Clinical trials: sponsored by St. Olavs Hospital
Cardiac Arrest
Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-traumatic Out of Hospital Cardiac Arrest
The primary aim of this trial is to assess the efficacy of resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct treatment to advanced cardiovascular life support (ACLS) in patients with out-of-hospital…
- Trial name
- REBOARREST (NCT04596514)
- Testing
- REBOA, usual procedure according to guidelines
- Where
- 11 sites in Denmark, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- St. Olavs Hospital
Chronic Subdural Hematoma
Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH)
This study is an open label randomized controlled trial. Patients with a symptomatic Chronic Subdural Hematoma (CSDH) confirmed on radiological imaging, planned for surgery, age over 18, free from other intracranial pathologies…
- Trial name
- RATATA (NCT07245264)
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- India
- Volunteers
- 274 people
- Sponsor
- St. Olavs Hospital
Episodic Migraine
Prophylactic Treatment With Atorvastatin for Episodic Migraine.
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- EStatinMig (NCT06248671)
- Testing
- Atorvastatin 40mg, Atorvastatin 20mg
- Where
- 6 sites in Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Bipolar Disorder
Investigation of Factors Associated With Preserved Cognitive Function in Bipolar Disorder
Bipolar disorder (BD) ïs the fourth leading cause of disability worldwide among young people. Differences in demographic and clinical characteristics between patients do not influence educational achievement and receipt of…
- Trial name
- NCT04454073
- Where
- Norway
- Volunteers
- 87 people
- Sponsor
- St. Olavs Hospital
High Grade Glioma
68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma
This interventional, clinical pilot-study will initiate and evaluate 68Ga/177Lu-PSMA theranostics in Norway as treatment alternative for patients with recurrent grade 3 and grade 4 gliomas.
- Trial name
- NCT05644080
- Testing
- 177Lu-PSMA I&T
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- St. Olavs Hospital
Breast Neoplasms, Cardiovascular Diseases
Acute and Long-term Cardiovascular Toxicity After Modern Radiotherapy for Breast Cancer
In Europe, breast cancer is by far the most common form of cancer diagnosed in women today, accounting for 29% of all cases. The 5-year survival rate is approximately 90%.
- Trial name
- NCT02541435
- Where
- 2 sites in Norway
- Volunteers
- 1,600 people
- Sponsor
- St. Olavs Hospital
Chronic Pain, Chronic Pain Syndrome
Collaboratory Treatment Pathway for Chronic Pain Patients.
In this multicenter randomized controlled trial, the aim is to evaluate the effectiveness of a standardized treatment pathway (STP) for patients referred to four participating pain clinics, by comparing it to treatment as usual…
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic (Non-malignant) Musculoskeletal Pain, Patients Referred to Multidisciplinary Pain Clinics
- Trial name
- PainPath (NCT07331766)
- Testing
- A collaborative treatment pathway for patients referred to multidisciplinary pain clinics in Norway, Treatment as usual
- Where
- 4 sites in Norway
- Volunteers
- 386 people
- Sponsor
- St. Olavs Hospital
Bariatric Surgery Candidate
Bariatric Surgery Observation Study Part 2
The goal of this observational study is to explore the longterm effects of two bariatric surgical procedures by inviting patients from three public hospitals who had Roux-en-Y gastric bypass or Sleeve gastrectomy to a follow-up…
- Trial name
- BAROBS2 (NCT05743166)
- Testing
- Bariatric surgery
- Where
- 3 sites in Norway
- Volunteers
- 687 people
- Sponsor
- St. Olavs Hospital
Post Traumatic Stress Disorder, Rape Sexual Assault
Early Psychological Intervention After Rape
Rape is a common cause of post-traumatic stress disorder (PTSD) among women, as around 30-50% will develop PTSD in the aftermath of rape.
- Conditions
- Post Traumatic Stress Disorder, Rape Sexual Assault, Sexual Dysfunctions, Psychological, Pelvic Floor Myalgia
- Trial name
- EIR (NCT05489133)
- Testing
- Modified prolonged exposure
- Where
- 4 sites in Norway
- Volunteers
- 166 people
- Sponsor
- St. Olavs Hospital
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Pneumothorax Iatrogenic Postprocedural, Air Embolism as A Complication of Medical Care
Complications After CT-guided Lung Biopsies at St. Olavs Hospital
At St. Olavs Hospital, a prospective collection of data on complications related to CT-guided lung biopsies has been conducted over several years as part of quality control study.
- Conditions
- Pneumothorax Iatrogenic Postprocedural, Air Embolism as A Complication of Medical Care, Hemoptysis
- Trial name
- KELSO (NCT07528170)
- Testing
- CT-guided needle biopsy of lung nodule
- Volunteers
- 1,200 people
- Sponsor
- St. Olavs Hospital
Multiple Sclerosis, Insomnia
A Digital Therapeutic to Improve Insomnia in Multiple Sclerosis: A Randomized Controlled Trial.
The goal of this randomized controlled trial is to test the effectiveness of digital cognitive behavioral therapy for insomnia (dCBT-I) compared with digital patient education about insomnia for people with Multiple Sclerosis…
- Trial name
- NorseMS (NCT06113666)
- Testing
- Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I), Digital patient education about insomnia (PE)
- Where
- Norway
- Volunteers
- 550 people
- Sponsor
- St. Olavs Hospital
Glioblastoma
Supramarginal Resection in Glioblastoma
Gliomas are the most common malignant brain tumor. Glioblastoma, WHO grade IV astrocytoma, is the most common subtype and unfortunately also the most aggressive subtype with median survival in population based cohorts being only…
- Trial name
- NCT04243005
- Testing
- Supramarginal resection, Conventional surgery
- Where
- 17 sites in Austria, Denmark and 4 more
- Volunteers
- 90 people
- Sponsor
- St. Olavs Hospital
Mental Disorder
Effect of Early Assessment Team for Patients Referred to Outpatient Mental Health Care
Loss of function and incapacity for work as a result of mental disorders are increasing, especially among young people (under 30 years of age), even though the prevalence of mental illness is fairly stable.
- Trial name
- NCT05087446
- Testing
- Early assessment team, Admission to General psychiatric outpatient clinic
- Where
- Norway
- Volunteers
- 588 people
- Sponsor
- St. Olavs Hospital
Depressive Episode
Chronotherapy for Depressive Episodes
Evidence-based treatments for depression, such as antidepressive medication, usually have a latency of 4 to 6 weeks before they achieve a therapeutic effect.
- Trial name
- NCT05691647
- Testing
- Chronotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- St. Olavs Hospital
Acquired Brain Injury, Executive Function Disorder
Goal Management Training (GMT) for Improvement of Cognitive Control Function After Acquired Brain Injury
The goal of this clinical trial is to investigate predictors of treatment outcome, and the effect of individual treatment components of Goal Management Training (GMT) for improvement of cognitive control function in people with…
- Trial name
- NCT06604000
- Testing
- GMT Usual, GMT Cuing, GMT Boost
- Where
- Norway
- Volunteers
- 116 people
- Sponsor
- St. Olavs Hospital
Testicular Neoplasms, Seminoma
Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer
One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors.
- Trial name
- SWENOTECA-ABC (NCT02341989)
- Testing
- Bleomycin Etoposide and Cisplatin, Carboplatin
- Where
- 2 sites in Norway
- Volunteers
- 348 people
- Sponsor
- St. Olavs Hospital
Breast Neoplasm Female
Piloting 18F-FAPI PET/MRI for Applications in Breast Cancer
Breast cancer is the most common type of cancer in Norwegian women, with 4,224 new cases in 2022. More precise diagnosis are expected to result in more accurate assessment of treatment effect, and to contribute to both providing…
- Trial name
- NCT07180433
- Testing
- FAPI PET/MR
- Volunteers
- 60 people
- Sponsor
- St. Olavs Hospital
Migraine
Candesartan for Migraine Prevention:
The main objective of this study is to see whether the favorable preventative effect of candesartan 16 mg per day in episodic migraine, that was found previously in two smaller randomized controlled cross-over studies, can be…
- Trial name
- CandMig-3 (NCT04574713)
- Testing
- Candesartan Oral Tablet 8 mg, Candesartan Oral Tablet 16 mg
- Where
- 10 sites in Estonia, Norway
- Volunteers
- 450 people
- Sponsor
- St. Olavs Hospital
Chronic Pain
Acceptance and Commitment Therapy With and Without Enhanced Mindfulness Training for Chronic Pain
As non-pharmacological alternatives, psychosocial treatments have been recommended for chronic pain management. One such treatment is Acceptance and Commitment Therapy (ACT).
- Trial name
- MUST (NCT04057144)
- Testing
- ACT, mindfulness exercises and audio recordings, Education program
- Where
- 4 sites in Norway
- Volunteers
- 667 people
- Sponsor
- St. Olavs Hospital