Clinical trials: sponsored by Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma, Apatinib
Apatinib in the Treatment of Recurrence or Metastasis of Esophageal Cancer
It was difficult to obtain clinical benefits through traditional chemotherapy and radiotherapy for the patients who have recurrence or metastasis tumor even though they have received first-line chemotherapy or combined…
- Conditions
- Esophageal Squamous Cell Carcinoma, Apatinib, Recurrence, Metastasis
- Trial name
- NCT03913182
- Testing
- apatinib
- Where
- China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
ENB Guided MWA for Early-stage Peripheral Lung Cancer
The objective of the study was to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy (ENB) guided microwave ablation (MWA) for the treatment of early-stage peripheral lung cancer.
- Trial name
- NCT04005157
- Testing
- MWA, ENB
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Analysis of Re-biopsy Specimens in Advanced NSCLC With Acquired Resistance of EGFR-TKI Targeted Therapy
The objective of the study is to reveal the acquired resistance mechanism of the first and second generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) in tissue and plasma using Next Generation…
- Trial name
- NCT03309462
- Testing
- Miseq sequencer
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Neoplasms
NGS-based Large-panel in Targeted Drug Delivery and Immunotherapy of Lung Cancer
Companion diagnosis by large-panel is in increasing acceptance and need during clinical cancer management. The purpose of this trial is to investigate the benefit of large-panel NGS analysis in companion diagnosis of advanced…
- Trial name
- NCT04159337
- Testing
- The method of gene mutation detection
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Chest Hospital
Lung Squamous Cell Carcinoma
To Evaluate the Efficacy of Afatinib in Advanced Lung Squamous Cell Carcinoma With EGFR Sensitive Mutation
This is an open-label, sing-arm, single site, phase IV clinical study. The main objective is to evaluate the efficacy of afatinib in LSQC patients with EGFR sensitive mutation, and to explore the clinical factors which might be…
- Trial name
- NCT04132102
- Testing
- Afatinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer
Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage Esophageal Squamous Cell Carcinoma
The ad-ESD trial is phase III randomized trial to compare adjuvant esophagectomy and chemoradiation for patients with clinical stage N0 and pathological stage T1b squamous cell carcinoma (after endoscopic submucosal dissection).
- Trial name
- NCT04135664
- Testing
- esophagectomy, chemoradiation, active surveillance
- Where
- 6 sites in China
- Volunteers
- 176 people
- Sponsor
- Shanghai Chest Hospital
Lung Adenocarcinoma, EGFR Activating Mutation
EGFR-TKI Combined With Concurrent or Sequential Chemotherapy for Patients of Gradual Progression
To compare the efficacy of simultaneous EGFR-TKI and chemotherapy with that of sequential treatment after patients gradually progressed from first-line EGFR-TKI treatment.
- Trial name
- NCT03544814
- Testing
- icotinib combined with pemetrexed plus cisplatin, first icotinib and then pemetrexed plus cisplatin
- Volunteers
- 99 people
- Sponsor
- Shanghai Chest Hospital
Carcinoma, Non-small Cell Lung Cancer
Combination Therapy of Sintilimab and Anlotinib as a First-line Treatment in Advanced NSCLC (SUNRISE)
This is an open label, multi-center, randomized control phase II trial, to compare the efficacy and safety of sintilimab combined with anlotinib versus standard platinum-based chemotherapy as a first-line treatment in advanced…
- Trial name
- NCT04124731
- Testing
- sintilimab plus anlotinib, Chemotherapy
- Volunteers
- 98 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma
KN046 in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
This is an open-label, phase II study of KN046 combined with chemotherapy and palliative radiotherapy in patients with recurrent or metastatic esophageal squamous cell carcinoma to evaluate the safety, efficacy and tolerance.
- Trial name
- NCT03927495
- Testing
- KN046, palliative radiotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Lung Nodule
Non-Invasive ctDNA Methylation Detection for Lung Nodule Patients
Low-dose computed tomography (LDCT) is recommended for early-stage lung cancer screening. However, it is often difficult to determine indolent lesions from more aggressive tumors without an invasive intervention or prolonged…
- Trial name
- NCT03685669
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Electromagnetic Navigation Versus CT Guided TTNA in the Diagnosis of Early Peripheral Lung Cancer
The purpose of this study is to compare Electromagnetic navigation guided with CT-guided transthoracic needle aspiration (TTNA) in the diagnosis of pulmonary peripheral nodule.
- Trial name
- NCT03802266
- Testing
- Electromagnetic Navigation guided transthoracic needle aspiration, CT-guided Transthoracic Needle Aspiration
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
UTB-VBN-EBUS With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the feasibility,efficacy and safety of ultrathin bronchoscopy(UTB) combined with virtual bronchoscopic navigation(VBN) and endobronchial ultrasound(EBUS) for the diagnosis of peripheral…
- Trial name
- NCT02664259
- Testing
- VBN, EBUS, X-ray
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Advanced Stage
First-line Combination Treatment Based on Anlotinib
The aim of this study is to explore safety and therapeutic efficacy of anlotinib combined with erlotinib/chemotherapy/IBI308 as first-line treatment in advanced NSCLC patients.
- Trial name
- NCT03628521
- Testing
- Anlotinib，Erlotinib，IBI308，Pemetrexed，gemcitabine，carboplatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Chest Hospital
Ultrasonography
Intraoperative Ultrasonographic Localization of Pulmonary Nodules in VATS
This study is conducted to explore the feasibility and value of Intraoperative ultrasonographic localization of pulmonary nodules in video-assisted thoracoscopic surgery (VATS).
- Trial name
- NCT03599505
- Testing
- localization group
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Nodules
ENB in the Diagnosis of Peripheral Pulmonary Nodules
The study is designed as a multi-center prospective trial with two arms, ENB-EBUS-GS group and EBUS-GS group, and aimed to evaluate the diagnostic yield and operation time between the two groups.
- Trial name
- NCT03569306
- Testing
- ENB, EBUS-GS
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Chest Hospital
Endobronchial Ultrasound
EBUS Image Features in the Diagnosis of PPLs
The study is aimed to evaluate the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of endobronchial ultrasound (EBUS) image features in diagnosing peripheral pulmonary lesions…
- Trial name
- NCT03575715
- Testing
- EBUS
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Malignant Hydrothorax, NSCLC
A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC
A prospective study to evaluate consistency of different NGS-panel. Cell free DNA is purified from each malignant hydrothorax from NSCLC .Different NGS-panels are applied to perform in vitro diagnosis to detect Single Nucleotide…
- Trial name
- NCT03546452
- Testing
- in vitro NGS-panel
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Unresectable Stage III Non-small-cell Lung Cancer
Hypofractionated vs. Conventionally Fractionated Concurrent CRT for Unresectable Stage III NSCLC
This protocol is a phase III randomized controlled trial (RCT) evaluating the efficacy of hypofractionated vs. conventionally fractionated concurrent chemo-radiotherapy for unresectable stage III non-small-cell lung cancer
- Trial name
- HCFCCUSN (NCT03331575)
- Testing
- Arm1 (Hypofractionated radiotherapy)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
ENB Guided RFA for Early-stage Peripheral Lung Cancer
The objective of the study was to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy (ENB) guided radiofrequency ablation (RFA) for the treatment of early-stage peripheral lung cancer.
- Trial name
- NCT03009630
- Testing
- RFA, ENB
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital