Clinical trials: sponsored by Shanghai Chest Hospital
Atrial Fibrillation, Catheter Ablation
Electroacupuncture Intervention in Catheter Ablation of Atrial Fibrillation
This is a randomized control trial to determine whether electroacupuncture(EA) intervention with Morphine can reduce the intraoperative pain and early post-operative complications in patients undergoing catheter ablation of…
- Trial name
- NCT05575544
- Testing
- Acupuncture plus morphine
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Left Atrial Isolation by Catheter Ablation in Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is a single-arm clinical trial evaluating the efficacy and safety of left atrial isolation achieved by catheter ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05173779
- Testing
- Left atrial isolation by catheter ablation
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
China Lung Cancer Screening (CLUS) Study Version 3.0
CLUS version 1.0, had proven that LDCT led to a 74.1% increase in detecting early-stage lung cancer compare to usual care (NCT02898441).
- Trial name
- NCT05494021
- Testing
- Whole-process management software, LDCT detection
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Nodules
ENB for the Diagnosis of PPNs:a Real World Study
The study is designed as a multi-center prospective trial of ENB for the diagnosis of peripheral pulmonary nodules in the real world. The purpose of the study is to identify the optimal method of using ENB.
- Trial name
- NCT03716284
- Testing
- Electromagnetic navigation bronchoscopy (ENB)
- Where
- China
- Volunteers
- 479 people
- Sponsor
- Shanghai Chest Hospital
Non Small Cell Lung Cancer
Neoadjuvant Therapy in Resectable Non-Small Cell Lung Cancer Stages IIB-IIIB
This study aims to investigate the efficacy and safety of targeted therapy and chemotherapy±immunotherapy as neoadjuvant therapy in stage IIB-IIIB NSCLC patients.（observational study）
- Trial name
- NCT04197076
- Testing
- anti-PD-1 or anti-PD-L1, EGFR-TKI, ALK inhibitor, ROS1 inhibitor, investigator decided
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Comparison of Peri-procedural Complications of Intracardiac Echocardiography and Transesophageal Echocardiography in Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia. Worldwide, the incidence of atrial fibrillation in men and women is 596.2 per 100,000 and 373.1 per 100,000, respectively.
- Trial name
- NCT05466266
- Testing
- ICE, TEE
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer, Minimal Residual Disease
Sintilimab Combined With Anlotinib for Perioperative Non-small Cell Lung Cancer Based on MRD Evaluation
To study the efficacy of sintilimab combined with anlotinib for perioperative non-small cell lung cancer. To explore the clearance effect of sintilimab combined with anlotinib for postoperative adjuvant therapy based on…
- Conditions
- Non-small Cell Lung Cancer, Minimal Residual Disease, Immunotherapy, Anti-angiogenesis
- Trial name
- NCT05460195
- Testing
- sintilimab combined with anlotinib, sintilimab monotherapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
CARTO-Finder Guided Ablation Versus Multiscale Entropy Guided Ablation in Persistent Atrial Fibrillation
This is a randomized control trial to compare the efficacy and safety of CARTO-Finder-guided ablation plus pulmonary vein isolation versus multiscale entropy (MSE)-guided pulmonary vein isolation in patients with persistent…
- Trial name
- NCT05454111
- Testing
- Multiscale entropy-guided ablation plus PVI, CARTO-Finder-guided ablation plus PVI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
NSCLC Stage IV, Checkpoint Inhibitor
Nivolumab Combined With Anlotinib as Re-challenge Treatment in Advanced NSCLC
This is a phase Ib/IIa, open-label, single center study, aiming to investigate safety and efficacy of nivolumab (administered intravenously) in combination with anlotinib (administered orally) in immunotherapy-treated advanced…
- Trial name
- NCT04507906
- Testing
- Nivolumab Combined with Anlotinib
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai Chest Hospital
Lung Neoplasms
China Lung Cancer Screening (CLUS) Study Version 2.0
Our previous study, china lung cancer screening study version 1.0, had proven that LDCT led to a 74.1% increase in detecting early-stage lung cancer compare to usual care (NCT02898441).
- Trial name
- NCT03975504
- Testing
- Low Dose Computed Tomography, artificial intelligence (AI), autofluorescence imaging (AFI)
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation, Right Atrial Enlargement
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement
This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.
- Trial name
- NCT05227586
- Testing
- Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation, Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer
Exosomes Detection for the Prediction of the Efficacy and Adverse Reactions of Anlotinib in Patients With Advanced NSCLC
Exosomes detection for the prediction of the efficacy and adverse reactions of Anlotinib in patients with advanced NSCLC
- Trial name
- NCT05218759
- Testing
- Anlotinib
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
NSCLC, Stage III
SHR-1701 for Consolidation Therapy After Concurrent Chemoradiotherapy in Inoperable Stage III NSCLC
This is a phase II, open-label, single arm study, aiming to investigate the safety and efficacy of SHR-1701 consolidation therapy after concurrent chemoradiotherapy in inoperable stage III non-small-cell lung cancer (NSCLC)
- Trial name
- NCT05177497
- Testing
- SHR-1701
- Volunteers
- 19 people
- Sponsor
- Shanghai Chest Hospital
SPN, Lung Cancer
Augmented Reality-assisted Localization of Solitary Pulmonary Nodules for Precise Sublobar Lung Resection
With the popularization of CT screening, the detection rate of small lung nodules has greatly increased. Therefore, the clinical thoracoscopic lung nodule biopsy and sub-lobectomy for radical resection of lung cancer are greatly…
- Trial name
- ARPL (NCT05162235)
- Testing
- Augmented Reality-assisted localization of solitary pulmonary nodule
- Volunteers
- 20 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Catheter Ablation and Surgical Ablation of Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is an open label, randomized parallel control clinical trial evaluating the efficacy and safety of catheter ablation and surgical ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05153486
- Testing
- Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + driver ablation, Circumferential pulmonary vein isolation + linear ablation + vein of Marshall ethanol infusion, Surgical ablation
- Volunteers
- 300 people
- Sponsor
- Shanghai Chest Hospital
Non Small Cell Lung Cancer
Tislelizumab Combined With Chemotherapy With or Without Bevacizumab in TKI-Resistant EGFR-Mutated Non-squamous NSCLC
A phase II, open-label, multicenter, two cohorts, prospective clinical study to investigate the efficacy and safety of tislelizumab (anti-pd1 antibody) combined with chemotherapy with or without bevacizumab in non-squamous…
- Trial name
- NCT04405674
- Testing
- Tislelizumab, Carboplatin, Pemetrexed
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation
This is a multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial, to evaluate the effect of catgut embedding in acupoints of Neiguan and Zusanli in reducing early recurrence and improving…
- Trial name
- NCT05125042
- Testing
- Amiodarone hydrochloride tablet + acupoint catgut embedding, Amiodarone hydrochloride tablet
- Volunteers
- 120 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinomas
Salvage Immunotherapy and Chemotherapy in Esophageal Squamous Cell Carcinoma Patients Nonresponding to Initial Neoadjuvant Chemoradiotherapy
This is an investigator-initiated, single-arm, exploratory clinical study.The study population consisted of esophageal squamous cell carcinoma patients nonresponding to initial neoadjuvant chemoradiotherapy.
- Trial name
- SINCERE (NCT05103501)
- Testing
- PF regimen (cis-platinum ; 5-fluorouracil ) combined with PD-1 inhibitors（pembrolizumab）
- Volunteers
- 54 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Driver Ablation of Persistent Atrial Fibrillation With Severe Atrial Fibrosis.
This is an open label, randomized parallel control clinical trial, to demonstrate the role of driver mechanism in maintenance substrate of persistent atrial fibrillation with severe atrial fibrosis, and evaluate the clinical…
- Trial name
- NCT05085912
- Testing
- Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + driver ablation, Circumferential pulmonary vein isolation + linear ablation + posterior wall box isolation, Circumferential pulmonary vein isolation + linear ablation + vein of Marshall ethanol infusion
- Volunteers
- 300 people
- Sponsor
- Shanghai Chest Hospital
Sinus Bradycardia
Cardiac Autonomic Nerve Improvement and Pacemaker Therapy in Patients With Sinus Bradycardia
This is a multicenter randomized controlled study. By comparing patients with sinus bradycardia undergoing cardiac autonomic ganglion ablation and pacemaker therapy, and long-term follow-up to evaluate its safety and…
- Trial name
- NCT05021627
- Testing
- Cardiac autonomic nerve modification, Pacemaker implantation
- Volunteers
- 240 people
- Sponsor
- Shanghai Chest Hospital