Clinical trials: sponsored by Sahlgrenska University Hospital
Diabete Mellitus
Prediction Model for the Risk of Developing Foot Ulcers in Diabetes
Introduction Foot ulcers in diabetes mellitus (DM) are a common and serious complication that can lead to infection, amputation, and increased mortality.
- Trial name
- NCT07307183
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Sahlgrenska University Hospital
Kidney Failure, Chronic, Peritoneal Dialysis-associated Peritonitis
Prevention of Peritonitis in Peritoneal Dialysis
BACKGROUND: Peritonitis remains a significant problem in peritoneal dialysis (PD). It is the leading cause of technique failure, and contributes to mortality. The incidence is highest during the first year of treatment.
- Conditions
- Kidney Failure, Chronic, Peritoneal Dialysis-associated Peritonitis, Dialysis Capd Infection
- Trial name
- PEPS (NCT01293799)
- Testing
- Retraining
- Where
- Sweden
- Volunteers
- 713 people
- Sponsor
- Sahlgrenska University Hospital
Ulcerative Colitis (Disorder), Familial Adenomatous Polyposis (FAP)
LATA-IBD TRIAL a Controlled Feasibility Study for the Introduction of Transanal Minimally Invasive IPAA-Surgery. Evaluation of Operative Results and Bowel Function After Introducing Transanal IPAA-surgery to Replace Conventional Laparoscopic IPAA-surgery.
This study compares the operative and functional outcomes of adding a transanal pathway to laparoscopic pelvic pouch surgery. The transanal pathway enables the surgeon to have better control when dividing the rectum and it may…
- Trial name
- LATA-IBD (NCT07278687)
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Sahlgrenska University Hospital
Mesenteric Artery Ischemia
Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.
The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023.
- Trial name
- AMIGO (NCT07274306)
- Where
- 2 sites in Sweden
- Volunteers
- 2,446 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Postoperative Pain
Placebo Effect In Spinal Cord Electrical Stimulation for Pain
Objective: To evaluate if spinal cord stimulation (SCS) performs better than placebo (no stimulation) in the long term to reduce persistent neuropathic leg pain refractory to medication and other conservative treatments in…
- Trial name
- PISCES (NCT06585033)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in Netherlands, Norway and 1 more
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Prolapse, Fecal Incontinence
Recurrence and Bowel Function After Laparoscopic Vaginorectopexy, a Modified Anterior Rectopexy
Several pelvic prolapses can render defecation difficulties and they are often treated with different surgical techniques. This study will evaluate a novel variation of a laparoscopic technique used to treat rectal prolapse that…
- Conditions
- Rectal Prolapse, Fecal Incontinence, Defecation Disorder, Enterocele
- Trial name
- NCT06330857
- Testing
- Laparoscopic vaginorectopexy
- Volunteers
- 25 people
- Sponsor
- Sahlgrenska University Hospital
Irritable Bowel Syndrome With Diarrhea
The Effects of Carbohydrates in Irritable Bowel Syndrome
Food and their components are often reported as gastrointestinal (GI) symptom triggers in patients with IBS. The current interest in dietary management in IBS, has largely focused on the negative effect of poorly absorbed and…
- Trial name
- FIBS (NCT04830410)
- Testing
- Fructan reintroduction
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Sahlgrenska University Hospital
Colonic Polyp, Colon Lesion
Comparative Analysis of AI Software for Enhanced Polyp Detection and Diagnosis
Purpose \& Research Questions The purpose of this study is to evaluate whether artificial intelligence (AI) improves the detection of polyps and whether the system can classify the type and severity of detected changes.
- Trial name
- NCT06077435
- Testing
- AI
- Where
- Sweden
- Volunteers
- 915 people
- Sponsor
- Sahlgrenska University Hospital
Liver Ablation, High Frequency Jet Ventilation
Comparison of Transcutaneous and Arterial Carbon Dioxide Sampling During Jet Ventilation, a Prospective. Study on Patients Undergoing Percutaneous Liver Tumour Radiofrequency Ablation
The study aims to compare the readings from two methods of monitoring carbon dioxide levels during jet ventilation when normal end-tidal monitoring is not possible.
- Trial name
- NCT07211763
- Testing
- No Interventions
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Hepatic Disorders, Intestinal Failure-associated Liver Disease
VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease.
- Conditions
- Hepatic Disorders, Intestinal Failure-associated Liver Disease, Cystic Fibrosis Liver Disease, MAFLD
- Trial name
- VALiBi-PED (NCT07202910)
- Where
- Sweden
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
COPD, Obesity &Amp; Overweight
The Impact of a Weight Reduction Intervention on Clinical Outcomes in Patients With Obesity and COPD
Obesity and COPD are increasingly common and often coexist, worsening health outcomes such as reduced lung function, exercise capacity, and increased systemic inflammation.
- Trial name
- NCT07159594
- Testing
- Energy restriction
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Neoplasm Malignant
Latitude - Lateral Lymph Node Attitude Study
Patients with advanced rectal cancer can sometimes have suspected tumour affected lymph nodes outside the standard operating field. These patients often receive preoperative treatment before surgery.
- Trial name
- Latitude (NCT06896578)
- Testing
- Lateral lymph node dissection
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Sahlgrenska University Hospital
Peripheral Arterial Disease, Critical Limb Ischemia
Swedish Drug-elution Trial in Peripheral Arterial Disease
Peripheral arterial disease (PAD) causes reduced blood flow to the lower limb(s) due to stenosis or occlusion in the supplying arteries.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- SWEDEPAD (NCT02051088)
- Testing
- Revascularization with drug-eluting technology, Revascularization without drug-eluting technology, drug-coated balloons and/or drug-eluting stents
- Where
- Sweden
- Volunteers
- 3,556 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer Patients, Rectal Cancer Surgery
Walking and Sitting Difficulties After Rectal Cancer Surgery
Earlier studies have shown that many patients (up to 30%) who have had a major surgery for rectal cancer, called a rectum amputation (where the entire rectum and anus are removed and the person gets a permanent stoma), still have…
- Conditions
- Rectal Cancer Patients, Rectal Cancer Surgery, Rectal Cancer, Radiotherapy, Rectal Cancer
- Trial name
- WASA (NCT07035600)
- Testing
- Targeted leaderled training program, Control arm with WHO recommendation on physical activity
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Neoplasms
Local Recurrence Due to Rectal Cancer in Sweden
The aim of this retrospective national registry study is to validate the reporting of local recurrence in the registry. Another aim is to identify preoperative risk factors for local recurrence.
- Trial name
- LERIS (NCT04404777)
- Testing
- Treatment for local recurrence with surgery or other treatments
- Where
- Sweden
- Volunteers
- 12,000 people
- Sponsor
- Sahlgrenska University Hospital
Cardiac Allograft Vasculopathy
Comparing PCCT With ICA and IVUS in Detecting Cardiac Allograft Vasculopathy
In traditional coronary artery disease, patients often experience symptoms such as angina. However, heart transplant patients lack nerve connections in the transplanted heart and therefore usually do not notice any symptoms.
- Trial name
- CAVIAR (NCT07020039)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Epilepsy
Prospective Regional Epilepsy Database
PREDICT is an observational study following adults with an unprovoked seizure or epilepsy in the health care region of western Sweden.
- Trial name
- PREDICT (NCT04559919)
- Testing
- Seizure status, Tests, Epilepsy
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Sahlgrenska University Hospital
COVID-19 Pandemic, Intensive Care Unit Syndrome
Post-ICU Follow-up Study in Covid-19 Patients
A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
- Conditions
- COVID-19 Pandemic, Intensive Care Unit Syndrome, Delirium
- Trial name
- NCT05299346
- Testing
- Follow up
- Where
- Sweden
- Volunteers
- 793 people
- Sponsor
- Sahlgrenska University Hospital
Benign Prostatic Hyperplasia
Patient-reported Pain and Symptom Relief During Three Months After Surgery for Benign Prostatic Hyperplasia
This is a prospective observational study in patients undergoing surgery for benign prostatic hyperplasia (BPH). The purpose of the study is to investigate in great detail patients' recovery after surgery for BPH regarding pain…
- Trial name
- NCT06852859
- Testing
- Transurethral resection of the prostate, Transurethral vaporization of the prostate, GreenLight laser enucleation of the prostate
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Sahlgrenska University Hospital