Clinical trials: sponsored by Semmelweis University
Coronary Artery Disease, Coronary Computed Tomography Angiography
Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA
This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography…
- Conditions
- Coronary Artery Disease, Coronary Computed Tomography Angiography, SPECT, Heart Diseases
- Trial name
- MY-FUSION (NCT06670768)
- Testing
- Stress Dynamic MPI SPECT, Stress Static MPI SPECT, Rest Dynamic MPI SPECT
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Localized Gingival Enlargement, Epulides
Periodontal Plastic Reconstruction of Soft Tissue Dehiscences After the Removal of Localized Gingival Enlargements
Non-inflammatory recessions and Miller class I-II-III. mucogingival defects after elimination of localized gingival enlargements are frequently encountered challenges in the daily practice. In Miller class II-III.
- Conditions
- Localized Gingival Enlargement, Epulides, Recurrence, Periodontal; Lesion
- Trial name
- NCT06210789
- Testing
- Surgical excision
- Where
- Hungary
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Gingival Recession, Generalized
NovoMatrix in Gingival Recession Coverage: Case Series
Twenty patients seeking treatment for gingival recession coverage, ranging from 20-70 years of age with multiple Miller Class I or II buccal gingival recessions (depth≥3 mm, at least 3 adjacent teeth) will be recruited for this…
- Trial name
- NCT06409468
- Testing
- Subperiostal tunnel in conjunction with Novomatrix
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Anemia, Coagulopathy
Patient Blood Management Implementation in CEE Study
The goal of the study is data collection on available fixed and personal assets required for Patient Blood Management (elements of the 3 pillars of PBM) in Central Eastern Europe countries hospitals, status before and after PBM…
- Trial name
- CEEPBM (NCT06878105)
- Testing
- Data collection on interventions performs as per medical routine
- Where
- Hungary
- Volunteers
- 2,000 people
- Sponsor
- Semmelweis University
Breastfeeding Education, Lactating Mother
Breastfeeding Advices on OTC Medicines With the Internet: What is the Best Medium
Pharmacotherapy for lactating women in Hungary presents a unique challenge. While certain medications may pose risks to the infant or reduce breast milk production, the unnecessary avoidance of treatment can also be harmful.
- Conditions
- Breastfeeding Education, Lactating Mother, Breastfeeding Mothers, Lactation
- Trial name
- LACT-ED (NCT06863597)
- Testing
- Video content, Written content, Podcast content
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Dental Caries Extending to Pulp, Pulp Disease, Dental
The Effect of Different Risk Factors on the Success Rate of VPT
This study aims to evaluate the effectiveness of various vital pulp therapy (VPT) methods, such as direct pulp capping, partial pulpotomy, and total pulpotomy, in maintaining pulp vitality following pulp exposure.
- Conditions
- Dental Caries Extending to Pulp, Pulp Disease, Dental, Irreversible Pulpitis, Reversible Pulpitis
- Trial name
- NCT06844448
- Testing
- with Biodentine, with MTA
- Where
- Hungary
- Volunteers
- 400 people
- Sponsor
- Semmelweis University
Cerebral Palsy
Pilot Study on Breathing Exercises and Pulmonary Function in Children With Cerebral Palsy: A Randomized Trial
This pilot study is a randomized controlled trial aimed at investigating the efficacy of protocolized conductive breathing exercises combined with regular air ventilation, in addition to standard care, on various aspects of…
- Trial name
- NCT06840626
- Testing
- Series of breathing exercises
- Where
- Hungary
- Volunteers
- 55 people
- Sponsor
- Semmelweis University
Gingivitis and Periodontal Diseases
Investigating the Periodontal Status of Traditional and Heated Tobacco Product Users
This cross-sectional observational study aims to compare the clinical and radiographic periodontal status, as well as gingival crevicular fluid volume, among cigarette smokers, heated-tobacco product users, and non-smokers.
- Trial name
- INPER-THT (NCT06784817)
- Where
- Hungary
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hypoxic-Ischaemic Encephalopathy, Neonatal Encephalopathy
Intranasal Breast Milk Therapy in HIE
This is an open-label prospective single-center randomized controlled trial to evaluate the effect of intranasal breast milk in hypoxic-ischemic encephalopathic neonates receiving therapeutic hypothermia on long term…
- Conditions
- Hypoxic-Ischaemic Encephalopathy, Neonatal Encephalopathy, Perinatal Asphyxia, Neonatal Hypoxic Ischemic Encephalopathy
- Trial name
- NEO-BRIGHT (NCT06746532)
- Testing
- Intranasal breast milk
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Semmelweis University
Periapical Diseases, Radicular Cyst
PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study
The goal of this clinical trial is to determine whether a PRF (platelet-rich fibrin) membrane helps improve recovery after periapical surgery in adults.
- Conditions
- Periapical Diseases, Radicular Cyst, Granuloma, Postoperative Complications
- Trial name
- NCT06739200
- Testing
- Platelet-Rich Fibrin (PRF) Membrane
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Impact of Catheter Stability on the Outcomes With Very High Power Short Duration Ablation
Background: Atrial fibrillation (AF), the most common cardiac rhythm disorder can be treated with pulmonary vein isolation (PVI). One technique for PVI is point-by-point radiofrequency ablation.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Pulmonary Vein Isolation
- Trial name
- SVtag (NCT06721221)
- Testing
- Point-by-point PVI with the QDot Micro catheter in QMODE+ setting with the Svtag software
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University
Pulmonary Embolism Subacute Massive, Complication of Treatment
Safe Delivery of Thrombolytic Treatment for Pulmonary Embolism Using ClotPro® Viscoelastic Tests
The aim of this work was to reduce the bleeding risk during thrombolysis using the viscoelastic blood coagulation tests.
- Conditions
- Pulmonary Embolism Subacute Massive, Complication of Treatment, Fibrinolysis; Hemorrhage
- Trial name
- NCT06667882
- Testing
- Alteplase Injectable Product
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Semmelweis University
Atrial Fibrillation (AF), Esophageal Perforation
Esophageal Safety of High and Very High Power Short Duration Pulmonary Vein Isolation: a Randomized Comparison of the 50W and 90W Power Settings
Pulmonary vein isolation (PVI) is the most effective means of maintaining sinus rhythm in atrial fibrillation (AF), while a widely used approach to PVI is point-by-point radiofrequency (RF) catheter ablation.
- Conditions
- Atrial Fibrillation (AF), Esophageal Perforation, Esophageal Perforation, Traumatic
- Trial name
- HPSD-Esophagus (NCT06617442)
- Testing
- Pulmonary vein isolation
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Semmelweis University
Hallucinations, Auditory, Schizophrenia Spectrum and Other Psychotic Disorders
VR-based Avatar Therapy for Treatment of Auditory Hallucinations
The primary aim of this study is to evaluate the safety and efficacy of AVATAR therapy, developed to address residual auditory hallucinations persisting despite medication in schizophrenia spectrum disorder.
- Trial name
- NCT06505564
- Testing
- AVATAR therapy
- Where
- 4 sites in Hungary, Poland and 1 more
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic
PhotobiomoduLation for pAtientS With Advanced hEart failuRe
The objective of the study is to examine the effectiveness of photobiomodulation therapy in patients with advanced-stage heart failure with reduced ejection fraction (HFrEF), who have been referred but ineligible for a heart…
- Trial name
- LASER (NCT06501313)
- Testing
- Photobiomodulation
- Volunteers
- 70 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Polycystic Ovary Syndrome, Vitamin D Deficiency
30000 IU Per Week Vitamin D Treatment in PCOS Patients
This is a human, II/b phase, multicentre, randomised, double blind, placebo-controlled study to assess the safety and the efficacy of a weekly administered dose of 30,000 IU vitamin D (colecalciferol) in deficient patients…
- Trial name
- NCT04840238
- Testing
- Cholecalciferol
- Where
- 8 sites in Hungary
- Volunteers
- 115 people
- Sponsor
- Semmelweis University
Vitamin D Deficiency
Controlled, Randomized, Four-arm Comparative, Open Label, Multi-centric Clinical Trial to Compare the Efficacy and Safety Parameters of the Once-a-week or Once-a-month Administered 7000 IU, or 30000 IU Vitamin D (Cholecalciferol) to a 1000 IU Dosage Applied Daily in Vitamin D Deficient Patients
Circa-annual variations in 25-hydroxyvitamin D [25(OH)D] levels have been well established, and there also seems to be an effect of season on bone turnover and bone mass.
- Trial name
- NCT02069990
- Testing
- Cholecalciferol
- Where
- 2 sites in Hungary
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Vasodilation, Oral Soft Tissue Conditions
Investigation of Endothelium-dependent Vasodilation in Human Gingiva
The first aim of this study is to create a cumulative dose-response curve for acetylcholine in men (low serum estrogen levels) to determine the lowest concentration with which we can induce a maximal vasodilation effect on the…
- Trial name
- NCT06454084
- Testing
- Acetylcholine Chloride
- Where
- Hungary
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Dental Implants, Single-Tooth, Dental Impression Technique
Digital vs Conventional Impression in Capturing the Emergence Profile Around Maxillary Anterior Implant-supported Crowns
This study compares conventional impression and cast fabrication to direct/indirect digital scannig and 3D printed casts regarding their accuracy in replicating the peri-implant emergence profile of single implants in the…
- Trial name
- NCT06425770
- Testing
- indirect digital impression and 3D printed cast, direct digital impression, conventional impresion and cast
- Where
- Hungary
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Dental Implants, Single-Tooth, Dental Implant-Abutment Design
Effect of Abutment Configuration on Peri-implant Soft and Hard Tissue in the Esthetic Zone - Randomized Clinical Trial
The aims of our study are to investigate in patients with immediate implantation replacing a single tooth in the maxillary anterior (#FDI 15-25) region the effect of (a) custom vs cylindrical stock healing abutments, then (b)…
- Trial name
- NCT06407271
- Testing
- CAD/CAM custom ZrO2 healing abutment, Cylindrical ZrO2 healing abutment
- Where
- Hungary
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Semmelweis University