surgical site infections following revision total joint arthroplasty result in significant morbidity and cost.
- Trial name
- NCT03321799
- Testing
- Negative Pressure Wound Therapy (NPWT), Sterile Antimicrobial Dressings
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Physical Activity
Testing Adaptive Interventions to Improve Physical Activity for Sedentary Women
This study employs a Sequential Multiple Assignment Randomized Trial (SMART) and aims to determine the most effective adaptive intervention combining four efficacious treatments (enhanced physical activity monitor, motivational…
- Trial name
- NCT03558828
- Testing
- Step 1: PA Monitor, Step 1: PA Monitor + Text, Step 2: PA Monitor with Calls
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Full Thickness Rotator Cuff Tear
Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair
The primary objective of this study is to compare the clinical outcomes of arthroscopic rotator cuff repair with and without augmentation of mesenchymal stem cells (MSCs).
- Trial name
- NCT02484950
- Testing
- Mesenchymal stem cell augmentation in rotator cuff repair, Standard arthroscopic rotator cuff repair
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rush University Medical Center
Dislocation, Hip
Dual Mobility in "High Risk" Patients
The aim of this study is to compare clinical outcomes of patients considered to be high risk for prosthetic dislocation undergoing primary total hip arthroplasty (THA) with the use of a dual mobility bearing versus a…
- Trial name
- NCT04092634
- Testing
- Dual mobility implant, Traditional, Single-bearing hip implant
- Where
- 4 sites in United States
- Volunteers
- 412 people
- Sponsor
- Rush University Medical Center
Stage III Non-small-cell Lung Cancer
Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLC
Elderly (age 70 years or older) or >18 years old AND poor risk (ECOG 2) newly diagnosed stage IIIA-C (AJCC 8th edition) inoperable non-small cell lung cancer (NSCLC) patients are eligible to participate in this phase II open…
- Trial name
- ESR1814205 (NCT04441138)
- Testing
- Durvalumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center